Podcast
Questions and Answers
What characterizes necrospermia?
What characterizes necrospermia?
What happens to primary oocytes at puberty?
What happens to primary oocytes at puberty?
What is the fate of a secondary oocyte if fertilization occurs?
What is the fate of a secondary oocyte if fertilization occurs?
How many secondary oocytes typically develop during a female's reproductive life?
How many secondary oocytes typically develop during a female's reproductive life?
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Which statement is true regarding the size of sperm?
Which statement is true regarding the size of sperm?
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What is the primary role of the acrosome in the mature sperm?
What is the primary role of the acrosome in the mature sperm?
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During spermatogenesis, how many spermatids are produced from one primary spermatocyte?
During spermatogenesis, how many spermatids are produced from one primary spermatocyte?
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Which of the following describes the composition of the mature sperm head?
Which of the following describes the composition of the mature sperm head?
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What is the source of the fluid component of seminal fluid?
What is the source of the fluid component of seminal fluid?
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What condition is diagnosed when there is an absence of sperm in the ejaculate?
What condition is diagnosed when there is an absence of sperm in the ejaculate?
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Which component of sperm is primarily responsible for providing energy for motility?
Which component of sperm is primarily responsible for providing energy for motility?
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What is the normal range of sperm count in healthy men’s ejaculate?
What is the normal range of sperm count in healthy men’s ejaculate?
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What effect does seminal fluid have on vaginal acidity?
What effect does seminal fluid have on vaginal acidity?
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What is the main outcome of meiosis in terms of daughter cells?
What is the main outcome of meiosis in terms of daughter cells?
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Which condition is associated with nondisjunction during meiosis?
Which condition is associated with nondisjunction during meiosis?
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What is the purpose of gametogenesis?
What is the purpose of gametogenesis?
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During spermatogenesis, where does the transformation of spermatogonia occur?
During spermatogenesis, where does the transformation of spermatogonia occur?
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What is one of the consequences of fertilization involving an abnormal gamete resulting from nondisjunction?
What is one of the consequences of fertilization involving an abnormal gamete resulting from nondisjunction?
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What does mitosis primarily serve in the context of cell division?
What does mitosis primarily serve in the context of cell division?
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Which of the following statements correctly describes the outcomes of meiosis?
Which of the following statements correctly describes the outcomes of meiosis?
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What is a characteristic feature of mitosis compared to meiosis?
What is a characteristic feature of mitosis compared to meiosis?
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During oogenesis, after the primary oocytes complete the first meiosis, what is the composition of the resulting secondary oocyte?
During oogenesis, after the primary oocytes complete the first meiosis, what is the composition of the resulting secondary oocyte?
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What is the primary genetic content of the eggs that a female is born with?
What is the primary genetic content of the eggs that a female is born with?
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What happens to the secondary oocyte if fertilization does not occur?
What happens to the secondary oocyte if fertilization does not occur?
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What characterizes the major transformation from oogonia to primary oocytes?
What characterizes the major transformation from oogonia to primary oocytes?
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What is the fate of the first polar body produced during oogenesis?
What is the fate of the first polar body produced during oogenesis?
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What is the genetic composition of primary spermatocytes after replication?
What is the genetic composition of primary spermatocytes after replication?
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Which part of the mature sperm is primarily responsible for motility?
Which part of the mature sperm is primarily responsible for motility?
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What is a defining characteristic of the seminal fluid?
What is a defining characteristic of the seminal fluid?
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During which phase of sperm development do cytokinesis occur to form spermatids?
During which phase of sperm development do cytokinesis occur to form spermatids?
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What happens during spermiogenesis?
What happens during spermiogenesis?
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Which of the following abnormalities indicates a low sperm count?
Which of the following abnormalities indicates a low sperm count?
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What structure surrounds the anterior two-thirds of the sperm's nucleus?
What structure surrounds the anterior two-thirds of the sperm's nucleus?
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What is the color of normal seminal fluid?
What is the color of normal seminal fluid?
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What is the primary difference in the number of daughter cells produced by meiosis compared to mitosis?
What is the primary difference in the number of daughter cells produced by meiosis compared to mitosis?
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Which statement accurately describes a consequence of nondisjunction during meiosis?
Which statement accurately describes a consequence of nondisjunction during meiosis?
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What is the primary purpose of spermatogenesis?
What is the primary purpose of spermatogenesis?
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What chromosomal characteristic is present in individuals with Down syndrome?
What chromosomal characteristic is present in individuals with Down syndrome?
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In which phase of gametogenesis does the reduction of chromosome number from diploid to haploid occur?
In which phase of gametogenesis does the reduction of chromosome number from diploid to haploid occur?
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Which type of cell division is responsible for growth or tissue repair?
