29 Questions
What is the primary purpose of adding lubricants to a tablet formulation?
To reduce the friction between the tablet and the die wall during ejection
Why are hydrophobic lubricants like stearic acid and its salts preferred over hydrophilic lubricants?
Hydrophobic lubricants are less likely to interfere with tablet disintegration and dissolution
What is the recommended concentration range for the use of stearic acid and its salts as lubricants in tablet formulations?
Less than 1% w/w
Which of the following is NOT a common lubricant used in tablet technology?
Microcrystalline cellulose
Why is it important to minimize the mixing time and intensity when incorporating lubricants into a tablet formulation?
To prevent the lubricant from coating the other excipients
What is the primary function of glidants in a tablet formulation?
To improve the flow properties of the powder or granules
What is the role of disintegrants in tablet formulations?
To facilitate the disintegration and subsequent dissolution of the tablet.
Which statement is true regarding the relationship between disintegrant concentration and disintegration rate?
The disintegration rate increases with increasing disintegrant concentration until a maximum, after which it decreases.
Which of the following is NOT listed as a factor influencing the action of disintegrants?
The solubility of the drug substance in the formulation.
What is the likely mechanism of action of 'super disintegrants'?
They act by a combination of proposed theories including water wicking, swelling, deformation recovery, repulsion, and heat of wetting.
Which of the following is NOT listed as a common disintegrant used in tablet manufacturing?
Sodium starch glycolate
What is the purpose of adding disintegrants intragranularly, extragranularly, or both during tablet manufacturing?
To achieve the best disintegration result.
What is the primary function of disintegrants in tablet formulations?
To facilitate the breakdown of the tablet into smaller granules for improved drug release
Which of the following mechanisms is NOT commonly associated with the disintegration of tablets?
Decreased tablet porosity
Which of the following disintegrants is NOT mentioned in the text?
Sodium carboxymethylcellulose
Which of the following tablet disintegration mechanisms involves the production of gas?
Effervescent reaction
Which of the following is NOT listed as an example of a bulking agent used in tablet manufacture?
Magnesium stearate
Why is the use of excessive binder in tablet formulation discouraged?
It makes a hard tablet that does not disintegrate easily when in contact with moisture.
Why are bulking agents added to tablet formulations?
To increase the tablet weight for better handling during manufacturing.
Which property is NOT an ideal characteristic of bulking agents for tablets?
Hygroscopic nature
What is a key consideration when determining the quantity of bulking agent to add to a tablet formulation?
The quantity of the drug substance
Why is lactose commonly used as a bulking agent in tablet and capsule formulations?
It fulfills most ideal characteristics of bulking agents.
What happens if a tablet contains too much binder?
It will not disintegrate easily in contact with moisture.
What is the primary purpose of using glidants in tablet manufacturing?
To enhance the flow of powders or granules during compression
Which property of glidants contributes to their ability to enhance powder flow?
Their hydrophobic nature and ability to locate within spaces between powder particles
Which of the following is NOT a commonly used glidant in tablet manufacturing?
Magnesium stearate
What is the potential downside of using too high a concentration of glidants in a tablet formulation?
It may adversely affect tablet disintegration and drug dissolution
What is the typical concentration range for colloidal silica as a glidant in tablet formulations?
0.2 to 3% w/w
Which of the following excipients is used to reduce the sticking or adhesion of powders or granules to the punch faces during tablet compression?
Antiadherents
Learn about tablet excipients such as bulking agents and binders used in tablet formulation for pharmaceutical manufacturing. Understand the impact of excessive binder usage on tablet hardness and disintegration. Explore the role of excipients in increasing the size of tablets with small quantities of active pharmaceutical ingredients.
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