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Questions and Answers

What was the primary cause of death 100 years ago?

  • Accidents and injuries
  • Infectious diseases (correct)
  • Cancer
  • Cardiovascular diseases
  • Which antibacterial drugs were first used extensively during WWII?

  • Vancomycin
  • Sulfa drugs (correct)
  • Amoxicillin
  • Penicillin
  • Who is credited with the discovery of Penicillin?

  • Howard Florey
  • Louis Pasteur
  • Ernst Boris Chain
  • Alexander Fleming (correct)
  • What type of bacteria does Penicillin primarily target?

    <p>Gram-positive bacteria (D)</p> Signup and view all the answers

    What mechanism does Penicillin use to inhibit bacteria?

    <p>Inhibiting cell wall formation (B)</p> Signup and view all the answers

    What is a major consequence of the overuse of antibiotics?

    <p>Development of antibiotic-resistant strains (C)</p> Signup and view all the answers

    Which of the following is a common side effect of antibiotic use?

    <p>Resistance in microorganisms (A)</p> Signup and view all the answers

    Amoxicillin is known for its broad activity against which type of organisms?

    <p>Many types of microorganisms (C)</p> Signup and view all the answers

    Why are higher animals not affected by Penicillin?

    <p>They lack bacterial cell walls (D)</p> Signup and view all the answers

    What significant issue has emerged alongside the use of antibiotics?

    <p>Development of drug-resistant tuberculosis (C)</p> Signup and view all the answers

    What is the primary function of nucleoside reverse transcriptase inhibitors (NRTIs)?

    <p>Substitute an analog for a nucleoside in viral DNA (B)</p> Signup and view all the answers

    Which category of antiretroviral drugs specifically stops reverse transcriptase from functioning correctly?

    <p>Non-nucleoside reverse transcriptase inhibitors (NNRTIs) (B)</p> Signup and view all the answers

    What mechanism do protease inhibitors use to combat retroviral infections?

    <p>Preventing protease from functioning (B)</p> Signup and view all the answers

    Which condition is associated with atherosclerosis and is primarily caused by it?

    <p>Myocardial infarction (D)</p> Signup and view all the answers

    Which of the following diseases is caused by a virus and cannot be treated with antibiotics?

    <p>Influenza (B)</p> Signup and view all the answers

    What is considered normal blood pressure according to the standards provided?

    <p>120/80 mmHg (D)</p> Signup and view all the answers

    Which of the following is NOT one of the four major categories of drugs for lowering blood pressure?

    <p>Calcium channel blockers (D)</p> Signup and view all the answers

    What is the main reason that antibiotics are ineffective against viral infections?

    <p>Viruses do not have cell walls. (C)</p> Signup and view all the answers

    What type of virus is the Human Immunodeficiency Virus (HIV)?

    <p>Retrovirus (B)</p> Signup and view all the answers

    What is the major goal of drug treatments for heart diseases?

    <p>Normalize heart rhythm and increase blood supply (C)</p> Signup and view all the answers

    Which of the following statements about vaccinations is true?

    <p>Influenza vaccines are effective against common strains of flu viruses. (C)</p> Signup and view all the answers

    Which of the following statements about hypertension is true?

    <p>It is typically considered high blood pressure above 140/90 mmHg. (C)</p> Signup and view all the answers

    Which class of drug is Didanosine (ddI)?

    <p>Nucleoside reverse transcriptase inhibitor (A)</p> Signup and view all the answers

    What is the role of antiretroviral drugs?

    <p>To prevent the reproduction of retroviruses (D)</p> Signup and view all the answers

    How do RNA viruses replicate within a host cell?

    <p>By inducing host cell RNA synthesis (C)</p> Signup and view all the answers

    Saquinavir is classified as what type of antiviral drug?

    <p>Protease inhibitor (C)</p> Signup and view all the answers

    What is the primary function of diuretics in lowering blood pressure?

    <p>Increasing the excretion of water by the kidneys (A)</p> Signup and view all the answers

    What happens when T cells are destroyed by HIV?

    <p>The immune response becomes less effective. (D)</p> Signup and view all the answers

    Which type of drug is responsible for slowing down both physical and mental activities?

    <p>Depressant (B)</p> Signup and view all the answers

    What type of infection is Tamiflu® used to prevent?

    <p>Viral infections, particularly influenza (D)</p> Signup and view all the answers

    What is the effect of cocaine on dopamine levels in the brain?