Which type of cell division is responsible for growth or tissue repair?
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What is one of the outcomes of fertilization involving an abnormal gamete due to nondisjunction?
What is one of the outcomes of fertilization involving an abnormal gamete due to nondisjunction?
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During which phase does meiosis typically occur in human males?
During which phase does meiosis typically occur in human males?
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Define necrospermia and describe its implications for fertility.
Define necrospermia and describe its implications for fertility.
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What are the implications of a female being born with approximately 2 million primary oocytes?
What are the implications of a female being born with approximately 2 million primary oocytes?
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Explain the fate of the first polar body produced during oogenesis.
Explain the fate of the first polar body produced during oogenesis.
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What role does the second meiosis play in the development of the mature ovum if fertilization occurs?
What role does the second meiosis play in the development of the mature ovum if fertilization occurs?
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Identify a key difference between dwarf and giant sperms and their implications for motility.
Identify a key difference between dwarf and giant sperms and their implications for motility.
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What is the initial step in spermatogenesis that leads to the formation of primary spermatocytes?
What is the initial step in spermatogenesis that leads to the formation of primary spermatocytes?
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Describe the two key processes that spermatids undergo during spermiogenesis.
Describe the two key processes that spermatids undergo during spermiogenesis.
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What structures are produced from each secondary spermatocyte after the second meiotic division?
What structures are produced from each secondary spermatocyte after the second meiotic division?
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Identify the two main components that contribute to the formation of seminal fluid.
Identify the two main components that contribute to the formation of seminal fluid.
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What is the main difference in the number of daughter cells produced by meiosis and mitosis?
What is the main difference in the number of daughter cells produced by meiosis and mitosis?
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What is the role of fructose in seminal fluid?
What is the role of fructose in seminal fluid?
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In which type of cells does meiosis occur, and what is its primary purpose?
In which type of cells does meiosis occur, and what is its primary purpose?
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How does seminal fluid affect the vaginal environment, and why is this important?
How does seminal fluid affect the vaginal environment, and why is this important?
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What is the recommended sperm count for normal fertility, and what condition is associated with a count lower than this range?
What is the recommended sperm count for normal fertility, and what condition is associated with a count lower than this range?
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What is a consequence of nondisjunction during meiosis?
What is a consequence of nondisjunction during meiosis?
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What key transformations occur within the tail of the sperm during spermiogenesis?
What key transformations occur within the tail of the sperm during spermiogenesis?
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Describe the site and significance of spermatogenesis.
Describe the site and significance of spermatogenesis.
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What is the role of gametogenesis in sexual reproduction?
What is the role of gametogenesis in sexual reproduction?
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Identify two conditions that result from abnormal gametes due to nondisjunction.
Identify two conditions that result from abnormal gametes due to nondisjunction.
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What is the significance of halving the chromosome number during meiosis?
What is the significance of halving the chromosome number during meiosis?
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Explain the difference in chromosome number between daughter cells in mitosis and meiosis.
Explain the difference in chromosome number between daughter cells in mitosis and meiosis.
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What is the DNA composition of primary spermatocytes after they undergo mitosis?
What is the DNA composition of primary spermatocytes after they undergo mitosis?
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During spermiogenesis, what major structural change occurs in the tail of the mature sperm?
During spermiogenesis, what major structural change occurs in the tail of the mature sperm?
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Which components of seminal fluid are critical for sperm motility and nutrition?
Which components of seminal fluid are critical for sperm motility and nutrition?
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Describe the genetic characteristics of spermatids after the second meiotic division.
Describe the genetic characteristics of spermatids after the second meiotic division.
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What is the significance of the Golgi apparatus during spermiogenesis?
What is the significance of the Golgi apparatus during spermiogenesis?
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How does the volume and count of sperm per ejaculation vary in healthy males?
How does the volume and count of sperm per ejaculation vary in healthy males?
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What are the two types of abnormal sperm counts and their definitions?
What are the two types of abnormal sperm counts and their definitions?
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What is the role of the acrosome in a mature sperm cell?
What is the role of the acrosome in a mature sperm cell?
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What is the primary genetic outcome of meiosis in terms of chromosome number in daughter cells?
What is the primary genetic outcome of meiosis in terms of chromosome number in daughter cells?
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What is the outcome of fertilization involving an abnormal gamete that has resulted from nondisjunction?
What is the outcome of fertilization involving an abnormal gamete that has resulted from nondisjunction?
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During spermatogenesis, what is the duration it typically takes from transformation of a spermatogonium to mature sperm?
During spermatogenesis, what is the duration it typically takes from transformation of a spermatogonium to mature sperm?
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In which cell division process does nondisjunction typically occur, leading to chromosomal abnormalities?
