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Questions and Answers
What is the primary purpose of using excipients in solid dosage form formulations?
Which manufacturing method for tablets does NOT typically involve moisture?
What percentage of all dosage forms used for systemic administration is constituted by solid dosage forms?
What is a disadvantage of the wet granulation method in tablet manufacturing?
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Which of the following is NOT a rationale for the use of solid dosage forms?
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What is the main advantage of using the dry granulation method?
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Which solid dosage form is not commonly included in the solid dosage forms category?
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What is one of the goals of optimizing the absorption rate of a drug in solid dosage forms?
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What is a significant challenge when manufacturing tablets?
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Why can the absorption of therapeutic agents from tablets vary between patients?
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Which type of tablet is characterized by providing rapid disintegration?
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What is one method of overcoming difficulties in swallowing tablets, particularly for children and the elderly?
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Which type of tablet consists of at least two layers?
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What is a characteristic feature of compression coated tablets?
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What type of tablet would be most suitable for delivering medication sublingually?
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What is one disadvantage associated with the compression properties of some therapeutic agents in tablet production?
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What is the primary benefit of using multiple compressed tablets?
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Which of the following describes enteric-coated tablets?
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What role do polymeric excipients play in multiple compressed tablets?
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Which of the following polymers is commonly used for enteric coatings?
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What is typically the core of a multi-layered tablet?
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What is a primary advantage of using enteric-coated tablets for certain drugs?
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Which statement is true regarding the layers in a multiple compressed tablet?
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How do enteric-coating polymers, like Methacrylic acid co-polymers, function?
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What advantage does the gelatin coating offer to Gelcap tablets compared to regular capsules?
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Which type of tablet is designed to disintegrate and release medication without any controlling features?
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For which patient population are Rapidly Disintegrating or Dissolving Tablets primarily designed?
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What is a primary use of effervescent tablets?
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What characteristic distinguishes Modified Release Tablets from Immediate Release Tablets?
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What is the primary reason for sugar-coating tablets?
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Which polymer is commonly used for film-coating tablets?
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What advantage do film-coated tablets have over sugar-coated tablets?
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Which type of tablet is specifically designed for patients who have difficulty swallowing conventional tablets?
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What role does a plasticizer play in film-coated tablets?
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What is a characteristic of effervescent tablets when added to aqueous solutions?
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Which of the following statements about film coatings is false?
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Why are chewable tablets not typically used for drugs with taste issues?
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Study Notes
Solid Dosage Forms - Tablets
- Solid dosage forms are the most common type of dosage form used for systemic administration of therapeutic agents.
- Tablets are a type of solid dosage form, often formulated to optimize drug absorption, ease of administration, and control the rate and site of absorption.
- Tablet formulation uses various components to ensure manufacturability and control biological performance.
- Three main methods for tablet manufacturing are: wet granulation, dry granulation (slugging or roller compaction), and direct compression.
- Each manufacturing method has advantages and disadvantages.
Different Types of Tablets
- Conventional compressed tablets disintegrate rapidly for quick drug release, constituting a significant portion of clinically used tablets.
- Multiple compressed tablets consist of at least two layers, allowing for the separation of incompatible drugs, controlled release, or targeted drug delivery to different gastrointestinal sites.
- Enteric-coated tablets are coated with polymers that dissolve in the small intestine but not in the stomach, protecting the drug from degradation or gastric irritation.
- Sugar-coated tablets are coated with sugar solutions to improve appearance and mask bitter taste, but are less common than film-coated tablets.
- Film-coated tablets are coated with polymers for improved mechanical properties and appearance, often deposited on embossed markings.
- Chewable tablets are designed for easy administration to children and adults, particularly for antacid formulations.
- Effervescent tablets rapidly disintegrate in aqueous solutions, producing a suspension or solution, often for poorly soluble drugs.
- Rapidly disintegrating or dissolving tablets (RD Tablets) are characterized by their quick disintegration in the mouth, within 1 minute or even 10 seconds, making them convenient for patients with difficulty swallowing tablets.
Coating
- Coating with polymers allows for targeted drug release within the gastrointestinal tract, such as the small intestine or colon.
- Insoluble film coating allows for sustained release of drug by diffusion.
- Gelatin-coated tablets, or gelcaps, are capsule-shaped compressed tablets providing smaller size and ease of swallowing.
- Different types of coated tablets: Immediate release, Modified release, Controlled release (Sustained/Extended release, Delayed release), and Rapidly disintegrating/dissolving tablets.
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Description
Explore the fascinating world of solid dosage forms, particularly tablets, which are among the most common methods of administering therapeutic agents. This quiz covers tablet types, formulation components, and manufacturing methods, including wet granulation and direct compression. Test your knowledge on the principles that optimize drug absorption and delivery.
