Spitz Nevi Characteristics

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Small, hyperchromatic nuclei with irregular shapes.
Absence of eosinophilic cytoplasm around melanocytic cells.
Elongated, spindle-shaped cells arranged in fascicles.
Melanocytic cells with large epithelioid nuclei and prominent nucleoli. (correct)

Invasion of subcutaneous fat by melanocytic cells.
Asymmetrical growth pattern with poorly defined borders.
Well-circumscribed and symmetric appearance from side to side and top to bottom. (correct)
Complete absence of a dermal component.

In Spitz nevi, cells become larger with increasing depth, while in melanoma, they remain uniform.
In Spitz nevi, cells show progressive maturation, becoming smaller with increasing depth; melanoma cells lack this maturation. (correct)
Melanoma cells exhibit progressive maturation, while Spitz nevus cells do not.
Both Spitz nevi and melanoma show a similar pattern of melanocytic cell maturation.

Wedge shaped, with narrowing of the wedge toward the subcutaneous fat. (D) Signup and view all the answers

Small intraepidermal eosinophilic globules found in Spitz nevi. (A) Signup and view all the answers

PAS positive, diastase resistant. (A) Signup and view all the answers

Well-nested arrangement, with possible permeation by single cells or small groups. (B) Signup and view all the answers

In the center of the lesion. (C) Signup and view all the answers

Artifactual clefts between melanocytic nests and the epidermis. (C) Signup and view all the answers

Vertical streaming of cells. (B) Signup and view all the answers

Melanocytic nevus with large epithelioid nuclei, prominent nucleoli, and ground-glass cytoplasm.

Melanocytic cells mature progressively with depth, becoming smaller.

Resembling colloid bodies, can be found in the epidermis.

Epidermal permeation by single cells or small groups may occur, more common in the center of the lesion.

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Spitz nevi are marked by melanocytic cells that have large epithelioid nuclei.
Nucleoli are often prominent within the melanocytic cells.
These cells are surrounded by a rim of eosinophilic cytoplasm, giving a "ground-glass" appearance.
These lesions are well-defined and symmetrical in all dimensions.
Unlike melanoma, the melanocytic cells in Spitz nevi mature as they go deeper becoming smaller.
The overall distribution of cells in the dermis is wedge-shaped, narrowing towards the subcutaneous fat.
Purely junctional and dermal lesions can also occur.
Epidermal hyperplasia is common when there's a junctional component.
Small, intraepidermal eosinophilic globules (Kamino bodies) may be present.
Kamino bodies are positive for periodic acid–Schiff and diastase resistant, resembling colloid bodies.
Melanocytic elements are usually well nested.
Single cells or small groups of cells may permeate the epidermis.
Pagetoid cells are more commonly found in the center of the lesion.
Artifactual clefts often appear between melanocytic nests and the epidermis.
Ovoid junctional nests often display vertical streaming of the constituent cells.