Lecture 7

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Why is controlled oxidation preferred over simple burning in a cell?

It allows for the gradual release of energy that can be captured in a usable form.

What occurs during the breakdown of simple subunits into Acetyl CoA, ATP, and NADH?

Oxidation of Acetyl CoA and substantial ATP production

What is the net result of glycolysis?

Conversion of glucose into pyruvate, ATP, and NADH

Where does glycolysis occur in the cell?

<p>Cytoplasm</p> Signup and view all the answers

What are the 3 stages of glycolysis?

<p>Energy Investment Phase, Cleavage Phase, Energy Liberation Phase</p> Signup and view all the answers

What is the role of the Energy Investment Phase in glycolysis?

<p>Requires ATP to start the process</p> Signup and view all the answers

Which phase of glycolysis involves the conversion of one molecule of glucose into two molecules of pyruvate?

<p>Cleavage Phase</p> Signup and view all the answers

What happens during the Energy Liberation Phase of glycolysis?

<p>Release of energy and production of ATP and NADH</p> Signup and view all the answers

What is the end product of alcohol fermentation?

<p>Ethanol</p> Signup and view all the answers

What is the primary function of a dehydrogenase enzyme?

<p>Removes hydrogen ions and electrons.</p> Signup and view all the answers

How many ATP (net) are produced in lactic acid fermentation from one glucose molecule?

<p>2 ATP</p> Signup and view all the answers

What happens to the products of glycolysis in the presence of oxygen?

<p>Undergo oxidative phosphorylation</p> Signup and view all the answers

Which enzyme adds a phosphate group to a molecule?

<p>Kinase</p> Signup and view all the answers

What is the role of NADH in cellular respiration?

<p>Produces ATP</p> Signup and view all the answers

How do the end products differ between alcohol fermentation and lactic acid fermentation?

<p><strong>End product is ethanol</strong> in alcohol fermentation and <strong>lactic acid in lactic acid fermentation</strong>.</p> Signup and view all the answers

Substrate level phosphorylation involves which process?

<p><strong>Transfer of a phosphate group directly to ADP</strong> from a substrate molecule.</p> Signup and view all the answers

What is the main purpose of cellular respiration?

<p>To break down organic molecules and generate energy in the form of ATP</p> Signup and view all the answers

Which term refers to the gain of electrons by a molecule?

<p>Reduction</p> Signup and view all the answers

What type of reaction involves both oxidation and reduction processes?

<p>Redox reaction</p> Signup and view all the answers

Why does controlled oxidation benefit a cell more than simple burning of a molecule?

<p>Controlled oxidation prevents damage to the cell through uncontrolled reactions</p> Signup and view all the answers

What is the main difference between catabolism and anabolism?

<p>Catabolism releases energy, while anabolism requires energy input</p> Signup and view all the answers

During which process does a molecule experience a decrease in its oxidation state?

<p>Reduction</p> Signup and view all the answers

In a redox reaction, what often comes along with an electron when it is picked up?

<p>(H+) Proton (Hydrogen Ion)</p> Signup and view all the answers

Which term describes the synthesis of complex molecules from simpler ones?

<p>Anabolism</p> Signup and view all the answers

How does catabolism differ from anabolism?

<p>Catabolism releases energy, while anabolism requires energy input.</p> Signup and view all the answers

During which process does a molecule experience an increase in its oxidation state?

<p>Oxidation</p> Signup and view all the answers

During the Energy Investment Phase of glycolysis, ATP is required to start the process.

<p>True</p> Signup and view all the answers

Substrate level phosphorylation occurs during the Cleavage Phase of glycolysis.

<p>False</p> Signup and view all the answers

NADH production is a key outcome of the Energy Investment Phase in glycolysis.

<p>False</p> Signup and view all the answers

The Energy Liberation Phase of glycolysis involves the conversion of glucose into pyruvate.

<p>True</p> Signup and view all the answers

In glycolysis, the Cleavage Phase is where ATP is generated from ADP and Pi.

<p>False</p> Signup and view all the answers

The Energy Investment Phase of glycolysis involves breaking down glucose into smaller molecules.

<p>False</p> Signup and view all the answers

NADH is a high-energy molecule that carries electrons to the electron transport chain.

<p>True</p> Signup and view all the answers

During the Cleavage Phase of glycolysis, a six-carbon glucose molecule is split into four three-carbon molecules.

<p>False</p> Signup and view all the answers

Substrate level phosphorylation results in the direct formation of ATP from ADP and Pi.

<p>True</p> Signup and view all the answers

Substrate level phosphorylation in glycolysis involves the direct transfer of a phosphate group to ADP from a substrate molecule.

<p>True</p> Signup and view all the answers

NADH production in glycolysis requires NADP as a precursor.

<p>False</p> Signup and view all the answers

Kinase is an enzyme that converts a molecule into its isomer.

<p>False</p> Signup and view all the answers

Dehydrogenase enzyme removes hydrogen ions and electrons.

<p>True</p> Signup and view all the answers

In the absence of oxygen, the products of glycolysis can undergo fermentation to generate only CO2.

<p>False</p> Signup and view all the answers

Alcohol fermentation produces lactic acid as its end product.