In which cell division process does nondisjunction typically occur, leading to chromosomal abnormalities?
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What characterizes the difference in the division outcomes between mitosis and meiosis?
What characterizes the difference in the division outcomes between mitosis and meiosis?
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What sites in the human body are responsible for gametogenesis?
What sites in the human body are responsible for gametogenesis?
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Describe the term 'trisomy' in relation to chromosomal abnormalities.
Describe the term 'trisomy' in relation to chromosomal abnormalities.
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What is the genetic composition of cells produced during the second meiotic division?
What is the genetic composition of cells produced during the second meiotic division?
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What is the significance of the arresting phase of primary oocytes at prophase I until puberty?
What is the significance of the arresting phase of primary oocytes at prophase I until puberty?
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Discuss the role of polar bodies in oogenesis.
Discuss the role of polar bodies in oogenesis.
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Compare and contrast the fates of secondary oocytes during fertilization and non-fertilization.
Compare and contrast the fates of secondary oocytes during fertilization and non-fertilization.
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Explain how sperm abnormalities, such as giant or dwarf sperms, affect fertilization success.
Explain how sperm abnormalities, such as giant or dwarf sperms, affect fertilization success.
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Why is the number of primary oocytes in females at birth significant for their reproductive lifespan?
Why is the number of primary oocytes in females at birth significant for their reproductive lifespan?
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Explain the significance of the primary oocyte being arrested in prophase until puberty.
Explain the significance of the primary oocyte being arrested in prophase until puberty.
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Discuss the impact of necrospermia on male fertility and potential reproductive outcome.
Discuss the impact of necrospermia on male fertility and potential reproductive outcome.
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What role does the first polar body play in oogenesis, especially in the context of chromosome distribution?
What role does the first polar body play in oogenesis, especially in the context of chromosome distribution?
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Describe how the number of secondary oocytes that develop during a female's reproductive life reflects on evolutionary biology.
Describe how the number of secondary oocytes that develop during a female's reproductive life reflects on evolutionary biology.
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Analyze the implications of encountering abnormal sperm shapes, such as giant or dwarf sperm, on fertility.
Analyze the implications of encountering abnormal sperm shapes, such as giant or dwarf sperm, on fertility.
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What is the main difference in the number of daughter cells produced by meiosis compared to mitosis?
What is the main difference in the number of daughter cells produced by meiosis compared to mitosis?
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Describe the consequences of nondisjunction during meiosis.
Describe the consequences of nondisjunction during meiosis.
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What is the purpose of gametogenesis in terms of chromosome number?
What is the purpose of gametogenesis in terms of chromosome number?
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In which cells does spermatogenesis occur and what is its primary outcome?
In which cells does spermatogenesis occur and what is its primary outcome?
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Explain why older maternal age is a risk factor for nondisjunction during meiosis.
Explain why older maternal age is a risk factor for nondisjunction during meiosis.
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What distinguishes meiosis II from meiosis I in terms of chromosome separation?
What distinguishes meiosis II from meiosis I in terms of chromosome separation?
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Identify two conditions that result from abnormalities caused by nondisjunction.
Identify two conditions that result from abnormalities caused by nondisjunction.
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What is the final product of spermatogenesis after two meiotic divisions?
What is the final product of spermatogenesis after two meiotic divisions?
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What is the primary chromosomal composition of a spermatid after the second meiotic division?
What is the primary chromosomal composition of a spermatid after the second meiotic division?
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List the main structural components of mature sperm and briefly describe one function of each.
List the main structural components of mature sperm and briefly describe one function of each.
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What role does the Golgi apparatus play during spermiogenesis?
What role does the Golgi apparatus play during spermiogenesis?
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Describe the changes that occur to the cytoplasm during spermiogenesis.
Describe the changes that occur to the cytoplasm during spermiogenesis.
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What is the significance of the alkaline reaction of seminal fluid?
What is the significance of the alkaline reaction of seminal fluid?
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Identify two factors essential for sperm motility found in seminal fluid.
Identify two factors essential for sperm motility found in seminal fluid.
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What are the two conditions related to abnormal sperm counts?
What are the two conditions related to abnormal sperm counts?
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Explain the process that leads to the formation of secondary spermatocytes from primary spermatocytes.
Explain the process that leads to the formation of secondary spermatocytes from primary spermatocytes.
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Study Notes
Spermatogenesis
- The process of a spermatogonium transforming into a sperm.
- Occurs in the seminiferous tubules of the testes.
- Starts at puberty and continues until old age.
- Continues for about 2 months.
- Spermatogonia undergo mitosis to create daughter cells.
- Daughter cells replicate and differentiate into primary spermatocytes.
- Primary spermatocytes undergo first meiotic division (meiosis I) to form two secondary spermatocytes.
