Biosimilar Infliximab Subcutaneous Delivery Quiz

Play an AI-generated podcast conversation about this lesson

Which enzyme is responsible for the conversion of methotrexate to inhibit DNA synthesis?

Dihydrofolate reductase (correct)

Hypoxanthine–guanine phosphoribosyl transferase (HGPRT)

Xanthine oxidase

Thiopurine methyltransferase (TPMT)

What is the primary mode of action of Cyclosporine?

Inhibition of folic acid reductase

Inhibition of purine nucleotide synthesis

Inhibition of T-lymphocytes and T-helper cells (correct)

Activation of TNFα

What is the purpose of the pH-dependent coating used in Asacol, Asacol HD, Delzicol, and Lialda?

To enhance the absorption of the medication

To release the medication in response to stomach pH

To release the medication in response to intestinal pH (correct)

To prevent the medication from releasing in the stomach

Which drug is a chimeric IgG1 monoclonal antibody that binds TNF-α?

Infliximab Signup and view all the answers

What is a unique feature of Apriso's formulation that aids in its delayed and extended delivery to the colon?

Polymer matrix combined with enteric coating Signup and view all the answers

What is the mechanism of action of Infliximab?

Induces T-cell apoptosis Signup and view all the answers

Which medication is described as a dimer of two 5-ASA molecules, acting as a prodrug for mesalamine?

Olsalazine Signup and view all the answers

Which enzyme does methotrexate inhibit in the metabolism of folic acid?

Dihydrofolate reductase Signup and view all the answers

In the treatment of IBD, glucocorticoid enemas are primarily beneficial for patients with disease limited to which area?

Rectum and left colon Signup and view all the answers

What is the main function of TNFα-inhibitors like Infliximab?

Suppress inflammation Signup and view all the answers

What makes Budesonide (ENTOCORT ER) an effective treatment for ileocecal Crohn's disease?

Minimizes systemic side effects due to specific delivery and metabolism Signup and view all the answers

What is the primary role of corticosteroids in the treatment of IBD?

Suppressing acute inflammation Signup and view all the answers

What is a possible side effect of the biosimilar version of infliximab?

Yellow skin or eyes Signup and view all the answers

Which symptom is not listed as a possible side effect of the new drug delivered subcutaneously?

Increased energy levels Signup and view all the answers

What type of antibody is adalimumab in relation to TNF-α?

Fully humanized antibody Signup and view all the answers

Which side effect involves difficulty in breathing?

Swelling in the face Signup and view all the answers

What is a distinctive feature of Adalimumab compared to infliximab?

Contains murine sequences Signup and view all the answers

Which symptom is not associated with the possible side effects of the biosimilar version of infliximab?

Increased appetite Signup and view all the answers

What are some possible adverse effects of Natalizumab?

Red or painful skin Signup and view all the answers

How does Etrasimod work in treating Ulcerative Colitis?

Binds to S1P-receptor to prevent lymphocytes from leaving lymphoid organs Signup and view all the answers

What is the mechanism of action of Mirikizumab in treating Ulcerative Colitis?

Binds to the p19 subunit of IL-23 Signup and view all the answers

How is Etrasimod metabolized in the body?

Metabolized by CYP2C8, CYP3A4, CYP2C9 Signup and view all the answers

What percentage of radioactive doses of Etrasimod are identified in feces upon excretion?

82% Signup and view all the answers

What is Certolizumab pegol designed to inhibit?

Both soluble and membrane-bound TNF-α Signup and view all the answers

What receptor does Vedolizumab block in vitro?

a4b7 integrin Signup and view all the answers

Which organ system does Vedolizumab affect by blocking lymphocyte entry?

Digestive system Signup and view all the answers

What is a possible adverse effect of Vedolizumab related to vision?

Blurred vision Signup and view all the answers

Which biologic agent targets the cellular adhesion molecule α4-integrin?

Natalizumab Signup and view all the answers

What risk is associated with the use of Natalizumab as an immunomodulator?

Development of PML Signup and view all the answers