أسئلة الثانية امبريولوجي (قبل التعديل)
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Questions and Answers

What characterizes necrospermia?

  • Presence of sperms with multiple tails
  • Presence of dead sperms (correct)
  • Presence of abnormally shaped sperms
  • Presence of motile sperms
  • What happens to primary oocytes at puberty?

  • They complete the first meiotic division
  • They undergo mitosis and produce more primary oocytes
  • They degenerate completely
  • They remain arrested in prophase of the first meiosis (correct)
  • What is the fate of a secondary oocyte if fertilization occurs?

  • It completes the second meiotic division (correct)
  • It degenerates along with the polar body
  • It remains arrested until ovulation
  • It regenerates into a primary oocyte
  • How many secondary oocytes typically develop during a female's reproductive life?

    <p>480</p> Signup and view all the answers

    Which statement is true regarding the size of sperm?

    <p>Giant sperms are significantly larger than typical sperms</p> Signup and view all the answers

    What is the primary role of the acrosome in the mature sperm?

    <p>To assist in penetrating the egg</p> Signup and view all the answers

    During spermatogenesis, how many spermatids are produced from one primary spermatocyte?

    <p>Four</p> Signup and view all the answers

    Which of the following describes the composition of the mature sperm head?

    <p>Contains haploid chromosomes and acrosome</p> Signup and view all the answers

    What is the source of the fluid component of seminal fluid?

    <p>Prostate, seminal vesicle, and bulbourethral glands</p> Signup and view all the answers

    What condition is diagnosed when there is an absence of sperm in the ejaculate?

    <p>Azo-spermia</p> Signup and view all the answers

    Which component of sperm is primarily responsible for providing energy for motility?

    <p>Mitochondrial sheath</p> Signup and view all the answers

    What is the normal range of sperm count in healthy men’s ejaculate?

    <p>200 - 600 million/ml</p> Signup and view all the answers

    What effect does seminal fluid have on vaginal acidity?

    <p>Neutralizes acidity</p> Signup and view all the answers

    What is the main outcome of meiosis in terms of daughter cells?

    <p>Four daughter cells each with half the number of chromosomes as the parent cell</p> Signup and view all the answers

    Which condition is associated with nondisjunction during meiosis?

    <p>Turner syndrome resulting in monosomy</p> Signup and view all the answers

    What is the purpose of gametogenesis?

    <p>To reduce the number of chromosomes from diploid to haploid</p> Signup and view all the answers

    During spermatogenesis, where does the transformation of spermatogonia occur?

    <p>In the seminiferous tubules of the testis</p> Signup and view all the answers

    What is one of the consequences of fertilization involving an abnormal gamete resulting from nondisjunction?

    <p>Creation of an individual with trisomy, such as Down syndrome</p> Signup and view all the answers

    What does mitosis primarily serve in the context of cell division?

    <p>Growth and tissue repair in autosomal cells</p> Signup and view all the answers

    Which of the following statements correctly describes the outcomes of meiosis?

    <p>Generates four genetically different daughter cells</p> Signup and view all the answers

    What is a characteristic feature of mitosis compared to meiosis?

    <p>Produces genetically identical daughter cells</p> Signup and view all the answers

    During oogenesis, after the primary oocytes complete the first meiosis, what is the composition of the resulting secondary oocyte?

    <p>23 chromosomes with 2n DNA</p> Signup and view all the answers

    What is the primary genetic content of the eggs that a female is born with?

    <p>2 million primary oocytes with 4n DNA</p> Signup and view all the answers

    What happens to the secondary oocyte if fertilization does not occur?

    <p>It degenerates along with the polar body.</p> Signup and view all the answers

    What characterizes the major transformation from oogonia to primary oocytes?

    <p>Undergoing mitosis and doubling DNA content</p> Signup and view all the answers

    What is the fate of the first polar body produced during oogenesis?

    <p>It is discarded and does not contribute to fertilization.</p> Signup and view all the answers

    What is the genetic composition of primary spermatocytes after replication?

    <p>46 chromosomes, tetraploid</p> Signup and view all the answers

    Which part of the mature sperm is primarily responsible for motility?

    <p>Principal piece</p> Signup and view all the answers

    What is a defining characteristic of the seminal fluid?

    <p>It contains fructose for sperm nutrition.</p> Signup and view all the answers

    During which phase of sperm development do cytokinesis occur to form spermatids?

    <p>Second meiosis</p> Signup and view all the answers

    What happens during spermiogenesis?

    <p>Physical changes in spermatids to form mature sperm.</p> Signup and view all the answers

    Which of the following abnormalities indicates a low sperm count?

    <p>Oligospermia</p> Signup and view all the answers

    What structure surrounds the anterior two-thirds of the sperm's nucleus?

    <p>Acrosome</p> Signup and view all the answers

    What is the color of normal seminal fluid?

    <p>White</p> Signup and view all the answers

    What is the primary difference in the number of daughter cells produced by meiosis compared to mitosis?

    <p>Meiosis produces four daughter cells.</p> Signup and view all the answers

    Which statement accurately describes a consequence of nondisjunction during meiosis?

    <p>It can lead to conditions such as Turner syndrome.</p> Signup and view all the answers

    What is the primary purpose of spermatogenesis?

    <p>To transform spermatogonia into viable sperm.</p> Signup and view all the answers

    What chromosomal characteristic is present in individuals with Down syndrome?