- Secondary spermatocytes undergo second meiotic division (meiosis II) to form two spermatids.
- Spermiogenesis is the final step where spermatids are transformed into mature sperm.
- The nucleus of the spermatid forms the head of the sperm.
- The Golgi apparatus surrounds the nucleus to form the acrosome.
- Mitochondria and centrioles move to the opposite pole.
- The centriole elongates to form the tail, while the mitochondria forms a sheath around the tail.
- Most of the cytoplasm is shed.
Mature Sperm
- Contains a haploid number of chromosomes (22 + X/Y, n)
- The anterior 2/3 of the head is covered by the acrosome.
- The neck contains the centriole.
- The tail consists of three parts: middle piece, principle piece, and end piece.
- The middle piece contains the mitochondrial sheath.
- The principle piece is the longest part and provides motility.
Seminal Fluid
- Contains sperm and fluids from the prostate, seminal vesicle, and bulbourethral glands.
- The fluid is responsible for providing nutrition, promoting sperm motility, and neutralizing vaginal acidity.
- Consists of 200-600 million sperm.
- More than 80% of these sperm are motile.
- The volume of semen is 3-5 cc per ejaculation.
- The color is white.
- The odor is semen-specific.
- The reaction is alkaline.
Cell Division
- There are two types of cell division: mitosis and meiosis.
Mitosis
- One parent cell divides into two daughter cells.
- All daughter cells have the same number of chromosomes as the parent cell.
- All daughter cells have the same amount of DNA as the parent cell.
- Occurs in autosomal cells for growth and tissue repair.
Meiosis
- One parent cell divides into four daughter cells.
- Each daughter cell has half the number of chromosomes as the parent cell.
- Each daughter cell has half the amount of DNA present in the parent cell.
- Occurs in germ cells for reproduction.
Abnormal Meiosis (Nondisjunction)
- Nonseparation of a pair of homologous chromosomes during meiosis.
- May affect autosomes or sex chromosomes.
- Usually occurs in ova due to advanced maternal age.
- Can lead to trisomy (47 chromosomes) or monosomy (45 chromosomes).
Trisomy
- Down syndrome (trisomy 21).
- Klinefelter syndrome (44 + XXY).
- Superfemale syndrome (44 + XXX).
Monosomy
- Turner syndrome (44 + XO).
Gametogenesis
- The process of forming gametes (sperm or ovum).
- Occurs in the gonads: the testes and ovaries.
- Reduces the number of chromosomes from diploid to haploid.
- It prepares the germ cells for fertilization.
Oogenesis
- The process of an oogonium transforming into a mature ovum.
- Occurs in the cortex of the ovary.
- Starts during intrauterine life and continues until menopause.
Oogenesis Before Birth
- Oogonia undergo mitosis to create daughter cells.
- Daughter cells replicate and differentiate into primary oocytes.
- Primary oocytes enter the first meiotic division but stay in prophase until puberty.
- Females are born with about 2 million primary oocytes in their ovaries.
- Only 40,000 primary oocytes remain at puberty.
Oogenesis After Puberty
-
Every month, about 5-15 primary oocytes complete first meiotic division, creating:
- A secondary oocyte.
- A first polar body.
-
Both secondary oocytes and the first polar body enter the second meiotic division but remain arrested until fertilization.
-
If fertilization occurs, the secondary oocyte completes the second meiotic division, forming:
- One mature ovum (23 S. chromosome, 1n DNA).
- A second polar body.
-
If fertilization does not occur, the secondary oocyte and the first polar body will degenerate.
-
Only about 480 secondary oocytes develop during the woman's reproductive years.
Spermatocytogenesis
- Spermatogonia undergo mitosis to form 46 daughter spermatogonia with 2n DNA.
- Daughter spermatogonia replicate and differentiate into 46 primary spermatocytes with 4n DNA.
- Primary spermatocytes undergo the first meiotic division to form two secondary spermatocytes with 23 chromosomes and 2n DNA.
- Secondary spermatocytes undergo the second meiotic division to form two spermatids with 23 chromosomes and 1n DNA.
Spermiogenesis
- The nucleus of the spermatid forms the majority of the head.
- The Golgi apparatus surrounds the anterior 2/3 of the nucleus and forms the acrosome.
- Mitochondria and centrioles relocate to the opposite pole of the cell.
- The centriole elongates to form the tail while the mitochondria form a sheath that surrounds the proximal part of the tail.
- Most of the cytoplasm is shed.
- After these changes, a mature sperm forms with a head, neck, and tail.
- The head contains the haploid number of chromosomes (22+ X/Y, n) and is covered by an acrosome on the anterior 2/3.
- The neck contains a centriole.
