Stem Cell Niche Factors Quiz
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Questions and Answers

What is the role of GFAP in the context of stem cells near sinusoidal niches?

  • Encourages megakaryocytes to influence HSCs
  • Promotes self-renewal and differentiation of HSCs (correct)
  • Induces feedback from macrophages to the niche
  • Inhibits HSC migration and proliferation
  • Which of the following is NOT mentioned as a mechanism to protect adult stem cells and prevent premature aging?

  • ABC transporters
  • Telomerase activity
  • DNA repair machinery
  • High activity of the enzyme catalase (correct)
  • What is a characteristic of stem cells regarding toxic substances?

  • Lack of DNA repair machinery to counteract toxic substances
  • Inability to efflux toxic substances
  • Low levels of telomerase activity to tolerate toxic substances
  • High activity of ABC transporters to efflux toxic substances (correct)
  • Where are less quiescent or activated HSCs primarily located in relation to sinusoidal niches?

    <p>Near the niches</p> Signup and view all the answers

    What is an example of HSC-derived progeny that can influence HSC migration or proliferation?

    <p>Erythropoietin (EPO)</p> Signup and view all the answers

    What is a protective mechanism for stem cells against premature aging due to the absence of DNA repair machinery?

    <p>Telomerase activity</p> Signup and view all the answers

    Where do adult stem cells in the intestine reside?

    <p>Base of the crypt</p> Signup and view all the answers

    What are the factors that can influence stem cell fate in their niche?

    <p>Soluble factors, physicochemical factors, and cell-cell interactions</p> Signup and view all the answers

    Which cells are responsible for maintaining dormant hematopoietic stem cells (HSCs) in the bone marrow?

    <p>Perivascular and endothelial cells</p> Signup and view all the answers

    What is a key structure for the maintenance of adult hematopoietic stem cells (HSCs) in the bone marrow?

    <p>Arterioles</p> Signup and view all the answers

    Which signaling pathways are involved in lineage commitment of adult stem cells in the intestine?

    <p>Wnt and Notch signaling</p> Signup and view all the answers

    What type of cells promote the maintenance of dormant hematopoietic stem cells (HSCs) in the bone marrow?

    <p>Perivascular and endothelial cells</p> Signup and view all the answers

    Which type of stem cells are derived from the inner cell mass of a blastocyst and are pluripotent?

    <p>Induced-pluripotent stem cells (iPSCs)</p> Signup and view all the answers

    Which stem cell type is found in the subventricular and subgranular zone of the central nervous system?

    <p>Neural stem cells (NSCs)</p> Signup and view all the answers

    Which of the following tissues contains Langerhans islets and ducts that harbor adult stem cells?

    <p>Pancreas</p> Signup and view all the answers

    What is the main source of hematopoietic stem cells (HSCs)?

    <p>Bone marrow</p> Signup and view all the answers

    Which stem cell type is stimulated by disease or injury due to its ability to differentiate into a restricted number of lineages?

    <p>Mesenchymal stem cells</p> Signup and view all the answers

    What is NOT sufficient to define a stem cell niche according to the text?

    <p>Simple location of stem cells</p> Signup and view all the answers

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