10 Questions
Which medication is a CYP3A4 inhibitor that can elevate concentrations of CYP3A4 metabolized medications?
Grapefruit juice
What is the advised action if a patient asks to take two 8 mg doses of Ramelteon due to insomnia?
Advise the patient to take only the 8 mg dose that was studied for efficacy and safety
Which two antidepressants are commonly prescribed at low doses for insomnia?
Mirtazapine (Remeron) and trazodone
What is the active ingredient in Advil PM and Tylenol PM for sleep, and what are some common side effects?
Diphenhydramine, with common side effects of dry mouth, constipation, and blurry vision
Which tricyclic antidepressant (TCA) is FDA approved for the treatment of insomnia?
Doxepin (Silenor)
What is the most likely indication for a new prescription for Provigil 200 mg taken at 6 PM?
Shift-work
What is the preferred treatment for chronic insomnia?
Cognitive Behavioral Therapy for Insomnia (CBT-I)
What are some non-pharmacological options to treat insomnia?
Deep breathing, Calm app, good sleep hygiene
What are the usual doses of antidepressants used off-label for insomnia?
Mirtazapine 7.5-15 mg/night, Trazodone 50-150 mg/night
What is the potential risk with combining grapefruit juice and certain medications?
Grapefruit juice is a CYP3A4 inhibitor that can elevate concentrations of CYP3A4 metabolized medications
Test your knowledge on sleep phases, REM rebound, and changes in sleep with aging. Questions cover topics such as the benefits of deep sleep, factors causing REM rebound, and how sleep patterns evolve as we age.
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