- The tail consists of a middle piece, a principal piece, and an end piece.
- The middle piece contains a mitochondrial sheath surrounding the proximal part of the tail.
- The principle piece is the longest portion and is responsible for sperm motility.
Seminal Fluid
- Seminal fluid comprises sperm and fluids secreted by the prostate, seminal vesicle, and bulbourethral glands.
- The average number of sperm per ejaculation is 200-600 million, with more than 80% being motile.
- The volume of semen per ejaculation is typically 3-5 cc.
- The fluid is white in color and has a characteristic odor.
- Seminal fluid has an alkaline pH.
- Fructose in seminal fluid helps provide nutrition for sperm.
- Seminal fluid is essential for sperm motility.
- Seminal fluid helps to neutralize vaginal acidity.
Abnormal Seminal Fluid
- Azoospermia is characterized by the absence of sperm in the ejaculate.
- Oligospermia is a condition where the sperm count is less than 20 million/ml.
- Necrospermia is characterized by the presence of dead sperm.
- Some sperm abnormalities are caused by irregular shapes, including giant sperms, dwarf sperms, sperm with 2 heads, and sperm with 2 tails.
Cell Division
- Mitosis is a type of cell division that results in two daughter cells, each with the same number of chromosomes as the parent cell.
- Mitosis occurs in autosomal cells for growth and tissue repair.
- Meiosis is a type of cell division that results in four daughter cells, each with half the number of chromosomes of the parent cell.
- Meiosis occurs in germ cells for reproduction.
Abnormal Meiosis (Nondisjunction)
- Nondisjunction occurs when a pair of homologous chromosomes fails to separate during meiosis.
- It can occur in either autosomes or sex chromosomes.
- Nondisjunction is more common in ova due to advanced maternal age.
- One cell receives 24 chromosomes, and the other receives 22.
- Fertilization of an abnormal gamete with a normal gamete of 23 chromosomes can result in an individual with trisomy (47 chromosomes) or monosomy (45 chromosomes).
Trisomy Examples:
- Down Syndrome (Trisomy 21)
- Klinefelter Syndrome (44+XXY)
- Superfemale Syndrome (44+XXX)
Monosomy Example:
- Turner Syndrome (44+XO)
Gametogenesis
- Gametogenesis is the process of forming gametes (sperm or ova).
- Gametogenesis occurs in the gonads (testis and ovary).
- The aim of gametogenesis is to prepare germ cells for fertilization and reduce the number of chromosomes from diploid to haploid.
Spermatogenesis
- Spermatogenesis is the process of transforming a spermatogonium into a mature sperm.
- This occurs in the seminiferous tubules of the testis.
- Spermatogenesis begins at puberty and continues throughout a male's lifetime.
- The process takes about 2 months.
Oogenesis
- Oogenesis is the process by which an oogonium transforms into a mature ovum.
- This occurs in the cortex of the ovary.
- Oogenesis starts during intrauterine life and ends at menopause.
Oogenesis Before Birth
- Oogonia undergo mitosis to form daughter oogonia (46 chromosomes and 2n DNA).
- Daughter oogonia replicate and differentiate into primary oocytes (46 chromosomes and 4n DNA).
- Primary oocytes enter the first meiotic division but are arrested in prophase until puberty.
- At birth, ovaries contain approximately 2 million primary oocytes.
- Only 40,000 primary oocytes are present at puberty.
Oogenesis After Puberty
- Every month, 5–15 primary oocytes complete the first meiotic division, forming one secondary oocyte with 23 chromosomes and 2n DNA, and one polar body.
- The secondary oocyte and the first polar body enter the second meiotic division and arrest at metaphase until fertilization.
- If fertilization occurs, the secondary oocyte completes the second meiotic division to form a mature ovum with 23 chromosomes and 1n DNA, and a second polar body.
- If fertilization does not occur, the secondary oocyte and the first polar body degenerate.
- Only about 480 secondary oocytes develop during a female's reproductive lifespan.
Spermatocytogenesis
- Spermatogonia undergo mitosis to form daughter spermatogonia (46 chromosomes, 2n DNA).
- Daughter spermatogonia replicate and differentiate into primary spermatocytes (46 chromosomes, 4n DNA).
- Primary spermatocytes undergo the first meiotic division to produce two secondary spermatocytes (23 chromosomes, 2n DNA).
- Secondary spermatocytes undergo the second meiotic division to produce two spermatids (23 chromosomes, 1n DNA).
Spermiogenesis
- Morphological changes of a spermatid to become a mature sperm.
- Nucleus forms most of the head.
- Golgi apparatus surrounds the anterior 2/3 of the nucleus to form the acrosome.
- Mitochondria and centrioles move to the opposite pole.