    <p>46 total chromosomes with an extra chromosome 21.</p> Signup and view all the answers

    In which phase of gametogenesis does the reduction of chromosome number from diploid to haploid occur?

    <p>During meiosis.</p> Signup and view all the answers

    Which type of cell division is responsible for growth or tissue repair?

    <p>Mitosis is used for growth and repair in somatic cells.</p> Signup and view all the answers

    What is one of the outcomes of fertilization involving an abnormal gamete due to nondisjunction?

    <p>It can lead to genetic conditions such as Klinefelter syndrome.</p> Signup and view all the answers

    During which phase does meiosis typically occur in human males?

    <p>Continuously from puberty throughout life.</p> Signup and view all the answers

    Define necrospermia and describe its implications for fertility.

    <p>Necrospermia refers to the presence of dead sperms, which may negatively impact fertility by reducing the likelihood of successful fertilization.</p> Signup and view all the answers

    What are the implications of a female being born with approximately 2 million primary oocytes?

    <p>Having about 2 million primary oocytes indicates a vast potential for ovulation, but by puberty, this number significantly decreases to around 40,000.</p> Signup and view all the answers

    Explain the fate of the first polar body produced during oogenesis.

    <p>The first polar body may either degenerate or, in rare instances, participate in fertilization, but it generally does not contribute to the formation of a viable ovum.</p> Signup and view all the answers

    What role does the second meiosis play in the development of the mature ovum if fertilization occurs?

    <p>If fertilization occurs, the secondary oocyte completes the second meiosis, resulting in a mature ovum and a second polar body.</p> Signup and view all the answers

    Identify a key difference between dwarf and giant sperms and their implications for motility.

    <p>Dwarf sperms are smaller in size, while giant sperms are larger, which may impact their motility and ability to reach and fertilize the egg.</p> Signup and view all the answers

    What is the initial step in spermatogenesis that leads to the formation of primary spermatocytes?

    <p>Spermatogonia undergo mitosis to form daughter spermatogonia.</p> Signup and view all the answers

    Describe the two key processes that spermatids undergo during spermiogenesis.

    <p>Spermatids undergo morphological changes to become mature sperm, including the formation of the acrosome and shedding excess cytoplasm.</p> Signup and view all the answers

    What structures are produced from each secondary spermatocyte after the second meiotic division?

    <p>Each secondary spermatocyte gives rise to two spermatids.</p> Signup and view all the answers

    Identify the two main components that contribute to the formation of seminal fluid.

    <p>Sperms from the testis and fluid from the prostate, seminal vesicle, and bulbourethral glands.</p> Signup and view all the answers

    What is the main difference in the number of daughter cells produced by meiosis and mitosis?

    <p>Meiosis produces 4 daughter cells, while mitosis produces 2 daughter cells.</p> Signup and view all the answers

    What is the role of fructose in seminal fluid?

    <p>Fructose serves as a source of nutrition for sperm.</p> Signup and view all the answers

    In which type of cells does meiosis occur, and what is its primary purpose?

    <p>Meiosis occurs in germ cells, and its primary purpose is for reproduction.</p> Signup and view all the answers

    How does seminal fluid affect the vaginal environment, and why is this important?

    <p>Seminal fluid neutralizes vaginal acidity, creating a more favorable environment for sperm survival and motility.</p> Signup and view all the answers

    What is the recommended sperm count for normal fertility, and what condition is associated with a count lower than this range?

    <p>Normal sperm count ranges from 200 to 600 million; counts lower than 20 million/ml indicate oligospermia.</p> Signup and view all the answers

    What is a consequence of nondisjunction during meiosis?

    <p>Nondisjunction can lead to trisomy or monosomy in the resulting gametes.</p> Signup and view all the answers

    What key transformations occur within the tail of the sperm during spermiogenesis?

    <p>The centriole elongates to form the tail, and mitochondria form a sheath surrounding the proximal part of the tail.</p> Signup and view all the answers

    Describe the site and significance of spermatogenesis.

    <p>Spermatogenesis occurs in the seminiferous tubules of the testes and is significant for the production of sperm.</p> Signup and view all the answers

    What is the role of gametogenesis in sexual reproduction?

    <p>Gametogenesis prepares germ cells for fertilization by reducing the chromosome number from diploid to haploid.</p> Signup and view all the answers

    Identify two conditions that result from abnormal gametes due to nondisjunction.

    <p>Down syndrome and Turner syndrome are two conditions caused by abnormal gametes from nondisjunction.</p> Signup and view all the answers

    What is the significance of halving the chromosome number during meiosis?

    <p>Halving the chromosome number during meiosis is crucial for ensuring genetic stability across generations.</p> Signup and view all the answers

    Explain the difference in chromosome number between daughter cells in mitosis and meiosis.

    <p>Daughter cells produced by mitosis have the same number of chromosomes as the parent cell, while those produced by meiosis have half.</p> Signup and view all the answers

    What is the DNA composition of primary spermatocytes after they undergo mitosis?

    <p>Primary spermatocytes have a diploid DNA composition with 46 chromosomes (4n DNA).</p> Signup and view all the answers

    During spermiogenesis, what major structural change occurs in the tail of the mature sperm?

    <p>The tail elongates as the centriole develops into the tail structure.</p> Signup and view all the answers

    Which components of seminal fluid are critical for sperm motility and nutrition?

    <p>Fructose aids in sperm nutrition and is essential for motility.</p> Signup and view all the answers

    Describe the genetic characteristics of spermatids after the second meiotic division.

