17 Questions
What is the main function of Tumour Suppressor genes?
To protect cells from cancer
What type of mutation is required to convert a proto-oncogene into an oncogene?
Gain of function mutation
What is true about oncogenes?
They need to be over-activated by mutations
What type of mutation is required to inactivate a Tumour Suppressor gene?
Loss of function mutation
What is true about Molecularly Dominant oncogenes?
Only one defective copy of the gene is required to provide oncogenic phenotype
What is the notation for a substitution of the C nucleotide at position 4375 with a T?
c.4375C>T
What is the definition of a SNP?
A single DNA base variation found in more than 1% of a population
What is the notation for the duplication of nucleotides from position 4375 to 4385?
c.4375_4385dupCGATTATTCCA
What is the notation for the deletion of nucleotides from position 4375 to 4379?
c.4375_4379delCGATT
What is the purpose of the COSMIC database?
To collect and integrate somatic mutation data
What is the primary reason for genetic variations in humans?
Insertions, deletions, and mutations of nucleotide base
What is the notation for a protein mutation of Arg to His at position 11?
p.Arg11His
What is the most common type of genetic variation amongst people?
Single Nucleotide Polymorphism (SNP)
What is the effect of genetic variations in the coding region on the amino acid sequence?
It alters the amino acid sequence
What percentage of DNA sequence is shared among all humans?
99%
Why do some people respond to treatment and not others?
Due to genetic variations
What is the result of genetic variation in terms of physical characteristics?
Variation in physical characteristics, such as hair color and skin color
This quiz is about Single Nucleotide Polymorphisms (SNPs) and mutations in DNA sequences, including their definitions and notations. Learn about the different types of DNA variations and their effects on genes and proteins.
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