Sect 9 Quiz Mixed Hard

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Questions and Answers

Which of the following best describes stem cells?

  • Specialized cells that cannot divide
  • Cells that only exist in embryos
  • Undifferentiated cells capable of self-renewal and differentiation (correct)
  • Cells that have no defined function

Apoptosis is a form of programmed cell death that occurs when a cell is damaged.

True (A)

What is meant by 'cell lineage'?

The developmental history of a cell from its birth until its final differentiation into a specialized cell type.

Which type of stem cells have the highest potential for differentiation?

<p>Embryonic stem cells (B)</p> Signup and view all the answers

The process of a cell dividing into two identical cells is known as __________ cell division.

<p>symmetric</p> Signup and view all the answers

Fetal stem cells are less powerful than adult stem cells.

<p>False (B)</p> Signup and view all the answers

Which of the following cell types is NOT a category of stem cells?

<p>Mortipotent cells (A)</p> Signup and view all the answers

What stage do human embryos reach where each cell can form every tissue?

<p>8-cell stage</p> Signup and view all the answers

Match the terms to their correct definitions:

<p>Apoptosome = A protein complex responsible for activating caspases Caspases = Enzymes that execute the cell death program Embryonic stem cells = Cells that can become any cell type in the body Bcl-2 family = Proteins that regulate apoptosis</p> Signup and view all the answers

Embryonic stem cells are derived from the __________ of an early-stage embryo.

<p>blastocyst</p> Signup and view all the answers

Multipotent stem cells can differentiate into any cell type in the body.

<p>False (B)</p> Signup and view all the answers

Match the following types of stem cells with their characteristics:

<p>Fetal stem cells = More powerful than adult stem cells Embryonic stem cells = Most potential for differentiation Adult stem cells = Multipotent and involved in cell replacement Induced stem cells = Reprogrammed adult cells</p> Signup and view all the answers

What is a key characteristic of iPS cells?

<p>Induced pluripotent stem cells can be generated from adult cells and can differentiate into any cell type.</p> Signup and view all the answers

What term describes stem cells that can give rise to all embryonic tissues but not extraembryonic tissues?

<p>Pluripotent (A)</p> Signup and view all the answers

Adult stem cells can be grown indefinitely in culture.

<p>False (B)</p> Signup and view all the answers

Which transcription factors are crucial for maintaining the pluripotency of embryonic stem cells?

<p>Oct4, Sox2, and Nanog</p> Signup and view all the answers

What is the primary characteristic of multipotent cells?

<p>They can develop into multiple, but not all, cell types. (C)</p> Signup and view all the answers

Intestinal stem cells proliferate and generate all types of epithelial cells within the intestine.

<p>True (A)</p> Signup and view all the answers

Where are stem cells located in the intestinal epithelium?

<p>Deep in the intestinal wall in pits called crypts.</p> Signup and view all the answers

Hematopoietic stem cells replenish all necessary _____ cells.

<p>blood</p> Signup and view all the answers

Match the following terms with their descriptions:

<p>Multipotent cells = Can develop into multiple cell types Pluripotent cells = Can develop into any cell type Transiently amplifying cells = Rapidly divide and produce restricted progenitor cells Niche = Specialized environment that supports stem cells</p> Signup and view all the answers

What significantly controls the proliferation and differentiation of stem cells in niches?

<p>Signaling pathways (D)</p> Signup and view all the answers

Intestinal epithelial cells are only regenerated when damaged.

<p>False (B)</p> Signup and view all the answers

What is the turnover rate of intestinal epithelium cells in humans?

<p>Every 5 days</p> Signup and view all the answers

What is the primary role of enterocytes when the Notch signal is present?

<p>To differentiate into absorptive enterocytes (D)</p> Signup and view all the answers

Paneth cells are produced every 3-6 weeks from Lgr5+ cells.

<p>False (B)</p> Signup and view all the answers

What distinguishes tuft cells from other intestinal cells?

<p>They are chemosensory cells.</p> Signup and view all the answers

The main function of goblet cells is to secrete ________.

<p>mucus</p> Signup and view all the answers

Which factor is NOT involved in deriving induced pluripotent stem (iPS) cells?