    <p>Decreases dopamine re-uptake (B)</p> Signup and view all the answers

    Which of the following is NOT classified as a depressant drug?

    <p>Caffeine (C)</p> Signup and view all the answers

    What is a common long-term effect of methamphetamine use?

    <p>Severe mental problems (C)</p> Signup and view all the answers

    Which class of drugs is known to induce changes in sensory perception?

    <p>Hallucinogenic drugs (D)</p> Signup and view all the answers

    Which neurotransmitters are elevated by stimulant drugs?

    <p>Dopamine, serotonin, and norepinephrine (A)</p> Signup and view all the answers

    Which combination of drugs creates a synergistic effect that can be extremely dangerous?

    <p>Ethanol and barbiturates (D)</p> Signup and view all the answers

    What substance was accidentally discovered by Albert Hofmann in 1943?

    <p>LSD (D)</p> Signup and view all the answers

    Which drug is especially powerfully addictive and has a lethal dose estimated at about 50 mg?

    <p>Nicotine (A)</p> Signup and view all the answers

    What is the primary purpose of the drug development process?

    <p>To identify drug candidates for treating diseases (D)</p> Signup and view all the answers

    Which of the following is NOT a reason why people use drugs?

    <p>To enhance creativity (A)</p> Signup and view all the answers

    What typically happens to a drug once its patent expires?

    <p>Generic versions can be produced and sold (A)</p> Signup and view all the answers

    What role do prostaglandins play in relation to NSAIDs?

    <p>They send pain messages to the brain (D)</p> Signup and view all the answers

    Which of the following is a characteristic of narotics?

    <p>Effective but can cause stupor or general anaesthesia (B)</p> Signup and view all the answers

    Which method begins drug development by identifying biological molecules related to a disease?

    <p>Rational drug design (D)</p> Signup and view all the answers

    What is a primary side effect of NSAIDs?

    <p>Excessive bleeding and stomach pains (D)</p> Signup and view all the answers

    What is the main effect of morphine and its derivatives?

    <p>They are primarily used for severe pain relief (C)</p> Signup and view all the answers

    What is one way in which heroin differs from codeine?

    <p>Heroin induces addiction more quickly than codeine (D)</p> Signup and view all the answers

    Which of the following substances is primarily used for cough suppression?

    <p>Codeine (B)</p> Signup and view all the answers

    What is a common application of high-throughput screening in drug development?

    <p>Screening thousands of compounds for biological activity (B)</p> Signup and view all the answers

    What motivates the chemical modification of existing drugs?

    <p>To improve drug efficacy and minimize side effects (B)</p> Signup and view all the answers

    Why might NSAIDs not be suitable for people undergoing surgery?

    <p>They can increase the risk of excessive bleeding (B)</p> Signup and view all the answers

    Flashcards

    Drugs

    Chemical substances that alter the functioning of living things.

    Drug Development

    The process of discovering, testing, and approving new drugs for medical use.

    Rational Drug Design

    Finding a biological molecule involved in a disease and then designing molecules to interact with it.

    High-Throughput Screening

    Using robots to screen thousands of compounds for potential drug activity.

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    Clinical Trials

    Testing drug candidates in humans to assess efficacy and safety.

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    Placebo

    An inert substance used as a control in drug trials to compare against the actual drug.

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    Patent Protection

    Exclusive rights granted to a company to manufacture and sell a drug for a specific period.

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    Generic Drugs

    Chemically equivalent copies of patented drugs produced after the patent expires.

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    Aspirin

    An analgesic, antipyretic, and anti-inflammatory drug derived from willow bark.

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    Non-steroidal Anti-inflammatory Drugs (NSAIDs)

    Drugs that relieve pain and reduce inflammation by inhibiting prostaglandin production.

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    Prostaglandins

    Hormone-like lipids involved in transmitting pain signals to the brain.

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    Narcotics

    Prescription drugs that produce strong pain relief but can be addictive.

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    Morphine

    A natural opioid derived from opium, used for severe pain relief but highly addictive.

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    Codeine

    A morphine derivative less potent and addictive than morphine.

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    Heroin

    A highly addictive drug derived from morphine, inducing a quick and intense high but causing severe withdrawal symptoms.

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    Antibacterial Drugs

    Medicines that fight bacterial infections, helping to control diseases that were once major death causes.

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    Sulfa Drugs

    One of the first antibacterial drugs, widely used during WWII to prevent infections in wounds.

