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Questions and Answers
What is the estimated overall incidence of SLE per 100,000 people?
What is the estimated overall incidence of SLE per 100,000 people?
How much more frequently does SLE occur in women compared to men?
How much more frequently does SLE occur in women compared to men?
Which ethnic group is more susceptible to SLE?
Which ethnic group is more susceptible to SLE?
What is the main mechanism responsible for the clinical manifestations of SLE?
What is the main mechanism responsible for the clinical manifestations of SLE?
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Which type of lupus is mentioned as an alternative to SLE?
Which type of lupus is mentioned as an alternative to SLE?
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What is overexpressed in SLE and helps in the overproduction of antibodies?
What is overexpressed in SLE and helps in the overproduction of antibodies?
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What is the initial trigger for SLE?
What is the initial trigger for SLE?
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What is the estimated incidence of SLE in women compared to men?
What is the estimated incidence of SLE in women compared to men?
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Which organ in the body does SLE affect?
Which organ in the body does SLE affect?
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What is the other form of adult lupus mentioned in the text?
What is the other form of adult lupus mentioned in the text?
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What is the significance of papular, erythematous, and purpuric lesions developing on the fingertips, elbows, toes, and extensor surfaces of the forearms or lateral sides of the hand?
What is the significance of papular, erythematous, and purpuric lesions developing on the fingertips, elbows, toes, and extensor surfaces of the forearms or lateral sides of the hand?
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What is the significance of joint swelling, tenderness, warmth, pain on movement, stiffness, and edema in the context of the assessment?
What is the significance of joint swelling, tenderness, warmth, pain on movement, stiffness, and edema in the context of the assessment?
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What is the significance of a positive antinuclear antibody (ANA) test in the context of the assessment?
What is the significance of a positive antinuclear antibody (ANA) test in the context of the assessment?
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What is the significance of abnormal lung sounds in the cardiovascular assessment?
What is the significance of abnormal lung sounds in the cardiovascular assessment?
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What is the significance of a positive anti-DNA test in the laboratory assessment?
What is the significance of a positive anti-DNA test in the laboratory assessment?
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What is the significance of pleural effusions and infiltrations in the context of the assessment?
What is the significance of pleural effusions and infiltrations in the context of the assessment?
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What is the significance of signs of depression and reports of seizures, chorea, or other central nervous system manifestations in the neurologic assessment?
What is the significance of signs of depression and reports of seizures, chorea, or other central nervous system manifestations in the neurologic assessment?
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What is the significance of the anti-Sm antibody test in the laboratory assessment?
What is the significance of the anti-Sm antibody test in the laboratory assessment?
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What is the significance of the CBC revealing anemia, thrombocytopenia, leukocytosis, or leukopenia?
What is the significance of the CBC revealing anemia, thrombocytopenia, leukocytosis, or leukopenia?
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What is the significance of auscultation for pericardial friction rub in the cardiovascular assessment?
What is the significance of auscultation for pericardial friction rub in the cardiovascular assessment?
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What is hypothesized to play a role in SLE predisposition?
What is hypothesized to play a role in SLE predisposition?
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Which body system is NOT commonly affected by SLE?
Which body system is NOT commonly affected by SLE?
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What is a common cutaneous manifestation in SLE patients?
What is a common cutaneous manifestation in SLE patients?
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What is a common symptom of SLE?
What is a common symptom of SLE?
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What is a common cardiac manifestation of SLE?
What is a common cardiac manifestation of SLE?
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What may renal involvement in SLE lead to?
What may renal involvement in SLE lead to?
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What is a common musculoskeletal symptom in SLE patients?
What is a common musculoskeletal symptom in SLE patients?
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What is implicated in SLE onset as an environmental trigger?
What is implicated in SLE onset as an environmental trigger?
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What is the main attributed cause of immunoregulatory disturbance in SLE?
What is the main attributed cause of immunoregulatory disturbance in SLE?
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What is a characteristic of central nervous system involvement in SLE?
What is a characteristic of central nervous system involvement in SLE?
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Study Notes
Systemic Lupus Erythematosus (SLE) Overview
- Immunoregulatory disturbance in SLE is attributed to genetic, immunologic, hormonal, and environmental factors.
- Multiple genes are implicated in SLE development, with the majority of cases being sporadic and unrelated to family history.
- Female sex hormones, particularly estrogen, are hypothesized to play a role in SLE predisposition.
- Environmental triggers such as cigarette smoke, ultraviolet rays, medications, viral infections, and emotional stress are implicated in SLE onset.
- SLE is an autoimmune, systemic disease that can affect any body system, with chronic states and acute flares.
- Common symptoms of SLE include fever, fatigue, skin rashes, and joint pain and swelling.
- Mucocutaneous, musculoskeletal, renal, nervous, cardiovascular, and respiratory systems are most commonly affected by SLE.
- Up to 85% of SLE patients experience some form of cutaneous manifestation, including subacute cutaneous lupus erythematosus and discoid rash.
- Joint pain and swelling occur in over 90% of SLE patients, often accompanied by morning stiffness.
- Cardiac manifestations of SLE include pericarditis, myocarditis, hypertension, cardiac arrhythmias, and valvular incompetence.
- Renal involvement, known as lupus nephritis, may lead to hypertension and requires careful monitoring and management.
- Central nervous system involvement in SLE encompasses a wide range of neurologic diseases, including psychosis, cognitive impairment, seizures, neuropathies, and strokes.
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Description
Test your knowledge of Systemic Lupus Erythematosus (SLE) with this informative quiz. Explore the genetic, hormonal, and environmental factors contributing to SLE development, as well as the diverse manifestations of this autoimmune disease across multiple body systems.