    <p>Spermatids are haploid with 23 chromosomes, containing either 22 autosomes plus an X or Y chromosome.</p> Signup and view all the answers

    What is the significance of the Golgi apparatus during spermiogenesis?

    <p>The Golgi apparatus forms the acrosome, which is essential for penetration during fertilization.</p> Signup and view all the answers

    How does the volume and count of sperm per ejaculation vary in healthy males?

    <p>Healthy males produce 200-600 million sperms in a volume of 3-5 cc per ejaculation.</p> Signup and view all the answers

    What are the two types of abnormal sperm counts and their definitions?

    <p>Azoospermia is the absence of sperm, and oligospermia occurs when sperm count is less than 20 million/ml.</p> Signup and view all the answers

    What is the role of the acrosome in a mature sperm cell?

    <p>The acrosome facilitates the sperm's ability to penetrate the egg during fertilization.</p> Signup and view all the answers

    What is the primary genetic outcome of meiosis in terms of chromosome number in daughter cells?

    <p>Daughter cells have half the number of chromosomes compared to the parent cell.</p> Signup and view all the answers

    What is the outcome of fertilization involving an abnormal gamete that has resulted from nondisjunction?

    <p>It can result in conditions such as Down syndrome (trisomy 21) or Turner syndrome (monosomy).</p> Signup and view all the answers

    During spermatogenesis, what is the duration it typically takes from transformation of a spermatogonium to mature sperm?

    <p>The process takes about 2 months.</p> Signup and view all the answers

    In which cell division process does nondisjunction typically occur, leading to chromosomal abnormalities?

    <p>Nondisjunction typically occurs during meiosis.</p> Signup and view all the answers

    What characterizes the difference in the division outcomes between mitosis and meiosis?

    <p>Mitosis results in two identical daughter cells while meiosis produces four genetically diverse daughter cells.</p> Signup and view all the answers

    What sites in the human body are responsible for gametogenesis?

    <p>Gametogenesis occurs in the gonads, which are the testes in males and ovaries in females.</p> Signup and view all the answers

    Describe the term 'trisomy' in relation to chromosomal abnormalities.

    <p>Trisomy refers to an individual having three copies of a particular chromosome instead of the usual two.</p> Signup and view all the answers

    What is the genetic composition of cells produced during the second meiotic division?

    <p>The second meiotic division produces haploid cells, each with one copy of each chromosome.</p> Signup and view all the answers

    What is the significance of the arresting phase of primary oocytes at prophase I until puberty?

    <p>It preserves the genetic material and prepares the oocyte for potential fertilization later in life.</p> Signup and view all the answers

    Discuss the role of polar bodies in oogenesis.

    <p>Polar bodies allow for the conservation of cytoplasm in the developing ovum while reducing chromosome number.</p> Signup and view all the answers

    Compare and contrast the fates of secondary oocytes during fertilization and non-fertilization.

    <p>If fertilized, the secondary oocyte completes meiosis; if not, it degenerates.</p> Signup and view all the answers

    Explain how sperm abnormalities, such as giant or dwarf sperms, affect fertilization success.

    <p>Giant sperms may display impaired motility, while dwarf sperms might lack necessary size for successful penetration of the ovum.</p> Signup and view all the answers

    Why is the number of primary oocytes in females at birth significant for their reproductive lifespan?

    <p>The reduction from about 2 million to 40,000 at puberty indicates a finite ovarian reserve that impacts fertility.</p> Signup and view all the answers

    Explain the significance of the primary oocyte being arrested in prophase until puberty.

    <p>The arrest of primary oocytes in prophase allows them to remain viable for potential fertilization later in life while conserving resources for eventual maturation.</p> Signup and view all the answers

    Discuss the impact of necrospermia on male fertility and potential reproductive outcome.

    <p>Necrospermia, characterized by the presence of dead sperm, significantly reduces fertility potential as it decreases the likelihood of successful fertilization.</p> Signup and view all the answers

    What role does the first polar body play in oogenesis, especially in the context of chromosome distribution?

    <p>The first polar body serves mainly to discard the extra set of chromosomes during the first meiotic division, allowing the secondary oocyte to retain the necessary genetic material.</p> Signup and view all the answers

    Describe how the number of secondary oocytes that develop during a female's reproductive life reflects on evolutionary biology.

    <p>The limited development of around 480 secondary oocytes during a female's reproductive life may reflect an evolutionary strategy to optimize resource allocation and reproductive success.</p> Signup and view all the answers

    Analyze the implications of encountering abnormal sperm shapes, such as giant or dwarf sperm, on fertility.

    <p>Abnormal sperm shapes can hinder motility and the ability to fertilize an egg, potentially leading to decreased fertility or increased difficulty in achieving conception.</p> Signup and view all the answers

    What is the main difference in the number of daughter cells produced by meiosis compared to mitosis?

    <p>Meiosis produces 4 daughter cells, while mitosis produces 2 daughter cells.</p> Signup and view all the answers

    Describe the consequences of nondisjunction during meiosis.

    <p>Nondisjunction can result in gametes with an abnormal number of chromosomes, leading to conditions like trisomy or monosomy.</p> Signup and view all the answers

    What is the purpose of gametogenesis in terms of chromosome number?

    <p>The purpose of gametogenesis is to reduce the chromosome number from diploid to haploid.</p> Signup and view all the answers

    In which cells does spermatogenesis occur and what is its primary outcome?