- Centriole elongates to form the tail while the mitochondria forms a sheath that surrounds the proximal part of the tail.
- Shedding of most of the cytoplasm.
Mature Sperm
- Contains a haploid number of chromosomes (22 + X/Y, n).
- Anterior 2/3 of the head is covered by the acrosome.
- Neck contains the centriole.
- Tail consists of:
- Middle piece: contains the mitochondrial sheath surrounding the proximal part of the tail.
- Principle piece: longest part that provides sperm motility.
- End piece.
Seminal Fluid
- Contains sperm cells formed in the testis and fluid from the prostate, seminal vesicles and bulbourethral glands.
- Sperm characteristics:
- Number: 200-600 million per ejaculation.
- Motility: more than 80% are motile.
- Fluid characteristics:
- Volume: 3-5 cc per ejaculation.
- Color: White.
- Odor: Seminiferous odor.
- Reaction: Alkaline.
- Function:
- Contains fructose for sperm nutrition.
- Essential for sperm motility.
- Neutralizes vaginal acidity.
Abnormal Sperm
- In number:
- Azoospermia: absence of sperm.
- Oligospermia: sperm count less than 20 million per ml.
- In motility:
- Necrospermia: dead sperm.
- In shape:
- Giant sperms: very big sperms.
- Dwarf sperms: very small sperms.
- Sperm with two heads.
- Sperm with two tails.
Cell Division
-
Meiosis
- One parent cell divides into four daughter cells.
- Each daughter cell has half the number of chromosomes of the parent cell.
- Each daughter cell has half the amount of DNA present in the parent cell.
- Occurs in germ cells for reproduction.
-
Mitosis
- One parent cell divides into two daughter cells.
- All cells have the same number of chromosomes.
- All cells have the same amount of DNA.
- Occurs in autosomal cells for growth or tissue repair.
Abnormal Meiosis (Nondisjunction)
- Non-separation of a pair of homologous chromosomes during meiosis.
- May occur in autosomes or sex chromosomes.
- Usually occurs in ova due to advanced maternal age.
- One cell receives 24 chromosomes and the other 22 chromosomes.
- Fertilization of an abnormal gamete with a normal gamete (23 chromosomes) results in:
- An individual with trisomy (47 chromosomes) e.g.
- Down syndrome (trisomy 21)
- Klinefelter syndrome (44 + XXY)
- Superfemale syndrome (44 + XXX)
- An individual with monosomy (45 chromosomes) e.g.
- Turner syndrome (44 + XO).
- An individual with trisomy (47 chromosomes) e.g.
Gametogenesis
- Process of forming gametes (sperm or ovum).
- Occurs in the gonads (testes and ovaries).
- Aims to prepare germ cells for fertilization and to reduce the number of chromosomes from diploid to haploid.
Spermatogenesis
- Transformation of a spermatogonium into sperm.
- Occurs in the seminiferous tubules of the testes.
- Starts at puberty and continues to old age.
- Duration: about 2 months.
Oogenesis
- Process by which an oogonium is transformed into a mature ovum.
- Occurs in the cortex of the ovary.
- Starts in intrauterine life and ends at menopause.
Before Birth
- Oogonia undergo mitosis to produce daughter oogonia (46 chromosomes, 2n DNA).
- Daughter oogonia replicate and differentiate into primary oocytes (46 chromosomes, 4n DNA).
- Primary oocytes enter the first meiotic division but become arrested in prophase until puberty.
- Ovaries of a female at birth contain about 2 million primary oocytes.
- Only 40,000 primary oocytes are present at puberty.
After Puberty
- Every month, about 5-15 primary oocytes complete the first meiotic division resulting in:
- One secondary oocyte (23 chromosomes, 2n DNA).
- One first polar body.
- The secondary oocyte and first polar body enter the second meiotic division and are arrested at metaphase until fertilization.
- If fertilization occurs, the secondary oocyte completes the second meiotic division resulting in:
- One mature ovum (23 chromosomes, 1n DNA).
- Two polar bodies.
- If fertilization does not occur, the secondary oocyte and the first polar body degenerate.
- Only about 480 secondary oocytes develop during the reproductive life of a female.
Spermatocytogenesis
- Spermatogonia divide by mitosis to form daughter spermatogonia (46 chromosomes, 2n DNA).
- Daughter spermatogonia replicate and differentiate into primary spermatocytes (46 chromosomes, 4n DNA).
- Primary spermatocytes undergo the first meiotic division to produce two secondary spermatocytes (23 chromosomes, 2n DNA).
- Secondary spermatocytes undergo the second meiotic division to produce two spermatids (23 chromosomes, 1n DNA).
Spermiogenesis
- Spermiogenesis refers to the morphological changes a spermatid undergoes to become a mature sperm.
