Stomach Acid Secretion Quiz

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What is the primary function of the K+/H+ exchanger in parietal cells?

To secrete K+ ions into the stomach lumen

To exchange HCO3- for Cl- ions

To secrete H+ ions into the stomach lumen

To regulate the pH of the parietal cell cytoplasm (correct)

What is the primary function of the HCO3-/Cl- exchanger in parietal cells?

To secrete Cl- ions into the stomach lumen

To regulate the pH of the parietal cell cytoplasm

To exchange K+ for H+ ions

To secrete HCO3- ions into the stomach lumen (correct)

How does somatostatin inhibit acid secretion by parietal cells?

By reducing cAMP concentrations in parietal cells (correct)

By directly blocking the proton pump in parietal cells

By increasing cAMP concentrations in parietal cells

By stimulating the release of histamine from ECL cells

What is the primary cause of the 'alkaline tide' phenomenon?

The absorption of HCO3- from the stomach lumen into the bloodstream Signup and view all the answers

Which of the following is the most potent regulator of parietal cell acid secretion?

Histamine (from ECL cells) Signup and view all the answers

What is the primary mechanism by which drugs like omeprazole inhibit acid secretion by parietal cells?

By inhibiting the proton pump (H+/K+ ATPase) Signup and view all the answers

What is the primary cation associated with pancreatic secretions during active eating?

Na+ Signup and view all the answers

In the pancreas during stimulation of secretion, what is the relationship between anions and cations?

Anions equal cations Signup and view all the answers

How is HCO3- transported into the lumen of the pancreatic duct?

By an HCO3-/Cl- exchanger Signup and view all the answers

What is the effect of cystic fibrosis on pancreatic duct cells?

Prevents release of HCO3 Signup and view all the answers

What happens to the pancreatic juice's osmolality with increased flow rate?

Remains constant Signup and view all the answers

How is the byproduct H+ transported out of the duct cell?

By a Na/H exchanger Signup and view all the answers

What is the primary role of the K/H+ exchanger in parietal cells?

To transport K+ into the cell and H+ out of the cell into the stomach lumen Signup and view all the answers

What is the function of the HCO3-/Cl- exchanger in parietal cells?

To transport HCO3- out of the cell and Cl- into the cell Signup and view all the answers

What is the primary function of somatostatin in regulating gastric acid secretion?

Inhibits parietal cells from secreting HCl Signup and view all the answers

What is the 'alkaline tide' in the context of gastric acid secretion?

The increased blood pH due to the release of HCO3- from parietal cells Signup and view all the answers

Which of the following is true regarding the regulation of HCl secretion by parietal cells?

HCl secretion requires a high metabolic rate and ATP production in parietal cells Signup and view all the answers

What is the primary source of H+ ions for HCl secretion by parietal cells?

Conversion of CO2 and H2O into H2CO3 and subsequently into H+ and HCO3- Signup and view all the answers