    <p>Spermatogenesis occurs in the seminiferous tubules of the testis, producing sperm from spermatogonia.</p> Signup and view all the answers

    Explain why older maternal age is a risk factor for nondisjunction during meiosis.

    <p>Advanced maternal age increases the likelihood of errors during meiosis, leading to nondisjunction due to prolonged exposure of oocytes to environmental factors.</p> Signup and view all the answers

    What distinguishes meiosis II from meiosis I in terms of chromosome separation?

    <p>During meiosis I, homologous chromosomes are separated, while meiosis II separates sister chromatids.</p> Signup and view all the answers

    Identify two conditions that result from abnormalities caused by nondisjunction.

    <p>Conditions include Down syndrome (trisomy 21) and Turner syndrome (monosomy X).</p> Signup and view all the answers

    What is the final product of spermatogenesis after two meiotic divisions?

    <p>The final product includes four sperm cells from one primary spermatocyte after two meiotic divisions.</p> Signup and view all the answers

    What is the primary chromosomal composition of a spermatid after the second meiotic division?

    <p>Spermatids have a haploid number of chromosomes, consisting of 23 chromosomes.</p> Signup and view all the answers

    List the main structural components of mature sperm and briefly describe one function of each.

    <p>Mature sperm consists of the head (contains genetic material), neck (houses the centriole), and tail (provides motility).</p> Signup and view all the answers

    What role does the Golgi apparatus play during spermiogenesis?

    <p>The Golgi apparatus forms the acrosome, which covers the anterior two-thirds of the sperm's head.</p> Signup and view all the answers

    Describe the changes that occur to the cytoplasm during spermiogenesis.

    <p>Most of the cytoplasm is shed during spermiogenesis, resulting in a streamlined sperm structure.</p> Signup and view all the answers

    What is the significance of the alkaline reaction of seminal fluid?

    <p>The alkaline reaction of seminal fluid neutralizes vaginal acidity, enhancing sperm survival.</p> Signup and view all the answers

    Identify two factors essential for sperm motility found in seminal fluid.

    <p>Seminal fluid contains fructose for nutrition and has an alkaline reaction for improved sperm survival.</p> Signup and view all the answers

    What are the two conditions related to abnormal sperm counts?

    <p>Azoospermia indicates absent sperm, while oligospermia refers to a sperm count of less than 20 million/ml.</p> Signup and view all the answers

    Explain the process that leads to the formation of secondary spermatocytes from primary spermatocytes.

    <p>Primary spermatocytes undergo the first meiotic division to produce two secondary spermatocytes.</p> Signup and view all the answers

    Study Notes

    Spermatogenesis

    • The process of a spermatogonium transforming into a sperm.
    • Occurs in the seminiferous tubules of the testes.
    • Starts at puberty and continues until old age.
    • Continues for about 2 months.
    • Spermatogonia undergo mitosis to create daughter cells.
    • Daughter cells replicate and differentiate into primary spermatocytes.
    • Primary spermatocytes undergo first meiotic division (meiosis I) to form two secondary spermatocytes.
    • Secondary spermatocytes undergo second meiotic division (meiosis II) to form two spermatids.
    • Spermiogenesis is the final step where spermatids are transformed into mature sperm.
    • The nucleus of the spermatid forms the head of the sperm.
    • The Golgi apparatus surrounds the nucleus to form the acrosome.
    • Mitochondria and centrioles move to the opposite pole.
    • The centriole elongates to form the tail, while the mitochondria forms a sheath around the tail.
    • Most of the cytoplasm is shed.

    Mature Sperm

    • Contains a haploid number of chromosomes (22 + X/Y, n)
    • The anterior 2/3 of the head is covered by the acrosome.
    • The neck contains the centriole.
    • The tail consists of three parts: middle piece, principle piece, and end piece.
    • The middle piece contains the mitochondrial sheath.
    • The principle piece is the longest part and provides motility.

    Seminal Fluid

    • Contains sperm and fluids from the prostate, seminal vesicle, and bulbourethral glands.
    • The fluid is responsible for providing nutrition, promoting sperm motility, and neutralizing vaginal acidity.
    • Consists of 200-600 million sperm.
    • More than 80% of these sperm are motile.
    • The volume of semen is 3-5 cc per ejaculation.
    • The color is white.
    • The odor is semen-specific.
    • The reaction is alkaline.

    Cell Division

    • There are two types of cell division: mitosis and meiosis.

    Mitosis

    • One parent cell divides into two daughter cells.
    • All daughter cells have the same number of chromosomes as the parent cell.
    • All daughter cells have the same amount of DNA as the parent cell.
    • Occurs in autosomal cells for growth and tissue repair.

    Meiosis

    • One parent cell divides into four daughter cells.
    • Each daughter cell has half the number of chromosomes as the parent cell.
    • Each daughter cell has half the amount of DNA present in the parent cell.
    • Occurs in germ cells for reproduction.

    Abnormal Meiosis (Nondisjunction)

    • Nonseparation of a pair of homologous chromosomes during meiosis.
    • May affect autosomes or sex chromosomes.
    • Usually occurs in ova due to advanced maternal age.
    • Can lead to trisomy (47 chromosomes) or monosomy (45 chromosomes).

    Trisomy

    • Down syndrome (trisomy 21).
    • Klinefelter syndrome (44 + XXY).
    • Superfemale syndrome (44 + XXX).

    Monosomy

    • Turner syndrome (44 + XO).

