Stem Cell Niche Interactions Quiz

Play an AI-generated podcast conversation about this lesson

Which type of stem cells are likely diverse in their influence for self-renewal, proliferation, and differentiation near sinusoidal niches?

Adult stem cells (ASCs) (correct)

Central nervous system stem cells (NSCs)

Stem cells from different tissues (skin, bone marrow, liver, intestine, adipose tissue, pancreas, skeletal muscle tissue)

Induced pluripotent stem cells (iPSCs)

Which HSC-derived progeny can feed back to the niche to influence HSC migration or proliferation?

Central nervous system stem cells (NSCs)

Megakaryocytes

Macrophages (correct)

Induced pluripotent stem cells (iPSCs)

Which stem cell activity is associated with the enzyme telomerase that has the ability to extend telomeres?

Stem cell niche interaction

ABC transporters function

DNA repair machinery (correct)

Quiescence induction

Which protective mechanism for stem cells involves the absence of DNA repair machinery leading to premature aging?

Telomerase activity Signup and view all the answers

Where do signals for erythropoiesis sometimes originate according to the text?

Kidney Signup and view all the answers

Which protein is represented by the abbreviation GFAP in the context of stem cell discussions?

Glial fibrillary acidic protein Signup and view all the answers

What is the source of induced-pluripotent stem cells (iPSCs)?

Adult somatic cells Signup and view all the answers

Which type of stem cells are found in the subgranular zone of the central nervous system?

Neural stem cells Signup and view all the answers

Where are satellite cells, vital for skeletal muscle tissue regeneration, typically found?

Lieberkühn crypts Signup and view all the answers

Which of the following is NOT a source of adult stem cells (ASCs)?

Fetal tissues Signup and view all the answers

What is characteristic of stem cells with low proliferation rate and the ability to differentiate into a restricted number of lineages?

High expression of 'stemness factors' Signup and view all the answers

What is the term for the microenvironment where stem cells reside and interact with surrounding cells and molecules?

Stem cell niche Signup and view all the answers

Where do adult stem cells in the intestine reside?

At the base of the crypt Signup and view all the answers

What factors are involved in modulating stem cell functions in their microenvironment?

Growth factors and cytokines Signup and view all the answers

Which structure has emerged as a key element for the maintenance of hematopoietic stem cells (HSCs) in the bone marrow?

Vasculature Signup and view all the answers

What signaling pathways are involved in the lineage commitment of adult stem cells in the intestine?

Wnt and Notch Signup and view all the answers

Which of the following factors are part of the stem cell niche environment?

Growth factors and cytokines Signup and view all the answers

Where are dormant hematopoietic stem cells (HSCs) typically found in the bone marrow?

Around arterioles Signup and view all the answers