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    Antibiotics

    Substances derived from molds and fungi that kill other microbes. Penicillin is a famous example.

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    Penicillin Discovery

    Alexander Fleming accidentally discovered penicillin in 1928, but its medical use started in 1941.

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    Penicillin Mechanism

    Penicillin inhibits bacterial enzymes involved in building their cell walls, causing them to weaken and rupture.

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    Penicillin's Broad Spectrum

    Penicillin includes different compounds with varying effectiveness against different types of bacteria.

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    Antibiotic Resistance

    A serious problem where bacteria evolve, becoming resistant to antibiotics.

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    Antibiotic Gene Sharing

    Resistant bacteria can share their genes, spreading antibiotic resistance to other bacteria.

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    Tuberculosis (TB)

    An infectious disease that had been controlled but is now a threat due to drug-resistant strains.

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    Impact of Antibiotic Resistance

    Antibiotic resistance is a significant threat to global health, potentially leading to untreatable infections.

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    What is drug resistance?

    The ability of a microbe (like bacteria or virus) to survive and multiply despite the presence of a drug that is designed to kill or inhibit it.

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    Virus vs. Bacteria

    Viruses are much smaller than bacteria and require a host cell to reproduce. Bacteria are single-celled organisms that can reproduce independently.

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    Why don't antibiotics work on viruses?

    Antibiotics specifically target bacterial processes. Viruses have different mechanisms for replication and don't have the same targets that antibiotics attack.

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    DNA Virus

    A virus that uses DNA as its genetic material. It enters a host cell and hijacks the cell's machinery to replicate its own DNA and produce viral proteins.

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    RNA Virus

    A virus that uses RNA as its genetic material. It enters a host cell and forces the cell to produce viral proteins using its own RNA.

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    Retrovirus

    A type of RNA virus that has the unique ability to create DNA from its RNA using an enzyme called reverse transcriptase.

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    Antiviral Drug

    A drug that specifically targets and inhibits the replication of viruses, but does not cure viral infections.

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    Nucleoside Analog

    A drug that resembles the building blocks of DNA or RNA. It interferes with the virus's ability to create its own DNA or RNA.

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    Protease Inhibitor

    A drug that blocks the activity of viral enzymes called proteases, which are essential for the virus to assemble new viral particles.

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    Reverse Transcriptase Inhibitors (RTIs)

    A category of antiretroviral drugs that target the enzyme reverse transcriptase, preventing the conversion of viral RNA into DNA.

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    Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)

    Antiretroviral drugs that bind to reverse transcriptase and stop it from working properly.

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    Atherosclerosis

    The buildup of fatty deposits, or plaques, in the lining of arteries, leading to narrowing and hardening of the arteries.

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    Myocardial Infarction (Heart Attack)

    Occurs when a coronary artery becomes blocked, depriving a portion of the heart muscle of oxygen and causing damage.

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    Hypertension (High Blood Pressure)

    A condition where the pressure of blood against the walls of arteries is consistently too high.

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    Drugs for Heart Diseases

    Medications designed to manage conditions like coronary artery disease, arrhythmias, hypertension, and congestive heart failure.

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    Diuretics

    Drugs that lower blood pressure by causing the kidneys to excrete more water, reducing blood volume.

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    Beta Blockers

    Drugs that lower blood pressure by slowing the heart rate and reducing the force of each heartbeat.

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    Calcium Channel Blockers

    Powerful vasodilators that relax muscles around blood vessels, widening them and lowering blood pressure.

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    ACE Inhibitors

    Drugs that inhibit the action of an enzyme that causes blood vessels to contract, thus lowering blood pressure.

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    Psychotropic Drug

    A drug that affects the human mind, changing mood, perception, and behavior.

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    Stimulant Drug

    A drug that speeds up the central nervous system, increasing alertness, energy, and mood.

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    Depressant Drug

    A drug that slows down the central nervous system, reducing anxiety, alertness, and physical activity.

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    Hallucinogenic Drug

    A drug that alters sensory perception, creating hallucinations and changes in consciousness.

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    Synergistic Effect

    When the combined effect of two or more drugs is greater than the sum of their individual effects.

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    LSD

    A powerful hallucinogen discovered accidentally by Albert Hofmann in 1943.