- The nucleus becomes the main component of the head.
- The Golgi apparatus surrounds the anterior two-thirds of the nucleus to form the acrosome.
- The mitochondria and centrioles move to the opposite pole of the cell.
- The centriole elongates to form the tail, while the mitochondria form a sheath around the proximal part of the tail.
- Most of the cytoplasm is shed.
Mature Sperm
- Mature sperm consists of a head, neck, and tail.
- The head contains the haploid number of chromosomes (22+X/Y, 1n).
- The anterior two-thirds of the head are covered by the acrosome.
- The neck contains a centriole.
- The tail consists of a middle piece with a mitochondrial sheath, a principle piece that provides motility, and an end piece.
Seminal Fluid
- Seminal fluid is composed of sperm produced in the testes and fluid from the prostate, seminal vesicles, and bulbourethral glands.
Seminal Fluid Properties
- Sperm: 200-600 million per ejaculation, over 80% are motile.
- Fluid: 3-5 cc per ejaculation, white color, seminiferous odor, alkaline reaction.
Seminal Fluid Function
- Provides fructose for sperm nutrition.
- Essential for sperm motility.
- Neutralizes vaginal acidity.
Abnormal Seminal Fluid
- Azoospermia: Absence of sperm.
- Oligospermia: Sperm count less than 20 million/ml.
- Necrospermia: Dead sperm.
- Abnormal shapes: Greater than 10% with atypical shapes (giant sperm, dwarf sperm, sperm with two heads, sperm with two tails).
Cell Division
-
Mitosis
- One parent cell divides into two daughter cells
- Daughter cells have the same number of chromosomes as the parent cell
- Daughter cells have the same amount of DNA as the parent cell
- Occurs in somatic cells for growth and repair.
-
Meiosis
- One parent cell divides into four daughter cells
- Daughter cells have half the number of chromosomes as the parent cell
- Daughter cells have half the amount of DNA as the parent cell
- Occurs in germ cells for reproduction
Abnormal Meiosis (Nondisjunction)
- Nondisjunction occurs when a pair of homologous chromosomes fails to separate during meiosis.
- Can occur in autosomes or sex chromosomes.
- Occurs more frequently in ova due to advanced maternal age.
- One daughter cell receives 24 chromosomes and the other 22 chromosomes.
- When an abnormal gamete fertilizes a normal gamete (23 chromosomes), it results in:
- Trisomy (47 chromosomes) such as Down syndrome (trisomy 21), Klinefelter syndrome (44+XXY), and superfemale syndrome (44+XXX).
- Monosomy (45 chromosomes) such as Turner syndrome (44+XO).
Gametogenesis
- Gametogenesis is the process of forming gametes (sperm or ovum).
- It occurs in the gonads (testis & ovary).
- Aim
- Prepare germ cells for fertilization
- Reduce the number of chromosomes from diploid to haploid.
Spermatogenesis
- The transformation of a spermatogonium into a sperm.
- Occurs in the seminiferous tubules of the testes.
- Begins at puberty and continues throughout life.
- Duration: Approximately 2 months.
Oogenesis
- Process by which an oogonium is transformed into a mature ovum.
- Occurs in the cortex of the ovary.
- Begins in intrauterine life and continues until menopause.
Oogenesis Before Birth
- Oogonia divide by mitosis to form daughter oogonia (46 chromosomes, 2n DNA).
- Daughter oogonia replicate and differentiate into primary oocytes (46 chromosomes, 4n DNA).
- Primary oocytes enter the first meiotic division but are arrested in prophase until puberty.
- At birth, a female's ovaries contain about 2 million primary oocytes.
Oogenesis At Puberty
- Only 40,000 primary oocytes are present at puberty.
- Every month, 5-15 primary oocytes complete the first meiotic division, producing one secondary oocyte (23 chromosomes, 2n DNA) and one first polar body.
- The secondary oocyte and the first polar body enter the second meiotic division and arrest at metaphase until fertilization.
Oogenesis After Fertilization
- If fertilization occurs, the secondary oocyte completes the second meiotic division, producing a mature ovum (23 chromosomes, 1n DNA) and a second polar body.
- If fertilization does not occur, the secondary oocyte and the first polar body degenerate.
Oogenesis Note
- Only about 480 secondary oocytes develop during a woman's reproductive life.
Spermatocytogenesis
- Spermatogonia undergo mitosis to produce daughter spermatogonia (46 chromosomes, 2n DNA)
- Daughter spermatogonia replicate and differentiate into primary spermatocytes (46 chromosomes, 4n DNA)
- Primary spermatocytes undergo the first meiotic division to produce two secondary spermatocytes (23 chromosomes, 2n DNA)
- Secondary spermatocytes undergo the second meiotic division to produce two spermatids (23 chromosomes, 1n DNA)
Spermiogenesis
- Spermiogenesis is the morphological transformation of a spermatid into a mature sperm.