    Gametogenesis

    • The process of forming gametes (sperm or ovum).
    • Occurs in the gonads: the testes and ovaries.
    • Reduces the number of chromosomes from diploid to haploid.
    • It prepares the germ cells for fertilization.

    Oogenesis

    • The process of an oogonium transforming into a mature ovum.
    • Occurs in the cortex of the ovary.
    • Starts during intrauterine life and continues until menopause.

    Oogenesis Before Birth

    • Oogonia undergo mitosis to create daughter cells.
    • Daughter cells replicate and differentiate into primary oocytes.
    • Primary oocytes enter the first meiotic division but stay in prophase until puberty.
    • Females are born with about 2 million primary oocytes in their ovaries.
    • Only 40,000 primary oocytes remain at puberty.

    Oogenesis After Puberty

    • Every month, about 5-15 primary oocytes complete first meiotic division, creating:

      • A secondary oocyte.
      • A first polar body.
    • Both secondary oocytes and the first polar body enter the second meiotic division but remain arrested until fertilization.

    • If fertilization occurs, the secondary oocyte completes the second meiotic division, forming:

      • One mature ovum (23 S. chromosome, 1n DNA).
      • A second polar body.
    • If fertilization does not occur, the secondary oocyte and the first polar body will degenerate.

    • Only about 480 secondary oocytes develop during the woman's reproductive years.

    Spermatocytogenesis

    • Spermatogonia undergo mitosis to form 46 daughter spermatogonia with 2n DNA.
    • Daughter spermatogonia replicate and differentiate into 46 primary spermatocytes with 4n DNA.
    • Primary spermatocytes undergo the first meiotic division to form two secondary spermatocytes with 23 chromosomes and 2n DNA.
    • Secondary spermatocytes undergo the second meiotic division to form two spermatids with 23 chromosomes and 1n DNA.

    Spermiogenesis

    • The nucleus of the spermatid forms the majority of the head.
    • The Golgi apparatus surrounds the anterior 2/3 of the nucleus and forms the acrosome.
    • Mitochondria and centrioles relocate to the opposite pole of the cell.
    • The centriole elongates to form the tail while the mitochondria form a sheath that surrounds the proximal part of the tail.
    • Most of the cytoplasm is shed.
    • After these changes, a mature sperm forms with a head, neck, and tail.
    • The head contains the haploid number of chromosomes (22+ X/Y, n) and is covered by an acrosome on the anterior 2/3.
    • The neck contains a centriole.
    • The tail consists of a middle piece, a principal piece, and an end piece.
    • The middle piece contains a mitochondrial sheath surrounding the proximal part of the tail.
    • The principle piece is the longest portion and is responsible for sperm motility.

    Seminal Fluid

    • Seminal fluid comprises sperm and fluids secreted by the prostate, seminal vesicle, and bulbourethral glands.
    • The average number of sperm per ejaculation is 200-600 million, with more than 80% being motile.
    • The volume of semen per ejaculation is typically 3-5 cc.
    • The fluid is white in color and has a characteristic odor.
    • Seminal fluid has an alkaline pH.
    • Fructose in seminal fluid helps provide nutrition for sperm.
    • Seminal fluid is essential for sperm motility.
    • Seminal fluid helps to neutralize vaginal acidity.

    Abnormal Seminal Fluid

    • Azoospermia is characterized by the absence of sperm in the ejaculate.
    • Oligospermia is a condition where the sperm count is less than 20 million/ml.
    • Necrospermia is characterized by the presence of dead sperm.
    • Some sperm abnormalities are caused by irregular shapes, including giant sperms, dwarf sperms, sperm with 2 heads, and sperm with 2 tails.

    Cell Division

    • Mitosis is a type of cell division that results in two daughter cells, each with the same number of chromosomes as the parent cell.
    • Mitosis occurs in autosomal cells for growth and tissue repair.
    • Meiosis is a type of cell division that results in four daughter cells, each with half the number of chromosomes of the parent cell.
    • Meiosis occurs in germ cells for reproduction.

    Abnormal Meiosis (Nondisjunction)

    • Nondisjunction occurs when a pair of homologous chromosomes fails to separate during meiosis.
    • It can occur in either autosomes or sex chromosomes.
    • Nondisjunction is more common in ova due to advanced maternal age.
    • One cell receives 24 chromosomes, and the other receives 22.
    • Fertilization of an abnormal gamete with a normal gamete of 23 chromosomes can result in an individual with trisomy (47 chromosomes) or monosomy (45 chromosomes).

    Trisomy Examples:

    • Down Syndrome (Trisomy 21)
    • Klinefelter Syndrome (44+XXY)
    • Superfemale Syndrome (44+XXX)

    Monosomy Example:

    • Turner Syndrome (44+XO)

    Gametogenesis

    • Gametogenesis is the process of forming gametes (sperm or ova).
    • Gametogenesis occurs in the gonads (testis and ovary).
    • The aim of gametogenesis is to prepare germ cells for fertilization and reduce the number of chromosomes from diploid to haploid.

    Spermatogenesis

    • Spermatogenesis is the process of transforming a spermatogonium into a mature sperm.
    • This occurs in the seminiferous tubules of the testis.
    • Spermatogenesis begins at puberty and continues throughout a male's lifetime.
    • The process takes about 2 months.

    Oogenesis

    • Oogenesis is the process by which an oogonium transforms into a mature ovum.
    • This occurs in the cortex of the ovary.
    • Oogenesis starts during intrauterine life and ends at menopause.

