Stem Cell Niche Interactions Quiz
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Questions and Answers

Which type of stem cells are likely diverse in their influence for self-renewal, proliferation, and differentiation near sinusoidal niches?

  • Adult stem cells (ASCs) (correct)
  • Central nervous system stem cells (NSCs)
  • Stem cells from different tissues (skin, bone marrow, liver, intestine, adipose tissue, pancreas, skeletal muscle tissue)
  • Induced pluripotent stem cells (iPSCs)
  • Which HSC-derived progeny can feed back to the niche to influence HSC migration or proliferation?

  • Central nervous system stem cells (NSCs)
  • Megakaryocytes
  • Macrophages (correct)
  • Induced pluripotent stem cells (iPSCs)
  • Which stem cell activity is associated with the enzyme telomerase that has the ability to extend telomeres?

  • Stem cell niche interaction
  • ABC transporters function
  • DNA repair machinery (correct)
  • Quiescence induction
  • Which protective mechanism for stem cells involves the absence of DNA repair machinery leading to premature aging?

    <p>Telomerase activity</p> Signup and view all the answers

    Where do signals for erythropoiesis sometimes originate according to the text?

    <p>Kidney</p> Signup and view all the answers

    Which protein is represented by the abbreviation GFAP in the context of stem cell discussions?

    <p>Glial fibrillary acidic protein</p> Signup and view all the answers

    What is the source of induced-pluripotent stem cells (iPSCs)?

    <p>Adult somatic cells</p> Signup and view all the answers

    Which type of stem cells are found in the subgranular zone of the central nervous system?

    <p>Neural stem cells</p> Signup and view all the answers

    Where are satellite cells, vital for skeletal muscle tissue regeneration, typically found?

    <p>Lieberkühn crypts</p> Signup and view all the answers

    Which of the following is NOT a source of adult stem cells (ASCs)?

    <p>Fetal tissues</p> Signup and view all the answers

    What is characteristic of stem cells with low proliferation rate and the ability to differentiate into a restricted number of lineages?

    <p>High expression of 'stemness factors'</p> Signup and view all the answers

    What is the term for the microenvironment where stem cells reside and interact with surrounding cells and molecules?

    <p>Stem cell niche</p> Signup and view all the answers

    Where do adult stem cells in the intestine reside?

    <p>At the base of the crypt</p> Signup and view all the answers

    What factors are involved in modulating stem cell functions in their microenvironment?

    <p>Growth factors and cytokines</p> Signup and view all the answers

    Which structure has emerged as a key element for the maintenance of hematopoietic stem cells (HSCs) in the bone marrow?

    <p>Vasculature</p> Signup and view all the answers

    What signaling pathways are involved in the lineage commitment of adult stem cells in the intestine?

    <p>Wnt and Notch</p> Signup and view all the answers

    Which of the following factors are part of the stem cell niche environment?

    <p>Growth factors and cytokines</p> Signup and view all the answers

    Where are dormant hematopoietic stem cells (HSCs) typically found in the bone marrow?

    <p>Around arterioles</p> Signup and view all the answers

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