<p>False</p> Signup and view all the answers

Lactic Acid Fermentation produces more energy (ATP) per glucose molecule than Alcohol Fermentation.

<p>False</p> Signup and view all the answers

During the Energy Investment Phase of glycolysis, ATP molecules are consumed to phosphorylate glucose.

<p>True</p> Signup and view all the answers

The Cleavage Phase of glycolysis involves the conversion of one molecule of glucose into two molecules of pyruvate.

<p>True</p> Signup and view all the answers

During the Energy Liberation Phase of glycolysis, NADH is produced.

<p>False</p> Signup and view all the answers

Substrate-level phosphorylation in glycolysis involves the direct transfer of a phosphate group from a substrate to ADP, forming ATP.

<p>True</p> Signup and view all the answers

The production of NADH in glycolysis occurs primarily during the Cleavage Phase.

<p>False</p> Signup and view all the answers

In glycolysis, the Energy Investment Phase precedes the Cleavage Phase.

<p>True</p> Signup and view all the answers

The Energy Liberation Phase of glycolysis results in the net production of ATP.

<p>True</p> Signup and view all the answers

NAD+ is reduced to NADH during some steps of glycolysis.

<p>True</p> Signup and view all the answers

The production of NADH in glycolysis involves the oxidation of NAD+.

<p>False</p> Signup and view all the answers

Substrate-level phosphorylation in glycolysis occurs only once per glucose molecule.

<p>False</p> Signup and view all the answers

During the Energy Investment Phase of glycolysis, ATP molecules are consumed to phosphorylate ______

<p>glucose</p> Signup and view all the answers

The Energy Liberation Phase of glycolysis generates ATP and ______, producing pyruvate molecules at the end

<p>NADH</p> Signup and view all the answers

Substrate level phosphorylation involves the transfer of a phosphate group directly to ADP from a ______ molecule

<p>substrate</p> Signup and view all the answers

NADH is needed in order for NADH to be produced in glycolysis. The cell uses NADH in oxidative phosphorylation to produce ______

<p>ATP</p> Signup and view all the answers

The Cleavage Phase of glycolysis splits the six-carbon glucose molecule into two ______-carbon molecules

<p>three</p> Signup and view all the answers

The Energy Investment Phase of glycolysis involves breaking down ______ into smaller molecules

<p>glucose</p> Signup and view all the answers

Substrate level phosphorylation in glycolysis involves the direct transfer of a phosphate group from a ______ to ADP, forming ATP

<p>substrate</p> Signup and view all the answers

NADH production in glycolysis requires ______ as a precursor

<p>NAD+</p> Signup and view all the answers

The Energy Investment Phase of glycolysis requires ______ to start the process.

<p>ATP</p> Signup and view all the answers

During the Energy Liberation Phase of glycolysis, the net production of ______ occurs.

<p>ATP</p> Signup and view all the answers

The Cleavage Phase of glycolysis involves the conversion of one molecule of glucose into two molecules of ______.

<p>pyruvate</p> Signup and view all the answers

NADH production is a key outcome of the Energy Investment Phase in glycolysis. NADH is a high-energy molecule that carries ______ to the electron transport chain.

<p>electrons</p> Signup and view all the answers

Substrate-level phosphorylation in glycolysis involves the direct transfer of a phosphate group to ADP from a ______ molecule.

<p>substrate</p> Signup and view all the answers

During glycolysis, the breakdown of simple subunits into Acetyl CoA, ATP, and NADH occurs in the ______.

<p>cytosol</p> Signup and view all the answers

In glycolysis, the Energy Investment Phase precedes the ______ Phase.

<p>Cleavage</p> Signup and view all the answers

The net result of glycolysis is the conversion of one molecule of glucose into two molecules of pyruvate, along with the production of ______ and NADH.

<p>ATP</p> Signup and view all the answers

During the Energy Investment Phase of glycolysis, __________ is required to start the process

<p>ATP</p> Signup and view all the answers

The Energy Liberation Phase of glycolysis results in the net production of _________

<p>ATP</p> Signup and view all the answers

The Cleavage Phase of glycolysis involves the conversion of one molecule of glucose into two molecules of _________

<p>pyruvate</p> Signup and view all the answers

NADH production in glycolysis occurs primarily during the _________ Phase

<p>Cleavage</p> Signup and view all the answers

Substrate level phosphorylation in glycolysis involves the direct transfer of a phosphate group to ADP from a _________ molecule

<p>substrate</p> Signup and view all the answers

During glycolysis, the Energy Investment Phase precedes the _________ Phase

<p>Cleavage</p> Signup and view all the answers

_________ involves the direct formation of ATP from ADP and Pi

<p>Substrate level phosphorylation</p> Signup and view all the answers

In glycolysis, the Cleavage Phase is where ATP is generated from ADP and Pi through _________

<p>phosphorylation</p> Signup and view all the answers

NADH is a high-energy molecule that carries electrons to the _________ transport chain

<p>electron</p> Signup and view all the answers

The net result of glycolysis includes the production of ATP and _________

<p>pyruvate</p> Signup and view all the answers

Which stage involves the breakdown of simple subunits into Acetyl CoA, ATP, and NADH in the cytosol?

