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Sleep Lecture SG Questions

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Questions and Answers

Which medication is a CYP3A4 inhibitor that can elevate concentrations of CYP3A4 metabolized medications?

Ramelteon

Grapefruit juice (correct)

Mirtazapine

Alcohol

What is the advised action if a patient asks to take two 8 mg doses of Ramelteon due to insomnia?

Advise the patient to take the two 8 mg doses as requested

Advise the patient to consult their doctor before taking any additional Ramelteon

Advise the patient to take only the 8 mg dose that was studied for efficacy and safety (correct)

Advise the patient to take a different medication for insomnia

Which two antidepressants are commonly prescribed at low doses for insomnia?

Mirtazapine (Remeron) and trazodone (correct)

Bupropion (Wellbutrin) and venlafaxine (Effexor)

Citalopram (Celexa) and escitalopram (Lexapro)

Fluoxetine (Prozac) and sertraline (Zoloft)

What is the active ingredient in Advil PM and Tylenol PM for sleep, and what are some common side effects?

Diphenhydramine, with common side effects of dry mouth, constipation, and blurry vision (D) Signup and view all the answers

Which tricyclic antidepressant (TCA) is FDA approved for the treatment of insomnia?

Doxepin (Silenor) (A) Signup and view all the answers

What is the most likely indication for a new prescription for Provigil 200 mg taken at 6 PM?

Shift-work (D) Signup and view all the answers

What is the preferred treatment for chronic insomnia?

Cognitive Behavioral Therapy for Insomnia (CBT-I) (A) Signup and view all the answers

What are some non-pharmacological options to treat insomnia?

Deep breathing, Calm app, good sleep hygiene (D) Signup and view all the answers

What are the usual doses of antidepressants used off-label for insomnia?

Mirtazapine 7.5-15 mg/night, Trazodone 50-150 mg/night (A) Signup and view all the answers

What is the potential risk with combining grapefruit juice and certain medications?

Grapefruit juice is a CYP3A4 inhibitor that can elevate concentrations of CYP3A4 metabolized medications (B) Signup and view all the answers

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Questions and Answers

Which medication is a CYP3A4 inhibitor that can elevate concentrations of CYP3A4 metabolized medications?

What is the advised action if a patient asks to take two 8 mg doses of Ramelteon due to insomnia?

Which two antidepressants are commonly prescribed at low doses for insomnia?

What is the active ingredient in Advil PM and Tylenol PM for sleep, and what are some common side effects?

Which tricyclic antidepressant (TCA) is FDA approved for the treatment of insomnia?

What is the most likely indication for a new prescription for Provigil 200 mg taken at 6 PM?

What is the preferred treatment for chronic insomnia?

What are some non-pharmacological options to treat insomnia?

What are the usual doses of antidepressants used off-label for insomnia?

What is the potential risk with combining grapefruit juice and certain medications?

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