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Questions and Answers
What is the primary characteristic of stiff-person syndrome (SPS)?
What is the primary characteristic of stiff-person syndrome (SPS)?
- Tremors and shaking
- Weakness in the limbs
- Numbness and tingling sensation
- Progressive muscular rigidity and stiffness (correct)
What is the approximate prevalence of SPS in the population?
What is the approximate prevalence of SPS in the population?
- 1 in 10,000 people
- 1 in 500,000 people
- 1 in a million people (correct)
- 1 in 100,000 people
Which antibodies are generally found in SPS patients?
Which antibodies are generally found in SPS patients?
- Thyroid peroxidase antibodies
- Insulin antibodies
- Glutamic acid decarboxylase (GAD) antibodies (correct)
- Antinuclear antibodies
What is the most common treatment for symptom relief from stiffness in SPS?
What is the most common treatment for symptom relief from stiffness in SPS?
When was SPS first described?
When was SPS first described?
What is the most common symptom of stiff-person syndrome (SPS)?
What is the most common symptom of stiff-person syndrome (SPS)?
What is the approximate prevalence of SPS in the population?
What is the approximate prevalence of SPS in the population?
When was SPS first described?
When was SPS first described?
Which antibodies are generally found in SPS patients?
Which antibodies are generally found in SPS patients?
What is the most common treatment for symptom relief from stiffness in SPS?
What is the most common treatment for symptom relief from stiffness in SPS?
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Study Notes
Stiff-Person Syndrome (SPS) Characteristics
- The primary characteristic of SPS is progressive stiffness and rigidity of the muscles.
Prevalence of SPS
- The approximate prevalence of SPS in the population is 1 in 1 million people.
Antibodies in SPS Patients
- SPS patients generally have antibodies against glutamic acid decarboxylase (GAD) and/or amphiphysin.
Treatment for SPS
- The most common treatment for symptom relief from stiffness in SPS is medication, typically benzodiazepines, baclofen, or diazepam.
History of SPS
- SPS was first described in 1956 by Moersch and Woltman.
Symptoms of SPS
- The most common symptom of SPS is progressive stiffness and rigidity of the muscles, often accompanied by painful muscle spasms.
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