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    Study Notes

    UGEB2380: The Chemistry of Life (2024-25)

    • Course title: The Chemistry of Life
    • Academic year: 2024-2025
    • Instructor: Dr. Sam CK HAU (Department of Chemistry)

    Medicines and Drugs

    • Definition: Chemical substances affecting living things' functions.
    • Usage: Treat, diagnose, and prevent diseases.
    • Reasons for use: Relieving pain, fighting infections, staying awake, calming anxiety, preventing conception, and treating various conditions (from arthritis to cancer).
    • Extensive use: Over 4 billion prescriptions annually in the US, exceeding $320 billion in sales.

    Drug Development

    • Process: Identifying drug candidates (chemical compounds with biological activity) using various methods.
    • Methods:
      • Rational drug design: Identifying biological molecules involved in a disease and designing molecules to interact with those targets.
      • High-throughput screening: Employing robotics to screen thousands of compounds.
      • Serendipity or chance: Accidental discoveries.
      • Chemical modification of existing drugs: Improving efficacy and/or reducing side effects.
    • FDA approval process: Thousands of compounds are screened and tested before receiving marketing approval. The process is time-consuming, often taking 15 or more years.
    • Clinical trials are expensive, involving human subjects and comparing the drug to a placebo (an inert substance used as a control).
    • Drug protection: New drugs are initially protected by patents, preventing other companies from producing and selling similar drugs. This protection ends when the patent expires. Afterwards, generic drugs (chemically equivalent but less expensive) can enter the market.
    • Time scale: The period for development can vary.

    Nonprescription Pain Relievers

    • Semi-synthetic drugs: Made by chemically modifying natural products (late 19th century).
    • Natural products: Chemical compounds produced by living organisms.
    • Example: Aspirin, with more than 2400 years of history and used by ancient physicians (such as Hippocrates) to ease pain and lower fever.
    • Active ingredient: Willow leaves (isolated as active ingredient in 1835).

    Aspirin

    • Active ingredient isolated from willow leaves in 1835.
    • Effective analgesic (pain reliever), antipyretic (fever reducer), and anti-inflammatory.
    • Side effects: Stomach distress and bleeding.
    • Introduced by Bayer in 1893.

    Non-steroidal Anti-inflammatory Drugs (NSAIDs)

    • Examples: Aspirin, ibuprofen, naproxen, and ketoprofen.
    • Mechanism: Inhibit the production of prostaglandins (hormone-like lipids that send pain signals to the brain). This is less about curing the problem and more about blocking the messenger.
    • Side effects: Can affect blood platelets, kidneys, and stomach lining, potentially causing excessive bleeding and stomach pain.
    • Usage restrictions for surgery, childbirth, or other situations where blood loss poses a danger.

    Narcotics

    • Definition: Stronger prescription drugs used for severe pain relief.
    • Mechanism: Produce narcosis (stupor or general anesthesia), analgesia (pain relief), and are often addictive.
    • Historical source: Opium from the dried, resinous juice of unripe poppy seeds (Morphine is the extracted compound).
    • Side effects: Constipation, lethargy, drowsiness, confusion, euphoria, chronic constipation, and depression of the respiratory system.

    Morphine

    • Isolation date: 1805.
    • Historical use: Widely used in wars for pain relief, often due to battle wounds.
    • One major side effect: Constipation and addiction.
    • Current usage: Prescribed for severe pain relief, but often accompanies side effects like lethargy, drowsiness, confusion, euphoria, chronic constipation and depression of the respiratory system.

    Morphine Derivatives

    • Codeine: Similar to morphine but less potent, with less tendency to induce sleep and less addictive. Used in cough suppressants.
    • Heroin: More potent than codeine and morphine, and harder to treat as an addiction. It's made from a conversion of morphine, inducing addiction more quickly.

    Drugs and Infectious Diseases

    • Infectious diseases' impact: Declined as a primary cause of death through the use of antibacterial medication.
    • Antibacterial drugs: Sulfa drugs were widely used in World War II.
    • Overall: Improved treatment of infectious diseases.

    Antibiotics

    • Source of the drugs: Moulds and fungi.
    • Discovery of Penicillin: By Alexander Fleming in 1928.
    • Development: Further development of Penicillin, purification, and improvements by scientists including Florey and Chain.
    • Mechanisms: Inhibit enzymes needed for bacterial cell wall synthesis, causing holes to form in the wall and leading to the death of the bacteria.

    Penicillin

    • Class of drug: Antimicrobial (kills microbes).
    • Not a single substance but a range of related compounds, with varied effectiveness.
    • Administered forms: Orally and by injection.
    • Applications: Widely used in prescription.
    • Spectrum of activity: Against many microorganisms (broad spectrum).