<p>MHC (C)</p> Signup and view all the answers

Match the following cell types with their functions:

<p>Goblet cells = Secrete mucus M cells = Take up intestinal antigens Paneth cells = Secrete antimicrobial proteins iPS cells = Can differentiate into various cell types</p> Signup and view all the answers

What type of cell division do many yeasts and fungi undergo?

<p>Symmetric cell division</p> Signup and view all the answers

Telocytes are the primary source of growth factors necessary for stem cell self-renewal.

<p>True (A)</p> Signup and view all the answers

What is a requirement for asymmetric cell division to occur?

<p>The parental cell must become polarized before division. (B)</p> Signup and view all the answers

All daughter cells produced by asymmetric cell division are identical in size and shape.

<p>False (B)</p> Signup and view all the answers

What are the three components of the conserved apoptotic pathways in vertebrate cells?

<p>Membrane-bound regulatory proteins, cytosolic regulatory proteins, apoptotic proteases.</p> Signup and view all the answers

Without trophic factors, vertebrate cells undergo __________.

<p>apoptosis</p> Signup and view all the answers

Match the following terms with their descriptions:

<p>Caspases = Apoptotic proteases in vertebrates Cell polarity determinants = Asymmetrically localized mRNAs, proteins, and lipids Signal transduction pathway = Initiates the regulation of the cytoskeleton Apoptosis = Programmed cell death</p> Signup and view all the answers

What is the first step in generating polarized cells?

<p>Exposing cells to a spatial clue. (B)</p> Signup and view all the answers

The mitotic spindle's position can affect the fate of the daughter cells.

<p>True (A)</p> Signup and view all the answers

Asymmetric cell division involves the unequal distribution of cell contents, such as __________ and proteins.

<p>mRNA</p> Signup and view all the answers

What is the primary function of caspases once activated?

<p>Cleavage of specific intracellular substrates (A)</p> Signup and view all the answers

Caspase activation can occur without the binding of CED-4 and Apaf-1.

<p>False (B)</p> Signup and view all the answers

What happens to apoptotic cells during the process of apoptosis?

<p>They shrink, condense, and fragment into membrane-bound apoptotic bodies.</p> Signup and view all the answers

Bcl-2 family proteins include both pro- and anti-______ proteins.

<p>apoptotic</p> Signup and view all the answers

Which proteins promote caspase activation and cell death by escaping into the cytosol?

<p>Cytochrome c and SMAC/DIABLO (C)</p> Signup and view all the answers

The Bcl-2 protein facilitates apoptosis by preventing the oligomerization of Bax and Bak.

<p>False (B)</p> Signup and view all the answers

What triggers the oligomerization of Bax and Bak proteins?

<p>Environmental stress or activation of BH3-only proteins.</p> Signup and view all the answers

Match each protein to its role in apoptosis:

<p>Bax = Pro-apoptotic protein that forms channels in the mitochondrial membrane Bcl-2 = Anti-apoptotic protein that inhibits Bax and Bak Puma = BH3-only protein that promotes apoptosis 14-3-3 protein = Sequesters phosphorylated Bad</p> Signup and view all the answers

Flashcards

Stem Cell

An unspecialized cell capable of self-renewal and producing specialized cells.

Cell Lineage

The developmental history of a cell, from birth to differentiation into a specialized cell type.

Cell Fate

The ultimate cell type a specific cell will develop into.

Apoptosis

Programmed cell death, essential for development and homeostasis.

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Embryonic Stem Cells

Stem cells derived from embryos, known for their pluripotency.

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iPS Cells

Induced Pluripotent Stem Cells, adult cells reprogrammed to become pluripotent.

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Pluripotent

Stem cells capable of differentiating into various cell types, but not all.

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Multipotent

Stem cells capable of differentiating into several related cell types.

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Totipotent

Stem cells capable of differentiating into any cell type, including extra-embryonic tissues.

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Progenitor Cells

Cells that are partially specialized and committed to a particular lineage of cells.

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Fetal stem cells

Stem cells obtained from fetuses, possessing greater differentiation potential than adult stem cells.

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Embryonic stem cells

Stem cells sourced from the inner cell mass of a blastocyst, an early-stage embryo.

