Podcast
Questions and Answers
What is the role of GFAP in the context of stem cells near sinusoidal niches?
What is the role of GFAP in the context of stem cells near sinusoidal niches?
- Encourages megakaryocytes to influence HSCs
- Promotes self-renewal and differentiation of HSCs (correct)
- Induces feedback from macrophages to the niche
- Inhibits HSC migration and proliferation
Which of the following is NOT mentioned as a mechanism to protect adult stem cells and prevent premature aging?
Which of the following is NOT mentioned as a mechanism to protect adult stem cells and prevent premature aging?
- ABC transporters
- Telomerase activity
- DNA repair machinery
- High activity of the enzyme catalase (correct)
What is a characteristic of stem cells regarding toxic substances?
What is a characteristic of stem cells regarding toxic substances?
- Lack of DNA repair machinery to counteract toxic substances
- Inability to efflux toxic substances
- Low levels of telomerase activity to tolerate toxic substances
- High activity of ABC transporters to efflux toxic substances (correct)
Where are less quiescent or activated HSCs primarily located in relation to sinusoidal niches?
Where are less quiescent or activated HSCs primarily located in relation to sinusoidal niches?
What is an example of HSC-derived progeny that can influence HSC migration or proliferation?
What is an example of HSC-derived progeny that can influence HSC migration or proliferation?
What is a protective mechanism for stem cells against premature aging due to the absence of DNA repair machinery?
What is a protective mechanism for stem cells against premature aging due to the absence of DNA repair machinery?
Where do adult stem cells in the intestine reside?
Where do adult stem cells in the intestine reside?
What are the factors that can influence stem cell fate in their niche?
What are the factors that can influence stem cell fate in their niche?
Which cells are responsible for maintaining dormant hematopoietic stem cells (HSCs) in the bone marrow?
Which cells are responsible for maintaining dormant hematopoietic stem cells (HSCs) in the bone marrow?
What is a key structure for the maintenance of adult hematopoietic stem cells (HSCs) in the bone marrow?
What is a key structure for the maintenance of adult hematopoietic stem cells (HSCs) in the bone marrow?
Which signaling pathways are involved in lineage commitment of adult stem cells in the intestine?
Which signaling pathways are involved in lineage commitment of adult stem cells in the intestine?
What type of cells promote the maintenance of dormant hematopoietic stem cells (HSCs) in the bone marrow?
What type of cells promote the maintenance of dormant hematopoietic stem cells (HSCs) in the bone marrow?
Which type of stem cells are derived from the inner cell mass of a blastocyst and are pluripotent?
Which type of stem cells are derived from the inner cell mass of a blastocyst and are pluripotent?
Which stem cell type is found in the subventricular and subgranular zone of the central nervous system?
Which stem cell type is found in the subventricular and subgranular zone of the central nervous system?
Which of the following tissues contains Langerhans islets and ducts that harbor adult stem cells?
Which of the following tissues contains Langerhans islets and ducts that harbor adult stem cells?
What is the main source of hematopoietic stem cells (HSCs)?
What is the main source of hematopoietic stem cells (HSCs)?
Which stem cell type is stimulated by disease or injury due to its ability to differentiate into a restricted number of lineages?
Which stem cell type is stimulated by disease or injury due to its ability to differentiate into a restricted number of lineages?
What is NOT sufficient to define a stem cell niche according to the text?
What is NOT sufficient to define a stem cell niche according to the text?
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