    How Antibiotics Work

    • Bacterial targets: Enzymes used for cell wall synthesis.
    • Mechanism: Penicillin inhibits the enzymes involved in cross-linking between bacterial cell wall molecules (mucoproteins). This forces holes to appear in the cell walls, causing the bacteria to swell and rupture.
    • Effect on higher animals: Higher animals' cells do not have cell walls. Penicillin does not harm these cells.

    Antibiotics and Drug Resistance

    • Resistance development: Bacteria develop strains resistant to antibiotics by sharing genes for antibiotic resistance and producing copies of resistant strains.
    • Implications for health: Drug resistance is a significant threat to global health.

    Viruses

    • Treatment: Cannot be cured by antibiotics. This is because antibiotics work to kill bacteria, not viruses.
    • Prevention: Vaccines are often quite effective in preventing viral infections.
    • Example: Influenza (flu) vaccines.

    DNA and RNA Viruses

    • Structure: Composed of nucleic acids and proteins (some RNA viruses have a lipid membrane).
    • Reproduction: DNA viruses replicate in the host cell's nucleus, directing the cell to produce viral proteins; the viral proteins and viral DNA assemble into new viruses and released.
    • Replication: RNA viruses replicate in the host cell's cytoplasm, often through an enzyme which converts DNA to RNA (reverse transcriptase).
    • Different effects: The two viral types have different methods of reproducing.

    Antiviral Drugs

    • Role: Effective against some viruses, but not a cure.
    • Examples: Various drugs, including nucleoside analogs.

    Antiretroviral Drugs

    • Target retroviruses (example: HIV).
    • Types:
      • Nucleoside reverse transcriptase inhibitors (NRTIs): Substitute analogs for nucleosides in the viral DNA, preventing proper replication.
      • Non-nucleoside reverse transcriptase inhibitors (NNRTIs): Prevent reverse transcriptase from working properly.
      • Protease inhibitors: Block the enzyme protease, preventing the creation of new retroviruses.

    Drugs for the Heart

    • Cardiovascular diseases: Responsible for a significant portion of deaths worldwide.
    • Main categories of heart disease:
      • Ischemic coronary artery disease (lack of oxygen supply).
      • Arrhythmias (irregular heartbeats).
      • Hypertension (high blood pressure).
      • Congestive heart failure.
    • Atherosclerosis (build-up of fatty deposits in the artery walls): Causes coronary artery disease.
    • Drug treatments: Increase blood and oxygen supply, normalize heart rhythm, lower blood pressure, and prevent lipid plaque deposits in the vessels.

    Lowering Blood Pressure

    • Measurement: Blood pressure is measured in mmHg (millimeters of mercury).
    • Categories of drugs:
      • Diuretics: Excrete more water.
      • Beta blockers: Slow heart rate and decrease force of contraction.
      • Calcium channel blockers: Relax blood vessels.
      • ACE inhibitors: Inhibit an enzyme that causes vessel constriction.

    Drugs and the Mind

    • Psychotropic drugs: Affect the mind and/or body.
    • Types of psychotropic drugs:
      • Stimulant drugs: Increase alertness, speed mental processes.
      • Depressant drugs: Slow down both physical and mental activity.
      • Hallucinogenic drugs: Induce qualitative changes in sensory perception.

    Stimulant Drugs

    • Source: Plant alkaloids.
    • Examples:
      • Cocaine: Readily absorbed by the mucous membrane of the nose, leading to increased dopamine levels.
      • Caffeine: Mildly addictive; less harmful.
      • Nicotine: Highly addictive.
    • Other stimulants: Amphetamines, methylphenidate (Ritalin), and others.

    Depressant Drugs

    • Effect: Reduce the level of consciousness and intensity of reactions to environmental stimuli.
    • Examples:
      • Alcohol (ethanol): Slows down physical and mental activity, often with a strong potential for abuse.
      • Barbiturates: Used as sleeping pills.
      • Tranquilizers: Reduce anxiety; some are used as sleeping pills.

    Hallucinogenic Drugs

    • Effect: Causes changes in sensory perception; qualitatively altering the way users perceive things.
    • Types:
      • Natural: Psilocybin mushrooms.
      • Synthetic: MDMA (Ecstasy), DMT, PCP, ketamine.
      • Semisynthetic: LSD (lysergic acid diethylamide), mescaline.
    • LSD: Accidentally discovered by chemist Albert Hofmann in 1943.

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