Stem Cell Niche Factors Quiz

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What is the role of GFAP in the context of stem cells near sinusoidal niches?

Encourages megakaryocytes to influence HSCs

Promotes self-renewal and differentiation of HSCs (correct)

Induces feedback from macrophages to the niche

Inhibits HSC migration and proliferation

Which of the following is NOT mentioned as a mechanism to protect adult stem cells and prevent premature aging?

ABC transporters

Telomerase activity

DNA repair machinery

High activity of the enzyme catalase (correct)

What is a characteristic of stem cells regarding toxic substances?

Lack of DNA repair machinery to counteract toxic substances

Inability to efflux toxic substances

Low levels of telomerase activity to tolerate toxic substances

High activity of ABC transporters to efflux toxic substances (correct)

Where are less quiescent or activated HSCs primarily located in relation to sinusoidal niches?

Near the niches Signup and view all the answers

What is an example of HSC-derived progeny that can influence HSC migration or proliferation?

Erythropoietin (EPO) Signup and view all the answers

What is a protective mechanism for stem cells against premature aging due to the absence of DNA repair machinery?

Telomerase activity Signup and view all the answers

Where do adult stem cells in the intestine reside?

Base of the crypt Signup and view all the answers

What are the factors that can influence stem cell fate in their niche?

Soluble factors, physicochemical factors, and cell-cell interactions Signup and view all the answers

Which cells are responsible for maintaining dormant hematopoietic stem cells (HSCs) in the bone marrow?

Perivascular and endothelial cells Signup and view all the answers

What is a key structure for the maintenance of adult hematopoietic stem cells (HSCs) in the bone marrow?

Arterioles Signup and view all the answers

Which signaling pathways are involved in lineage commitment of adult stem cells in the intestine?

Wnt and Notch signaling Signup and view all the answers

What type of cells promote the maintenance of dormant hematopoietic stem cells (HSCs) in the bone marrow?

Perivascular and endothelial cells Signup and view all the answers

Which type of stem cells are derived from the inner cell mass of a blastocyst and are pluripotent?

Induced-pluripotent stem cells (iPSCs) Signup and view all the answers

Which stem cell type is found in the subventricular and subgranular zone of the central nervous system?

Neural stem cells (NSCs) Signup and view all the answers

Which of the following tissues contains Langerhans islets and ducts that harbor adult stem cells?

Pancreas Signup and view all the answers

What is the main source of hematopoietic stem cells (HSCs)?

Bone marrow Signup and view all the answers

Which stem cell type is stimulated by disease or injury due to its ability to differentiate into a restricted number of lineages?

Mesenchymal stem cells Signup and view all the answers

What is NOT sufficient to define a stem cell niche according to the text?

Simple location of stem cells Signup and view all the answers