48 Questions
What is the result of any structural or functional acrosomal abnormality impairing sperm fusion?
Decreased fertility
What is the role of cortical granules in the egg-sperm binding process?
Prevention of polyspermy
What can lead to a decreased effective block to polyspermy?
Aged ova
What is the fate of embryos with triploidy in vitro?
They are discarded
What is the role of PLC-zeta in egg activation?
generating calcium (Ca2+) oscillations that induce egg activation and early embryonic development during mammalian fertilization
What is the immediate result of pronuclei fusion during fertilization?
Formation of the diploid zygote nucleus
What follows the formation of the diploid zygote nucleus during fertilization?
Series of mitotic cell divisions
What is the stage of development following the 8-cell stage?
Morula
What is the term for the study of the development of the zygote?
Embryology
What are the stages of development following the 2-cell stage?
4-cell stage, 8-cell stage, Morula
What is the consequence of excessive sperm numbers at the site of fertilization?
Increased chance of polyspermy
What is the result of the breakdown of the nuclear envelope during pronuclei fusion?
Formation of a circle of small vesicles
What is the primary site for the capacitation of sperm?
Epididymis
What is the absolute requirement for capacitation changes in sperm?
Biochemical changes to sperm
Which of the following glycoproteins is NOT essential for fertilization?
ZP1
What is the role of Zona Pellucida (ZP) in sperm-egg binding?
Prevention of polyspermy
What is the evidence demonstrating sperm capacitation from the early IVF experiments?
Fertilization occurred when ejaculated sperm were added to uterine fluid and then added to an oocyte
What causes the release of acrosomal contents via exocytosis in the sperm-egg binding process?
Progesterone binding to receptors on ZP
Where are sperm deposited and how do they travel to the site of fertilization?
Vagina and travel to tubal ampulla
What is the role of ovarian steroids in sperm transport?
Increase uterine contractility
Which of the following is responsible for sperm-egg binding and induction of acrosomal reaction?
Heterocomplexes of ZP3 and ZP4
What causes the activation of Zona Pellucida receptors (ZP) on the cell surface of the sperm?
Increased cAMP and PKA activity
What is the primary site for the production of sperm?
Seminiferous tubules
What is the role of the Zona Pellucida (ZP) in the sperm-egg binding process?
Prevention of polyspermy
What is the role of cortical granules in the egg-sperm binding process?
Prevention of polyspermy
What is the immediate result of pronuclei fusion during fertilization?
Formation of the diploid zygote nucleus
What is the consequence of excessive sperm numbers at the site of fertilization?
Increased chance of polyspermy
What is the result of any structural or functional acrosomal abnormality impairing sperm fusion?
Infertility
What is the role of PLC-zeta in egg activation?
Induction of intracellular calcium release
What is the fate of embryos with triploidy in vitro?
Discarded
What follows the formation of the diploid zygote nucleus during fertilization?
Cleavage
What is the primary site for the production of sperm?
Testes
What is the role of Zona Pellucida (ZP) in the sperm-egg binding process?
Activation of Zona Pellucida receptors
What is the evidence demonstrating sperm capacitation from the early IVF experiments?
Increased fertilization potential
What is the stage of development following the 8-cell stage?
Morula
What is the primary site for the capacitation of sperm?
Fallopian tubes
What is the primary function of capacitation in sperm?
Increase in pH within the sperm and activation of Zona Pellucida receptors
What is the role of Zona Pellucida glycoproteins ZP3 and ZP4 in the sperm-egg binding process?
Responsible for sperm-egg binding and induction of acrosomal reaction
What causes the release of acrosomal contents via exocytosis in the sperm-egg binding process?
Calcium-mediated signal transduction cascade
What is the immediate result of pronuclei fusion during fertilization?
Formation of the diploid zygote nucleus
What is the primary site for the production of sperm?
Seminiferous tubules
What is the consequence of excessive sperm numbers at the site of fertilization?
Increased likelihood of polyspermy
What is the fate of embryos with triploidy in vitro?
Developmental arrest
What is the role of ovarian steroids in sperm transport?
Influence uterine contractility
What is the term for the study of the development of the zygote?
Embryology
What is the role of cortical granules in the egg-sperm binding process?
Prevention of polyspermy
What follows the formation of the diploid zygote nucleus during fertilization?
Developmental stages leading to blastocyst formation
What is the role of PLC-zeta in egg activation?
Induces intracellular calcium oscillations
Test your knowledge of sperm maturation and capacitation with this quiz! Explore the biochemical changes and physiological processes that transform sperm into a state capable of fertilization. Dive into the evidence from early IVF experiments to understand the crucial role of capacitation in the fertilization process.
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