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Induced pluripotent stem cells (iPS)

Adult cells reprogrammed to have stem cell capabilities.

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Totipotent cells

Cells capable of developing into any cell type in the embryo and extraembryonic tissues (e.g., placenta).

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Pluripotent cells

Cells able to differentiate into all the cell types of the embryo, excluding extraembryonic tissues.

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Multipotent cells

Stem cells differentiating into several cell types within a certain tissue or organ system.

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Unipotent cells

Cells with the ability to become only one particular cell type.

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Inner Cell Mass

Specialized region of cells found within the early embryo, giving rise to all embryonic tissues, but not extraembryonic tissues.

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Adult stem cells

Stem cells found in adult tissues that support the regeneration of those tissues.

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Blastocyst

An early stage of the developing embryo that typically occurs 4-5 days after fertilization, containing an inner cell mass.

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Multipotent stem cells

Stem cells that can differentiate into multiple cell types, but are limited compared to pluripotent cells.

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Stem cell population constancy

The number of stem cells of a specific type remains the same or increases throughout an organism's lifetime.

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Transiently amplifying cells

Daughter cells that divide rapidly and undergo limited self-renewal divisions, ultimately producing lineage-restricted progenitor cells.

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Hematopoietic stem cells

Stem cells that replenish all types of blood cells.

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Progenitor cells and precursors

Cells that proliferate under the control of specific proteins (cytokines) to produce different cell types.

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Intestinal stem cells

Stem cells that continuously generate all cells of the intestinal lining (epithelium).

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Intestinal epithelium

The tissue lining the intestine, which is highly regenerative.

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Intestinal stem cell niche

The environment that helps intestinal stem cells maintain self-renewal and prevents premature differentiation.

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Lgr5 receptor

A receptor expressed by intestinal stem cells at the base of crypts.

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Wnt pathway

A signaling pathway that plays a crucial role in maintaining intestinal stem cells in an undifferentiated state.

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Crypts

Pits located deep in the intestinal wall where intestinal stem cells reside.

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Absorptive enterocytes

The most abundant cells in the intestinal epithelium, transporting nutrients for survival.

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Asymmetric Cell Division

A cell division process where daughter cells inherit different components (like mRNA, proteins), resulting in variations in their size, shape, or protein content, even though they share the same genes.

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Caspase activation

Caspases are enzymes that trigger cell death. Other proteins help activate them.

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Cell Polarity

The process where a cell establishes an internal directional pattern, crucial for distributing cell components asymmetrically during division.

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Apoptotic bodies

Small membrane-bound packages of cell fragments released during apoptosis, engulfed by other cells.

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Necrosis vs. Apoptosis

Necrosis is uncontrolled cell death (bursting and damaging surrounding cells). Apoptosis is controlled cell death (cell shrinks and fragments).

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Cell Polarity Determinants

Specific mRNA, proteins, and lipids that are distributed unevenly in a cell to create polarity and influence future cell fate.

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Mitotic Spindle Orientation

The alignment of the mitotic spindle during cell division; it dictates the segregation of cell polarity determinants to daughter cells.

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Bcl-2 family

A group of proteins (some pro-survival, some pro-death) that regulate apoptosis.

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Trophic Factors

Essential signals (molecules) that support cell survival, and whose absence leads to programmed cell death (apoptosis).

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Bax/Bak oligomerization

Bax and Bak proteins form channels to release cytochrome c from mitochondria, triggering caspase activation.

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Apoptosis (Programmed Cell Death)

A controlled process of cell suicide essential for development, tissue maintenance, and homeostasis caused by the lack of signals.

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Cytochrome c release

Cytochrome c escapes mitochondria during apoptosis, activating caspase cascade.

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Pro-apoptotic BH3-only proteins

Proteins like Puma, Bad, and Bim that bind to anti-apoptotic Bcl-2 proteins, promoting cell death.

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Caspases

Regulatory proteins (enzymes) that carry out the process of apoptosis in vertebrates.

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Symmetric Cell Division

Daughter cells inherit virtually identical sets of molecules and components from the parental cell. A common process in mature hepatocytes.

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Trophic factors

Substances that induce cell survival by regulating interactions within the apoptotic cell pathway.