<p>Stage 2</p> Signup and view all the answers

What is the primary function of anabolism?

<p>Build macromolecules</p> Signup and view all the answers

During which stage of metabolism does controlled oxidation primarily occur?

<p>Catabolism</p> Signup and view all the answers

What is the end product of lactic acid fermentation?

<p>Lactic Acid</p> Signup and view all the answers

Which type of phosphorylation involves the direct transfer of a phosphate group to ADP from a substrate molecule?

<p>Substrate-level phosphorylation</p> Signup and view all the answers

What does catabolism primarily involve?

<p>Breakdown of complex molecules to release energy</p> Signup and view all the answers

Which process results in the production of more energy (ATP) per glucose molecule: Lactic acid fermentation or Alcohol fermentation?

<p>Lactic Acid Fermentation</p> Signup and view all the answers

What is the net outcome of glycolysis in terms of ATP produced?

<p>$2$ ATP produced</p> Signup and view all the answers

Where do the 3 stages of food molecule breakdown take place?

<p>Breakdown - Oxidation - Mitochondria</p> Signup and view all the answers

Can all energy come from sugar alone?

<p>No, fats and proteins can also be used for energy</p> Signup and view all the answers

What are the precursors to ATP and NADH?

<p>NAD+</p> Signup and view all the answers

Is NADH a reduced or oxidized molecule?

<p>Reduced</p> Signup and view all the answers

What is the process of converting non-sugar precursors into glucose known as?

<p>Gluconeogenesis</p> Signup and view all the answers

Where does glycolysis take place?

<p>Cytoplasm</p> Signup and view all the answers

How many phases are there in glycolysis?

<p>3</p> Signup and view all the answers

What is the end product of glycolysis?

<p>$ ext{Pyruvate}$</p> Signup and view all the answers

In the absence of oxygen in cells unable to perform fermentation, which product of glycolysis would accumulate in the cytosol?

<p>Pyruvate</p> Signup and view all the answers

Which step of glycolysis would be halted in mutated muscle cells unable to perform fermentation in anoxic conditions?

<p>Conversion of glucose to pyruvate</p> Signup and view all the answers

What is the end product of processing pyruvate anaerobically?

<p>Lactic acid and ethanol</p> Signup and view all the answers

Which process occurs when a mutated muscle cell is unable to perform fermentation in anoxic conditions?

<p>Glycolysis</p> Signup and view all the answers

What is the primary difference between alcohol fermentation and lactic acid fermentation?

<p>End products produced</p> Signup and view all the answers

Which molecule is a common precursor for both glycolysis and gluconeogenesis?

<p>Pyruvate</p> Signup and view all the answers

What is the role of fermentation in the absence of oxygen for cells unable to perform it?

<p>Regenerate NAD+</p> Signup and view all the answers

What is the process that allows for the conversion of pyruvate to lactate, regenerating NAD from NADH, in the absence of oxygen?

<p>Fermentation</p> Signup and view all the answers

In the context of muscle atrophy in rats, why did researchers observe an increase in gluconeogenesis in the liver?

<p>Increased energy demands due to muscle atrophy</p> Signup and view all the answers

What is the significance of increased fructose 1,6-bisphosphatase activity in the liver of rats with hind-limb mobility restored?

<p>Decreased gluconeogenesis</p> Signup and view all the answers

Which metabolic process is most likely to be upregulated when there is insufficient oxygen available for aerobic respiration?

<p>Glycolysis</p> Signup and view all the answers

What happens to pyruvate in the absence of oxygen and without the ability to metabolize further?

<p>Undergoes fermentation to lactate</p> Signup and view all the answers

Which of the following is a storage form of energy that can be metabolized for cellular purposes?

<p>Glycogen</p> Signup and view all the answers

What results from the fermentation process converting pyruvate into ethanol?

<p>Regeneration of NAD</p> Signup and view all the answers

Why is an increase in fructose 1,6-bisphosphatase activity crucial for gluconeogenesis during periods of high energy demand?

<p>To promote gluconeogenic carbon flow</p> Signup and view all the answers

During which phase of glycolysis are 2 molecules of glyceraldehyde-3-phosphate (G3P) produced?

<p>Cleavage phase</p> Signup and view all the answers

What is the main purpose of the energy recovery/generation phase in glycolysis?

<p>To produce ATP and pyruvate</p> Signup and view all the answers

Which type of respiration pathway is known as anaerobic respiration?

<p>Glycolysis</p> Signup and view all the answers

In cellular metabolism, what is the primary function of catabolism?

<p>To break down large molecules into smaller units</p> Signup and view all the answers

Why do cells not directly burn sugar for energy?

<p>Direct burning is too slow to produce ATP efficiently</p> Signup and view all the answers

What is the significance of stepwise oxidation in cellular respiration?

<p>To prevent the buildup of toxic intermediates</p> Signup and view all the answers

What is the main difference between catabolism and anabolism in cellular metabolism?

<p>Catabolism involves breaking down, while anabolism involves building up molecules</p> Signup and view all the answers

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