Spatial Localization of mRNAs

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Questions and Answers

What is the primary function of RNA localization elements?

To regulate gene expression through inhibition of protein synthesis

To facilitate the degradation of mRNAs with specific sequences

To enhance the translation of mRNAs with secondary structures

To mediate the localization of mRNAs to specific regions within the cell (correct)

Which of the following is NOT a type of cytoskeleton involved in mRNA transport?

Microfilaments

Intermediate filaments

Microtubules

Centrioles (correct)

What is the primary function of RNA-binding proteins in mRNA localization?

To inhibit the translation of mRNAs with secondary structures

To degrade mRNAs with specific sequences

To act as adaptors, linking mRNAs to motor proteins or the cytoskeleton (correct)

To facilitate the transport of mRNAs to the nucleus

Which of the following is an example of a subcellular region where mRNAs can be localized?

Dendrites in neurons Signup and view all the answers

What is the primary function of the cytoskeleton in mRNA trafficking?

To provide a framework for mRNA transport Signup and view all the answers

What is the significance of subcellular mRNA distribution?

It is critical for proper cellular function and development Signup and view all the answers

What is the primary requirement for translation to occur in a cell?

mRNAs must be accessible to ribosomes Signup and view all the answers

In which organisms can mRNAs move to the daughter cell during budding?

Yeast Signup and view all the answers

Where can tRNAs and mRNAs be localized in all cells?

In the vicinity of mitochondria Signup and view all the answers

In which stage of development do mRNAs move to a single pole of the syncytium?

During embryogenesis in insects Signup and view all the answers

What is responsible for covering mRNAs after transcription in the nucleus?

Proteins of exportation to the cytoplasm Signup and view all the answers

What is the role of motors in mRNA transport?

To transport mRNAs to different subcellular locations Signup and view all the answers

During the anteroposterior differentiation of Drosophila, what is the characteristic of the gradients of proteins such as BCD or HB-M?

They are more concentrated in the anterior pole than in the posterior pole Signup and view all the answers

In neurons, what is the purpose of mobilizing mRNAs to the zone of synaptic transmission?

To accelerate the response to stimuli by translating proteins on demand Signup and view all the answers

What is the mechanism by which mRNAs are localized to specific poles in the Drosophila embryo?

Through anchoring to specific structures in the pole Signup and view all the answers

In yeast cells, what is the outcome of differential mRNA transport before cell division?

One daughter cell has a distinct mRNA profile compared to the other Signup and view all the answers

What is the role of Bicoid protein in the localization of Caudal protein?

It inhibits the translation of Caudal protein Signup and view all the answers

What is the purpose of the localization of Hunchback protein to the anterior pole?

To establish a gradient of Hunchback protein Signup and view all the answers

What is the role of She2p or She3p proteins in S.cerevisiae?

They recognize and bind to specific mRNA sequences Signup and view all the answers

What is the function of microtubules in mRNA transport?

To transport mRNAs along with motor proteins Signup and view all the answers

What is the role of Puf3 protein in the localization of mRNAs?

It anchors mRNAs to the mitochondrial membrane Signup and view all the answers

In fibroblasts, what happens to mRNAs in response to a stimulus that induces cellular movement?

They are transported to the leading edge of the cell to synthesize proteins Signup and view all the answers

Why are mRNAs localized to the vicinity of the mitochondria?

To localize the corresponding proteins to the mitochondrial membrane Signup and view all the answers

What is the outcome of active mRNA transport in cells?

Selective concentration of mRNAs in specific regions Signup and view all the answers

What is the consequence of the inhibition of Hunchback protein translation by Nanos protein?

Hunchback protein is localized to the anterior pole Signup and view all the answers

What is the result of the localization of mRNAs to specific poles in the Drosophila embryo?

A gradient of proteins with different concentrations in each pole Signup and view all the answers

Study Notes