Stem Cell Niche Interactions Quiz
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Questions and Answers

Which type of stem cells are likely diverse in their influence for self-renewal, proliferation, and differentiation near sinusoidal niches?

  • Adult stem cells (ASCs) (correct)
  • Central nervous system stem cells (NSCs)
  • Stem cells from different tissues (skin, bone marrow, liver, intestine, adipose tissue, pancreas, skeletal muscle tissue)
  • Induced pluripotent stem cells (iPSCs)

Which HSC-derived progeny can feed back to the niche to influence HSC migration or proliferation?

  • Central nervous system stem cells (NSCs)
  • Megakaryocytes
  • Macrophages (correct)
  • Induced pluripotent stem cells (iPSCs)

Which stem cell activity is associated with the enzyme telomerase that has the ability to extend telomeres?

  • Stem cell niche interaction
  • ABC transporters function
  • DNA repair machinery (correct)
  • Quiescence induction

Which protective mechanism for stem cells involves the absence of DNA repair machinery leading to premature aging?

<p>Telomerase activity (C)</p> Signup and view all the answers

Where do signals for erythropoiesis sometimes originate according to the text?

<p>Kidney (D)</p> Signup and view all the answers

Which protein is represented by the abbreviation GFAP in the context of stem cell discussions?

<p>Glial fibrillary acidic protein (C)</p> Signup and view all the answers

What is the source of induced-pluripotent stem cells (iPSCs)?

<p>Adult somatic cells (C)</p> Signup and view all the answers

Which type of stem cells are found in the subgranular zone of the central nervous system?

<p>Neural stem cells (D)</p> Signup and view all the answers

Where are satellite cells, vital for skeletal muscle tissue regeneration, typically found?

<p>Lieberkühn crypts (A)</p> Signup and view all the answers

Which of the following is NOT a source of adult stem cells (ASCs)?

<p>Fetal tissues (D)</p> Signup and view all the answers

What is characteristic of stem cells with low proliferation rate and the ability to differentiate into a restricted number of lineages?

<p>High expression of 'stemness factors' (D)</p> Signup and view all the answers

What is the term for the microenvironment where stem cells reside and interact with surrounding cells and molecules?

<p>Stem cell niche (B)</p> Signup and view all the answers

Where do adult stem cells in the intestine reside?

<p>At the base of the crypt (A)</p> Signup and view all the answers

What factors are involved in modulating stem cell functions in their microenvironment?

<p>Growth factors and cytokines (A)</p> Signup and view all the answers

Which structure has emerged as a key element for the maintenance of hematopoietic stem cells (HSCs) in the bone marrow?

<p>Vasculature (B)</p> Signup and view all the answers

What signaling pathways are involved in the lineage commitment of adult stem cells in the intestine?

<p>Wnt and Notch (C)</p> Signup and view all the answers

Which of the following factors are part of the stem cell niche environment?

<p>Growth factors and cytokines (A)</p> Signup and view all the answers

Where are dormant hematopoietic stem cells (HSCs) typically found in the bone marrow?

<p>Around arterioles (B)</p> Signup and view all the answers

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