    Oogenesis Before Birth

    • Oogonia undergo mitosis to form daughter oogonia (46 chromosomes and 2n DNA).
    • Daughter oogonia replicate and differentiate into primary oocytes (46 chromosomes and 4n DNA).
    • Primary oocytes enter the first meiotic division but are arrested in prophase until puberty.
    • At birth, ovaries contain approximately 2 million primary oocytes.
    • Only 40,000 primary oocytes are present at puberty.

    Oogenesis After Puberty

    • Every month, 5–15 primary oocytes complete the first meiotic division, forming one secondary oocyte with 23 chromosomes and 2n DNA, and one polar body.
    • The secondary oocyte and the first polar body enter the second meiotic division and arrest at metaphase until fertilization.
    • If fertilization occurs, the secondary oocyte completes the second meiotic division to form a mature ovum with 23 chromosomes and 1n DNA, and a second polar body.
    • If fertilization does not occur, the secondary oocyte and the first polar body degenerate.
    • Only about 480 secondary oocytes develop during a female's reproductive lifespan.

    Spermatocytogenesis

    • Spermatogonia undergo mitosis to form daughter spermatogonia (46 chromosomes, 2n DNA).
    • Daughter spermatogonia replicate and differentiate into primary spermatocytes (46 chromosomes, 4n DNA).
    • Primary spermatocytes undergo the first meiotic division to produce two secondary spermatocytes (23 chromosomes, 2n DNA).
    • Secondary spermatocytes undergo the second meiotic division to produce two spermatids (23 chromosomes, 1n DNA).

    Spermiogenesis

    • Morphological changes of a spermatid to become a mature sperm.
    • Nucleus forms most of the head.
    • Golgi apparatus surrounds the anterior 2/3 of the nucleus to form the acrosome.
    • Mitochondria and centrioles move to the opposite pole.
    • Centriole elongates to form the tail while the mitochondria forms a sheath that surrounds the proximal part of the tail.
    • Shedding of most of the cytoplasm.

    Mature Sperm

    • Contains a haploid number of chromosomes (22 + X/Y, n).
    • Anterior 2/3 of the head is covered by the acrosome.
    • Neck contains the centriole.
    • Tail consists of:
      • Middle piece: contains the mitochondrial sheath surrounding the proximal part of the tail.
      • Principle piece: longest part that provides sperm motility.
      • End piece.

    Seminal Fluid

    • Contains sperm cells formed in the testis and fluid from the prostate, seminal vesicles and bulbourethral glands.
    • Sperm characteristics:
      • Number: 200-600 million per ejaculation.
      • Motility: more than 80% are motile.
    • Fluid characteristics:
      • Volume: 3-5 cc per ejaculation.
      • Color: White.
      • Odor: Seminiferous odor.
      • Reaction: Alkaline.
    • Function:
      • Contains fructose for sperm nutrition.
      • Essential for sperm motility.
      • Neutralizes vaginal acidity.

    Abnormal Sperm

    • In number:
      • Azoospermia: absence of sperm.
      • Oligospermia: sperm count less than 20 million per ml.
    • In motility:
      • Necrospermia: dead sperm.
    • In shape:
      • Giant sperms: very big sperms.
      • Dwarf sperms: very small sperms.
      • Sperm with two heads.
      • Sperm with two tails.

    Cell Division

    • Meiosis
      • One parent cell divides into four daughter cells.
      • Each daughter cell has half the number of chromosomes of the parent cell.
      • Each daughter cell has half the amount of DNA present in the parent cell.
      • Occurs in germ cells for reproduction.
    • Mitosis
      • One parent cell divides into two daughter cells.
      • All cells have the same number of chromosomes.
      • All cells have the same amount of DNA.
      • Occurs in autosomal cells for growth or tissue repair.

    Abnormal Meiosis (Nondisjunction)

    • Non-separation of a pair of homologous chromosomes during meiosis.
    • May occur in autosomes or sex chromosomes.
    • Usually occurs in ova due to advanced maternal age.
    • One cell receives 24 chromosomes and the other 22 chromosomes.
    • Fertilization of an abnormal gamete with a normal gamete (23 chromosomes) results in:
      • An individual with trisomy (47 chromosomes) e.g.
        • Down syndrome (trisomy 21)
        • Klinefelter syndrome (44 + XXY)
        • Superfemale syndrome (44 + XXX)
      • An individual with monosomy (45 chromosomes) e.g.
        • Turner syndrome (44 + XO).

    Gametogenesis

    • Process of forming gametes (sperm or ovum).
    • Occurs in the gonads (testes and ovaries).
    • Aims to prepare germ cells for fertilization and to reduce the number of chromosomes from diploid to haploid.

    Spermatogenesis

    • Transformation of a spermatogonium into sperm.
    • Occurs in the seminiferous tubules of the testes.
    • Starts at puberty and continues to old age.
    • Duration: about 2 months.

    Oogenesis

    • Process by which an oogonium is transformed into a mature ovum.
    • Occurs in the cortex of the ovary.
    • Starts in intrauterine life and ends at menopause.

    Before Birth

    • Oogonia undergo mitosis to produce daughter oogonia (46 chromosomes, 2n DNA).
    • Daughter oogonia replicate and differentiate into primary oocytes (46 chromosomes, 4n DNA).
    • Primary oocytes enter the first meiotic division but become arrested in prophase until puberty.
    • Ovaries of a female at birth contain about 2 million primary oocytes.
    • Only 40,000 primary oocytes are present at puberty.