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Spatial Clue

An external signal or cue that instructs a cell on which direction to establish its polarity.

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DNA damage

Cellular damage that can induce the synthesis of Puma proteins, which trigger apoptosis.

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Notch signaling pathway

A pathway that helps determine whether Lgr5+ cells become absorptive or secretory cells in the intestines.

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Lgr5+ cells

A type of stem cell that plays a role in intestinal cell differentiation.

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Paneth cells

Cells in the intestine that produce antimicrobial proteins.

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Transit amplifying cells

Cells that produce Paneth cells, with a turnover every 3-6 weeks.

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Reserve stem cells (+4)

Stem cells that can restore Lgr5+ stem cells after injury.

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Telocytes

Cells with long protrusions that provide growth factors for stem cells in the intestines.

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Enteroendocrine cells

Specialized cells that produce and release hormones in the intestines.

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Tuft cells

Chemosensory cells in the lining of intestines and respiratory tract.

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Goblet cells

Cells that secrete mucus to protect the intestinal lining.

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M cells

Specialized immune cells that absorb intestinal antigens.

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iPS cells

Induced pluripotent stem cells, derived from somatic cells.

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Symmetric cell division

Cell division that creates two identical daughter cells.

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Study Notes

Stem Cells, Cell Asymmetry, and Cell Death

  • Learning Objectives: Define apoptosis, apoptosome, asymmetric/symmetric cell division, Bcl-2 family, caspases, cell fate, cell lineage, embryonic stem cells, iPS cells, multipotent, pluripotent, progenitor cells, stem cell, stem-cell niche survival signals, and totipotent. Differentiate stem cell categories. Discuss key stem cells in the intestinal stem cell niche. Compare apoptosis and necrosis.

  • Cell Lineage: Developmental history of a cell from birth to final division and differentiation is its cell fate. Cell lineage traces the birth order of cells as they progressively become more specific in development. Examples include the nematode worm C. elegans.

  • Stem Cells: Unspecialized cells capable of self-renewal and generating specialized cells. Four main types: adult stem cells (derived from adult tissues), fetal stem cells (from fetuses), embryonic stem cells (from blastocysts), and induced pluripotent stem cells (iPS) (adult cells reprogrammed).

  • Totipotent Cells: Human embryos at the 8-cell stage, each still capable of forming all embryonic and extraembryonic tissues (e.g., placental).

  • ES Cells: At the blastocyst stage, a distinctive inner cell mass can form embryonic stem cells (ES cells) that have the potential to generate all embryonic tissues, but not extraembryonic tissues. ES cells are pluripotent.

  • Pluripotency of ES Cells: Controlled by factors like DNA methylation, chromatin regulators, microRNAs, and transcription factors (Oct4, Sox2, Nanog).

  • Adult Stem Cells: Multipotent, capable of differentiating into various cell types within a specific tissue, but less versatile than ES cells. Important for tissue maintenance and repair.

  • Polarized Cells: Cells that develop a distinct orientation. Cells use receptors to sense cues, initiate signal transduction pathways, and reorganize their cytoskeleton.

  • Cell Polarity Determinants: MRNAs, proteins, and lipids organized in a non-uniform, localized way within the cell. This organization leads to different fate determinants in daughter cells during the cell division.

  • Cell Death (Apoptosis): Programmed cell death in vertebrates, with three components: membrane-bound regulatory proteins, cytosolic regulatory proteins, and apoptotic proteases (caspases).

  • Apoptotic Pathways: Activated caspases cleave specific intracellular substrates leading to cell demise. Other proteins (CED-4 and Apaf-1) are essential for caspase activation. Apoptotic cells shrink, condense, and fragment. They are engulfed, versus necrotic cells.

  • Bcl-2 Family Proteins: Transmembrane proteins containing pro- and anti-apoptotic members. Pro-apoptotic Bcl-2 family members (Bax and Bak) form channels in the mitochondrial membrane leading to cell death, while anti-apoptotic members (Bcl-2, Bcl-XL) prevent oligomerization of Bax/Bak and cell death.

  • Fas-mediated Apoptosis: Binding of extracellular death signals (e.g., TNFα and Fas Ligand) to their respective receptors triggers the caspase cascade.

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