- The nucleus forms most of the head.
- The Golgi apparatus surrounds the anterior two-thirds of the nucleus to form the acrosome.
- The mitochondria and two centrioles move to the opposite pole.
- The centriole elongates to form the tail while the mitochondria forms a sheath that surrounds the proximal part of the tail.
- Most of the cytoplasm is shed.
Mature Sperm Components
- Head: Contains the haploid number of chromosomes (22 + X/Y, n).
- Head: The anterior two-thirds are covered by the acrosome.
- Neck: Contains the centriole.
-
Tail:
- Middle piece: Contains the mitochondrial sheath surrounding the proximal part of the tail.
- Principal piece: The longest part that provides sperm motility.
- End piece:
Seminal Fluid
-
Source:
- Sperms: Formated in the testis.
- Fluid: From the prostate, seminal vesicle, and bulbourethral glands.
-
Characters:
-
Sperms:
- Number: 200–600 million
- Motility: More than 80% are motile.
-
Fluid:
- Volume: 3-5 cc per ejaculation
- Color: White
- Odor: Seminiferous odor
- Reaction: Alkaline
-
Sperms:
-
Function:
- Contains fructose for sperm nutrition.
- Essential for sperm motility.
- Neutralizes vaginal acidity.
Abnormal Seminal Fluid
-
In number:
- Azoospermia: Absent sperms.
- Oligospermia: Sperm count less than 20 million per ml.
-
In motility:
- Necrospermia: Dead sperms.
-
In shape:
- Normally less than 10% are abnormal.
- Giant sperms: Very big sperms.
- Dwarf sperms: Very small sperms.
- Sperm with 2 heads.
- Sperm with 2 tails.
Cell Division
-
Mitosis:
- One parent cell divides into two daughter cells.
- All cells have the same number of chromosomes.
- All cells have the same amount of DNA.
- Occurs in autosomal cells for growth or tissue repair.
-
Meiosis:
- One parent cell divides into four daughter cells.
- Each daughter cell has half the number of chromosomes in the parent cell.
- Each daughter cell has half the amount of DNA present in the parent cell.
- Occurs in germ cells for reproduction.
Abnormal Meiosis (Nondisjunction)
- Non-separation of a pair of homologous chromosomes during meiosis.
- May occur in the autosomes or sex chromosomes.
- Usually occurs in the ova due to advanced maternal age.
- One cell receives 24 chromosomes and the other receives 22 chromosomes.
Fertilization of Abnormal Gametes
- Fertilization of an abnormal gamete (24 or 22 chromosomes) with a normal gamete (23 chromosomes) results in:
-
An individual of trisomy (47 chromosomes), e.g.:
- Down syndrome (trisomy 21)
- Klinefelter syndrome (44+XXY)
- Superfemale syndrome (44+XXX)
-
An individual of monosomy (45 chromosomes), e.g.:
- Turner syndrome (44+XO)
-
Gametogenesis
- The process of formation of gametes (sperm or ovum)
- Site: Gonads (testis and ovary)
-
Aim:
- Preparation of germ cells for fertilization.
- Reduction of the number of chromosomes from diploid to haploid.
Spermatogenesis
- The transformation of a spermatogonium into sperm.
- Site: Seminiferous tubules of the testis.
- Time: From puberty and continues until old age.
- Duration: About 2 months
Oogenesis
- Process by which an oogonium is transformed into a mature ovum.
- Site: Cortex of the ovary.
- Time: From intrauterine life to menopause.
Oogenesis: Before Birth
- Oogonia undergo mitosis giving daughter oogonia (46 chromosomes, 2n DNA).
- Daughter oogonia replicate and differentiate into primary oocytes (46 chromosomes, 4n DNA).
- Primary oocytes enter the first meiotic division but become arrested in prophase until puberty.
- The female is born with ovaries containing about 2 million primary oocytes.
- Only 40,000 primary oocytes are present at puberty.
Oogenesis: After Puberty
- Every month, about 5-15 primary oocytes complete the first meiotic division giving:
- One secondary oocyte (23 chromosomes, 2n DNA)
- One first polar body.
- Both the secondary oocyte and the first polar body enter the second meiotic division and are arrested at metaphase until fertilization.
- If fertilization occurs, the secondary oocyte completes the second meiotic division, giving a mature ovum (23 chromosomes, 1n DNA) and a second polar body.
- If fertilization does not occur, both the secondary oocyte and the first polar body degenerate.
- Only about 480 secondary oocytes develop during the reproductive life of the female.
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