    After Puberty

    • Every month, about 5-15 primary oocytes complete the first meiotic division resulting in:
      • One secondary oocyte (23 chromosomes, 2n DNA).
      • One first polar body.
    • The secondary oocyte and first polar body enter the second meiotic division and are arrested at metaphase until fertilization.
    • If fertilization occurs, the secondary oocyte completes the second meiotic division resulting in:
      • One mature ovum (23 chromosomes, 1n DNA).
      • Two polar bodies.
    • If fertilization does not occur, the secondary oocyte and the first polar body degenerate.
    • Only about 480 secondary oocytes develop during the reproductive life of a female.

    Spermatocytogenesis

    • Spermatogonia divide by mitosis to form daughter spermatogonia (46 chromosomes, 2n DNA).
    • Daughter spermatogonia replicate and differentiate into primary spermatocytes (46 chromosomes, 4n DNA).
    • Primary spermatocytes undergo the first meiotic division to produce two secondary spermatocytes (23 chromosomes, 2n DNA).
    • Secondary spermatocytes undergo the second meiotic division to produce two spermatids (23 chromosomes, 1n DNA).

    Spermiogenesis

    • Spermiogenesis refers to the morphological changes a spermatid undergoes to become a mature sperm.
    • The nucleus becomes the main component of the head.
    • The Golgi apparatus surrounds the anterior two-thirds of the nucleus to form the acrosome.
    • The mitochondria and centrioles move to the opposite pole of the cell.
    • The centriole elongates to form the tail, while the mitochondria form a sheath around the proximal part of the tail.
    • Most of the cytoplasm is shed.

    Mature Sperm

    • Mature sperm consists of a head, neck, and tail.
    • The head contains the haploid number of chromosomes (22+X/Y, 1n).
    • The anterior two-thirds of the head are covered by the acrosome.
    • The neck contains a centriole.
    • The tail consists of a middle piece with a mitochondrial sheath, a principle piece that provides motility, and an end piece.

    Seminal Fluid

    • Seminal fluid is composed of sperm produced in the testes and fluid from the prostate, seminal vesicles, and bulbourethral glands.

    Seminal Fluid Properties

    • Sperm: 200-600 million per ejaculation, over 80% are motile.
    • Fluid: 3-5 cc per ejaculation, white color, seminiferous odor, alkaline reaction.

    Seminal Fluid Function

    • Provides fructose for sperm nutrition.
    • Essential for sperm motility.
    • Neutralizes vaginal acidity.

    Abnormal Seminal Fluid

    • Azoospermia: Absence of sperm.
    • Oligospermia: Sperm count less than 20 million/ml.
    • Necrospermia: Dead sperm.
    • Abnormal shapes: Greater than 10% with atypical shapes (giant sperm, dwarf sperm, sperm with two heads, sperm with two tails).

    Cell Division

    • Mitosis
      • One parent cell divides into two daughter cells
      • Daughter cells have the same number of chromosomes as the parent cell
      • Daughter cells have the same amount of DNA as the parent cell
      • Occurs in somatic cells for growth and repair.
    • Meiosis
      • One parent cell divides into four daughter cells
      • Daughter cells have half the number of chromosomes as the parent cell
      • Daughter cells have half the amount of DNA as the parent cell
      • Occurs in germ cells for reproduction

    Abnormal Meiosis (Nondisjunction)

    • Nondisjunction occurs when a pair of homologous chromosomes fails to separate during meiosis.
    • Can occur in autosomes or sex chromosomes.
    • Occurs more frequently in ova due to advanced maternal age.
    • One daughter cell receives 24 chromosomes and the other 22 chromosomes.
    • When an abnormal gamete fertilizes a normal gamete (23 chromosomes), it results in:
      • Trisomy (47 chromosomes) such as Down syndrome (trisomy 21), Klinefelter syndrome (44+XXY), and superfemale syndrome (44+XXX).
      • Monosomy (45 chromosomes) such as Turner syndrome (44+XO).

    Gametogenesis

    • Gametogenesis is the process of forming gametes (sperm or ovum).
    • It occurs in the gonads (testis & ovary).
    • Aim
      • Prepare germ cells for fertilization
      • Reduce the number of chromosomes from diploid to haploid.

    Spermatogenesis

    • The transformation of a spermatogonium into a sperm.
    • Occurs in the seminiferous tubules of the testes.
    • Begins at puberty and continues throughout life.
    • Duration: Approximately 2 months.

    Oogenesis

    • Process by which an oogonium is transformed into a mature ovum.
    • Occurs in the cortex of the ovary.
    • Begins in intrauterine life and continues until menopause.

    Oogenesis Before Birth

    • Oogonia divide by mitosis to form daughter oogonia (46 chromosomes, 2n DNA).
    • Daughter oogonia replicate and differentiate into primary oocytes (46 chromosomes, 4n DNA).
    • Primary oocytes enter the first meiotic division but are arrested in prophase until puberty.
    • At birth, a female's ovaries contain about 2 million primary oocytes.

    Oogenesis At Puberty

    • Only 40,000 primary oocytes are present at puberty.
    • Every month, 5-15 primary oocytes complete the first meiotic division, producing one secondary oocyte (23 chromosomes, 2n DNA) and one first polar body.
    • The secondary oocyte and the first polar body enter the second meiotic division and arrest at metaphase until fertilization.

    Oogenesis After Fertilization

    • If fertilization occurs, the secondary oocyte completes the second meiotic division, producing a mature ovum (23 chromosomes, 1n DNA) and a second polar body.
    • If fertilization does not occur, the secondary oocyte and the first polar body degenerate.

