S.maltophilia and Antimicrobial Resistance in VAP
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Questions and Answers

What is the mortality rate of patients infected with multidrug-resistant isolates of S.maltophilia?

  • 71.4-80%
  • 50-60%
  • 60-71.4% (correct)
  • 37-50%

What is the approximate percentage of VAP etiology that involves S.maltophilia?

  • 40-50%
  • 9-27% (correct)
  • 5-15%
  • 27-40%

What is a major risk factor for the colonization of S.maltophilia, leading to VAP?

  • Chronic obstructive pulmonary disease (COPD)
  • Old age
  • Use of corticosteroids
  • Use of mechanical ventilation (correct)

What is the primary location where VAP predominantly occurs?

<p>Intensive Care Units (ICUs) (B)</p> Signup and view all the answers

What is a common characteristic of patients who develop VAP due to S.maltophilia?

<p>Severe diseases (B)</p> Signup and view all the answers

What is a consequence of the serious broad-spectrum resistance of S.maltophilia to antibiotics?

<p>Prolonged hospital stay (D)</p> Signup and view all the answers

What is a major challenge in treating VAP due to S.maltophilia?

<p>Lack of effective antimicrobial therapy (A)</p> Signup and view all the answers

What is the main goal of summarizing the current evidence and clinical management of VAP due to S.maltophilia?

<p>To provide better management recommendations (D)</p> Signup and view all the answers

Flashcards

Mortality rate of MDR S.maltophilia?

High, ranging from 60-71.4%.

S.maltophilia's role in VAP?

Approximately 9-27% of cases.

VAP risk factor: S.maltophilia?

Reliance on machine-assisted breathing.

Where does VAP mainly occur?

Intensive Care Units.

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Who's prone to S.maltophilia VAP?

Often those with serious underlying conditions.

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Consequence of S.maltophilia's resistance?

Longer time spent in the hospital.

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Challenge in treating S.maltophilia VAP?

Finding drugs that can effectively combat it.

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Goal for managing S.maltophilia VAP?

Improving treatment strategies via current data.

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Study Notes

Ventilator-Associated Pneumonia (VAP)

  • VAP is the most prevalent hospital-acquired infection in the ICU, resulting in significant morbidity and mortality.
  • 9-27% of all VAP etiology involves S.maltophilia, particularly in patients with severe diseases.

Stenotrophomonas maltophilia (S.maltophilia)

  • S.maltophilia is a virulent opportunistic pathogen that leads to pneumonia in populations with depleted immunity or serious chronic diseases.
  • The use of mechanical ventilation is an important risk factor for colonization, which exacerbates pneumonia.

Treatment and Mortality Rate

  • The serious broad-spectrum resistance of S.maltophilia to antibiotics has led to a difficult treatment of VAP due to S.maltophilia.
  • Mortality rate of patients infected with multidrug-resistant isolates was 60-71.4%, much higher than the 37-50% mortality rate found in the antibiotic-sensitive group.

Clinical Management of VAP due to S.maltophilia

  • There is a need for better management recommendations for VAP due to S.maltophilia, a fatal pathogen.
  • There is a lack of new antimicrobial resistance management studies on VAP with multiple drug-resistant S.maltophilia.

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Description

This quiz covers the impact of S.maltophilia on ventilator-associated pneumonia (VAP) treatment, including antibiotic resistance and mortality rates. It also touches on antimicrobial therapy and new antimicrobial agents.

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