Tablet Excipients and Binders in Tablet Formulation

What is the primary purpose of adding lubricants to a tablet formulation?

To increase the tablet strength
To reduce the friction between the tablet and the die wall during ejection (correct)
To improve tablet disintegration and dissolution
To enhance the flow properties of the powder or granules

Why are hydrophobic lubricants like stearic acid and its salts preferred over hydrophilic lubricants?

Hydrophobic lubricants are cheaper and more readily available
Hydrophobic lubricants are less likely to interfere with tablet disintegration and dissolution (correct)
Hydrophobic lubricants are more compatible with the other tablet excipients
Hydrophobic lubricants are more effective at reducing friction

What is the recommended concentration range for the use of stearic acid and its salts as lubricants in tablet formulations?

Less than 0.1% w/w
Less than 1% w/w (correct)
Between 1% and 5% w/w
Greater than 5% w/w

Which of the following is NOT a common lubricant used in tablet technology?

Microcrystalline cellulose (C) Signup and view all the answers

Why is it important to minimize the mixing time and intensity when incorporating lubricants into a tablet formulation?

To prevent the lubricant from coating the other excipients (D) Signup and view all the answers

What is the primary function of glidants in a tablet formulation?

To improve the flow properties of the powder or granules (D) Signup and view all the answers

What is the role of disintegrants in tablet formulations?

To facilitate the disintegration and subsequent dissolution of the tablet. (A) Signup and view all the answers

Which statement is true regarding the relationship between disintegrant concentration and disintegration rate?

The disintegration rate increases with increasing disintegrant concentration until a maximum, after which it decreases. (C) Signup and view all the answers

Which of the following is NOT listed as a factor influencing the action of disintegrants?

The solubility of the drug substance in the formulation. (D) Signup and view all the answers

What is the likely mechanism of action of 'super disintegrants'?

They act by a combination of proposed theories including water wicking, swelling, deformation recovery, repulsion, and heat of wetting. (B) Signup and view all the answers

Which of the following is NOT listed as a common disintegrant used in tablet manufacturing?

Sodium starch glycolate (B) Signup and view all the answers

What is the purpose of adding disintegrants intragranularly, extragranularly, or both during tablet manufacturing?

To achieve the best disintegration result. (D) Signup and view all the answers

What is the primary function of disintegrants in tablet formulations?

To facilitate the breakdown of the tablet into smaller granules for improved drug release (A) Signup and view all the answers

Which of the following mechanisms is NOT commonly associated with the disintegration of tablets?

Decreased tablet porosity (B) Signup and view all the answers

Which of the following disintegrants is NOT mentioned in the text?

Sodium carboxymethylcellulose (D) Signup and view all the answers

Which of the following tablet disintegration mechanisms involves the production of gas?

Effervescent reaction (A) Signup and view all the answers

Which of the following is NOT listed as an example of a bulking agent used in tablet manufacture?

Magnesium stearate (B) Signup and view all the answers

Why is the use of excessive binder in tablet formulation discouraged?

It makes a hard tablet that does not disintegrate easily when in contact with moisture. (B) Signup and view all the answers

Why are bulking agents added to tablet formulations?

To increase the tablet weight for better handling during manufacturing. (A) Signup and view all the answers

Which property is NOT an ideal characteristic of bulking agents for tablets?

Hygroscopic nature (B) Signup and view all the answers

What is a key consideration when determining the quantity of bulking agent to add to a tablet formulation?

The quantity of the drug substance (A) Signup and view all the answers

Why is lactose commonly used as a bulking agent in tablet and capsule formulations?

It fulfills most ideal characteristics of bulking agents. (C) Signup and view all the answers

What happens if a tablet contains too much binder?

It will not disintegrate easily in contact with moisture. (A) Signup and view all the answers

What is the primary purpose of using glidants in tablet manufacturing?

To enhance the flow of powders or granules during compression (C) Signup and view all the answers

Which property of glidants contributes to their ability to enhance powder flow?

Their hydrophobic nature and ability to locate within spaces between powder particles (D) Signup and view all the answers

Which of the following is NOT a commonly used glidant in tablet manufacturing?

Magnesium stearate (D) Signup and view all the answers

What is the potential downside of using too high a concentration of glidants in a tablet formulation?

It may adversely affect tablet disintegration and drug dissolution (A) Signup and view all the answers

What is the typical concentration range for colloidal silica as a glidant in tablet formulations?

0.2 to 3% w/w (C) Signup and view all the answers

Which of the following excipients is used to reduce the sticking or adhesion of powders or granules to the punch faces during tablet compression?

Antiadherents (C) Signup and view all the answers