Stomach Acid Secretion Quiz
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Questions and Answers

What is the primary function of the K+/H+ exchanger in parietal cells?

  • To secrete K+ ions into the stomach lumen
  • To exchange HCO3- for Cl- ions
  • To secrete H+ ions into the stomach lumen
  • To regulate the pH of the parietal cell cytoplasm (correct)

What is the primary function of the HCO3-/Cl- exchanger in parietal cells?

  • To secrete Cl- ions into the stomach lumen
  • To regulate the pH of the parietal cell cytoplasm
  • To exchange K+ for H+ ions
  • To secrete HCO3- ions into the stomach lumen (correct)

How does somatostatin inhibit acid secretion by parietal cells?

  • By reducing cAMP concentrations in parietal cells (correct)
  • By directly blocking the proton pump in parietal cells
  • By increasing cAMP concentrations in parietal cells
  • By stimulating the release of histamine from ECL cells

What is the primary cause of the 'alkaline tide' phenomenon?

<p>The absorption of HCO3- from the stomach lumen into the bloodstream (B)</p> Signup and view all the answers

Which of the following is the most potent regulator of parietal cell acid secretion?

<p>Histamine (from ECL cells) (C)</p> Signup and view all the answers

What is the primary mechanism by which drugs like omeprazole inhibit acid secretion by parietal cells?

<p>By inhibiting the proton pump (H+/K+ ATPase) (A)</p> Signup and view all the answers

What is the primary cation associated with pancreatic secretions during active eating?

<p>Na+ (D)</p> Signup and view all the answers

In the pancreas during stimulation of secretion, what is the relationship between anions and cations?

<p>Anions equal cations (A)</p> Signup and view all the answers

How is HCO3- transported into the lumen of the pancreatic duct?

<p>By an HCO3-/Cl- exchanger (B)</p> Signup and view all the answers

What is the effect of cystic fibrosis on pancreatic duct cells?

<p>Prevents release of HCO3 (C)</p> Signup and view all the answers

What happens to the pancreatic juice's osmolality with increased flow rate?

<p>Remains constant (C)</p> Signup and view all the answers

How is the byproduct H+ transported out of the duct cell?

<p>By a Na/H exchanger (C)</p> Signup and view all the answers

What is the primary role of the K/H+ exchanger in parietal cells?

<p>To transport K+ into the cell and H+ out of the cell into the stomach lumen (B)</p> Signup and view all the answers

What is the function of the HCO3-/Cl- exchanger in parietal cells?

<p>To transport HCO3- out of the cell and Cl- into the cell (C)</p> Signup and view all the answers

What is the primary function of somatostatin in regulating gastric acid secretion?

<p>Inhibits parietal cells from secreting HCl (D)</p> Signup and view all the answers

What is the 'alkaline tide' in the context of gastric acid secretion?

<p>The increased blood pH due to the release of HCO3- from parietal cells (B)</p> Signup and view all the answers

Which of the following is true regarding the regulation of HCl secretion by parietal cells?

<p>HCl secretion requires a high metabolic rate and ATP production in parietal cells (C)</p> Signup and view all the answers

What is the primary source of H+ ions for HCl secretion by parietal cells?

<p>Conversion of CO2 and H2O into H2CO3 and subsequently into H+ and HCO3- (B)</p> Signup and view all the answers

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