Podcast
Questions and Answers
Which enzyme is responsible for the conversion of methotrexate to inhibit DNA synthesis?
Which enzyme is responsible for the conversion of methotrexate to inhibit DNA synthesis?
- Dihydrofolate reductase (correct)
- Hypoxanthine–guanine phosphoribosyl transferase (HGPRT)
- Xanthine oxidase
- Thiopurine methyltransferase (TPMT)
What is the primary mode of action of Cyclosporine?
What is the primary mode of action of Cyclosporine?
- Inhibition of folic acid reductase
- Inhibition of purine nucleotide synthesis
- Inhibition of T-lymphocytes and T-helper cells (correct)
- Activation of TNFα
What is the purpose of the pH-dependent coating used in Asacol, Asacol HD, Delzicol, and Lialda?
What is the purpose of the pH-dependent coating used in Asacol, Asacol HD, Delzicol, and Lialda?
- To enhance the absorption of the medication
- To release the medication in response to stomach pH
- To release the medication in response to intestinal pH (correct)
- To prevent the medication from releasing in the stomach
Which drug is a chimeric IgG1 monoclonal antibody that binds TNF-α?
Which drug is a chimeric IgG1 monoclonal antibody that binds TNF-α?
What is a unique feature of Apriso's formulation that aids in its delayed and extended delivery to the colon?
What is a unique feature of Apriso's formulation that aids in its delayed and extended delivery to the colon?
What is the mechanism of action of Infliximab?
What is the mechanism of action of Infliximab?
Which medication is described as a dimer of two 5-ASA molecules, acting as a prodrug for mesalamine?
Which medication is described as a dimer of two 5-ASA molecules, acting as a prodrug for mesalamine?
Which enzyme does methotrexate inhibit in the metabolism of folic acid?
Which enzyme does methotrexate inhibit in the metabolism of folic acid?
In the treatment of IBD, glucocorticoid enemas are primarily beneficial for patients with disease limited to which area?
In the treatment of IBD, glucocorticoid enemas are primarily beneficial for patients with disease limited to which area?
What is the main function of TNFα-inhibitors like Infliximab?
What is the main function of TNFα-inhibitors like Infliximab?
What makes Budesonide (ENTOCORT ER) an effective treatment for ileocecal Crohn's disease?
What makes Budesonide (ENTOCORT ER) an effective treatment for ileocecal Crohn's disease?
What is the primary role of corticosteroids in the treatment of IBD?
What is the primary role of corticosteroids in the treatment of IBD?
What is a possible side effect of the biosimilar version of infliximab?
What is a possible side effect of the biosimilar version of infliximab?
Which symptom is not listed as a possible side effect of the new drug delivered subcutaneously?
Which symptom is not listed as a possible side effect of the new drug delivered subcutaneously?
What type of antibody is adalimumab in relation to TNF-α?
What type of antibody is adalimumab in relation to TNF-α?
Which side effect involves difficulty in breathing?
Which side effect involves difficulty in breathing?
What is a distinctive feature of Adalimumab compared to infliximab?
What is a distinctive feature of Adalimumab compared to infliximab?
Which symptom is not associated with the possible side effects of the biosimilar version of infliximab?
Which symptom is not associated with the possible side effects of the biosimilar version of infliximab?
What are some possible adverse effects of Natalizumab?
What are some possible adverse effects of Natalizumab?
How does Etrasimod work in treating Ulcerative Colitis?
How does Etrasimod work in treating Ulcerative Colitis?
What is the mechanism of action of Mirikizumab in treating Ulcerative Colitis?
What is the mechanism of action of Mirikizumab in treating Ulcerative Colitis?
How is Etrasimod metabolized in the body?
How is Etrasimod metabolized in the body?
What percentage of radioactive doses of Etrasimod are identified in feces upon excretion?
What percentage of radioactive doses of Etrasimod are identified in feces upon excretion?
What is Certolizumab pegol designed to inhibit?
What is Certolizumab pegol designed to inhibit?
What receptor does Vedolizumab block in vitro?
What receptor does Vedolizumab block in vitro?
Which organ system does Vedolizumab affect by blocking lymphocyte entry?
Which organ system does Vedolizumab affect by blocking lymphocyte entry?
What is a possible adverse effect of Vedolizumab related to vision?
What is a possible adverse effect of Vedolizumab related to vision?
Which biologic agent targets the cellular adhesion molecule α4-integrin?
Which biologic agent targets the cellular adhesion molecule α4-integrin?
What risk is associated with the use of Natalizumab as an immunomodulator?
What risk is associated with the use of Natalizumab as an immunomodulator?