    Oogenesis Note

    • Only about 480 secondary oocytes develop during a woman's reproductive life.

    Spermatocytogenesis

    • Spermatogonia undergo mitosis to produce daughter spermatogonia (46 chromosomes, 2n DNA)
    • Daughter spermatogonia replicate and differentiate into primary spermatocytes (46 chromosomes, 4n DNA)
    • Primary spermatocytes undergo the first meiotic division to produce two secondary spermatocytes (23 chromosomes, 2n DNA)
    • Secondary spermatocytes undergo the second meiotic division to produce two spermatids (23 chromosomes, 1n DNA)

    Spermiogenesis

    • Spermiogenesis is the morphological transformation of a spermatid into a mature sperm.
    • The nucleus forms most of the head.
    • The Golgi apparatus surrounds the anterior two-thirds of the nucleus to form the acrosome.
    • The mitochondria and two centrioles move to the opposite pole.
    • The centriole elongates to form the tail while the mitochondria forms a sheath that surrounds the proximal part of the tail.
    • Most of the cytoplasm is shed.

    Mature Sperm Components

    • Head: Contains the haploid number of chromosomes (22 + X/Y, n).
    • Head: The anterior two-thirds are covered by the acrosome.
    • Neck: Contains the centriole.
    • Tail:
      • Middle piece: Contains the mitochondrial sheath surrounding the proximal part of the tail.
      • Principal piece: The longest part that provides sperm motility.
      • End piece:

    Seminal Fluid

    • Source:

      • Sperms: Formated in the testis.
      • Fluid: From the prostate, seminal vesicle, and bulbourethral glands.
    • Characters:

      • Sperms:
        • Number: 200–600 million
        • Motility: More than 80% are motile.
      • Fluid:
        • Volume: 3-5 cc per ejaculation
        • Color: White
        • Odor: Seminiferous odor
        • Reaction: Alkaline
    • Function:

      • Contains fructose for sperm nutrition.
      • Essential for sperm motility.
      • Neutralizes vaginal acidity.

    Abnormal Seminal Fluid

    • In number:
      • Azoospermia: Absent sperms.
      • Oligospermia: Sperm count less than 20 million per ml.
    • In motility:
      • Necrospermia: Dead sperms.
    • In shape:
      • Normally less than 10% are abnormal.
      • Giant sperms: Very big sperms.
      • Dwarf sperms: Very small sperms.
      • Sperm with 2 heads.
      • Sperm with 2 tails.

    Cell Division

    • Mitosis:
      • One parent cell divides into two daughter cells.
      • All cells have the same number of chromosomes.
      • All cells have the same amount of DNA.
      • Occurs in autosomal cells for growth or tissue repair.
    • Meiosis:
      • One parent cell divides into four daughter cells.
      • Each daughter cell has half the number of chromosomes in the parent cell.
      • Each daughter cell has half the amount of DNA present in the parent cell.
      • Occurs in germ cells for reproduction.

    Abnormal Meiosis (Nondisjunction)

    • Non-separation of a pair of homologous chromosomes during meiosis.
    • May occur in the autosomes or sex chromosomes.
    • Usually occurs in the ova due to advanced maternal age.
    • One cell receives 24 chromosomes and the other receives 22 chromosomes.

    Fertilization of Abnormal Gametes

    • Fertilization of an abnormal gamete (24 or 22 chromosomes) with a normal gamete (23 chromosomes) results in:
      • An individual of trisomy (47 chromosomes), e.g.:

        • Down syndrome (trisomy 21)
        • Klinefelter syndrome (44+XXY)
        • Superfemale syndrome (44+XXX)
      • An individual of monosomy (45 chromosomes), e.g.:

        • Turner syndrome (44+XO)

    Gametogenesis

    • The process of formation of gametes (sperm or ovum)
    • Site: Gonads (testis and ovary)
    • Aim:
      • Preparation of germ cells for fertilization.
      • Reduction of the number of chromosomes from diploid to haploid.

    Spermatogenesis

    • The transformation of a spermatogonium into sperm.
    • Site: Seminiferous tubules of the testis.
    • Time: From puberty and continues until old age.
    • Duration: About 2 months

    Oogenesis

    • Process by which an oogonium is transformed into a mature ovum.
    • Site: Cortex of the ovary.
    • Time: From intrauterine life to menopause.

    Oogenesis: Before Birth

    • Oogonia undergo mitosis giving daughter oogonia (46 chromosomes, 2n DNA).
    • Daughter oogonia replicate and differentiate into primary oocytes (46 chromosomes, 4n DNA).
    • Primary oocytes enter the first meiotic division but become arrested in prophase until puberty.
    • The female is born with ovaries containing about 2 million primary oocytes.
    • Only 40,000 primary oocytes are present at puberty.

    Oogenesis: After Puberty

    • Every month, about 5-15 primary oocytes complete the first meiotic division giving:
      • One secondary oocyte (23 chromosomes, 2n DNA)
      • One first polar body.
    • Both the secondary oocyte and the first polar body enter the second meiotic division and are arrested at metaphase until fertilization.
    • If fertilization occurs, the secondary oocyte completes the second meiotic division, giving a mature ovum (23 chromosomes, 1n DNA) and a second polar body.
    • If fertilization does not occur, both the secondary oocyte and the first polar body degenerate.
    • Only about 480 secondary oocytes develop during the reproductive life of the female.

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