29 Questions
Which enzyme is responsible for the conversion of methotrexate to inhibit DNA synthesis?
Dihydrofolate reductase
What is the primary mode of action of Cyclosporine?
Inhibition of T-lymphocytes and T-helper cells
What is the purpose of the pH-dependent coating used in Asacol, Asacol HD, Delzicol, and Lialda?
To release the medication in response to intestinal pH
Which drug is a chimeric IgG1 monoclonal antibody that binds TNF-α?
Infliximab
What is a unique feature of Apriso's formulation that aids in its delayed and extended delivery to the colon?
Polymer matrix combined with enteric coating
What is the mechanism of action of Infliximab?
Induces T-cell apoptosis
Which medication is described as a dimer of two 5-ASA molecules, acting as a prodrug for mesalamine?
Olsalazine
Which enzyme does methotrexate inhibit in the metabolism of folic acid?
Dihydrofolate reductase
In the treatment of IBD, glucocorticoid enemas are primarily beneficial for patients with disease limited to which area?
Rectum and left colon
What is the main function of TNFα-inhibitors like Infliximab?
Suppress inflammation
What makes Budesonide (ENTOCORT ER) an effective treatment for ileocecal Crohn's disease?
Minimizes systemic side effects due to specific delivery and metabolism
What is the primary role of corticosteroids in the treatment of IBD?
Suppressing acute inflammation
What is a possible side effect of the biosimilar version of infliximab?
Yellow skin or eyes
Which symptom is not listed as a possible side effect of the new drug delivered subcutaneously?
Increased energy levels
What type of antibody is adalimumab in relation to TNF-α?
Fully humanized antibody
Which side effect involves difficulty in breathing?
Swelling in the face
What is a distinctive feature of Adalimumab compared to infliximab?
Contains murine sequences
Which symptom is not associated with the possible side effects of the biosimilar version of infliximab?
Increased appetite
What are some possible adverse effects of Natalizumab?
Red or painful skin
How does Etrasimod work in treating Ulcerative Colitis?
Binds to S1P-receptor to prevent lymphocytes from leaving lymphoid organs
What is the mechanism of action of Mirikizumab in treating Ulcerative Colitis?
Binds to the p19 subunit of IL-23
How is Etrasimod metabolized in the body?
Metabolized by CYP2C8, CYP3A4, CYP2C9
What percentage of radioactive doses of Etrasimod are identified in feces upon excretion?
82%
What is Certolizumab pegol designed to inhibit?
Both soluble and membrane-bound TNF-α
What receptor does Vedolizumab block in vitro?
a4b7 integrin
Which organ system does Vedolizumab affect by blocking lymphocyte entry?
Digestive system
What is a possible adverse effect of Vedolizumab related to vision?
Blurred vision
Which biologic agent targets the cellular adhesion molecule α4-integrin?
Natalizumab
What risk is associated with the use of Natalizumab as an immunomodulator?
Development of PML
Test your knowledge on the biosimilar version of infliximab delivered subcutaneously, considered a new drug due to its delivery method. Explore possible side effects such as allergic reactions, changes in urination, gastrointestinal symptoms, and fever.
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