10 Questions
What is the primary characteristic of stiff-person syndrome (SPS)?
Progressive muscular rigidity and stiffness
What is the approximate prevalence of SPS in the population?
1 in a million people
Which antibodies are generally found in SPS patients?
Glutamic acid decarboxylase (GAD) antibodies
What is the most common treatment for symptom relief from stiffness in SPS?
Benzodiazepine-class drugs
When was SPS first described?
1956
What is the most common symptom of stiff-person syndrome (SPS)?
Progressive muscular rigidity and stiffness
What is the approximate prevalence of SPS in the population?
1 in a million people
When was SPS first described?
1956
Which antibodies are generally found in SPS patients?
Glutamic acid decarboxylase (GAD) antibodies
What is the most common treatment for symptom relief from stiffness in SPS?
Benzodiazepine-class drugs
Study Notes
Stiff-Person Syndrome (SPS) Characteristics
- The primary characteristic of SPS is progressive stiffness and rigidity of the muscles.
Prevalence of SPS
- The approximate prevalence of SPS in the population is 1 in 1 million people.
Antibodies in SPS Patients
- SPS patients generally have antibodies against glutamic acid decarboxylase (GAD) and/or amphiphysin.
Treatment for SPS
- The most common treatment for symptom relief from stiffness in SPS is medication, typically benzodiazepines, baclofen, or diazepam.
History of SPS
- SPS was first described in 1956 by Moersch and Woltman.
Symptoms of SPS
- The most common symptom of SPS is progressive stiffness and rigidity of the muscles, often accompanied by painful muscle spasms.
Test your knowledge about the rare neurologic disorder known as Stiff-person syndrome (SPS), characterized by progressive muscular rigidity and stiffness, primarily affecting the truncal muscles and resulting in postural deformities. Learn about its symptoms, prevalence, and demographics.
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