15 Questions
What is the peak age at onset for systemic lupus erythematosus (SLE)?
Between 20 and 30 years
What is the prevalence of systemic lupus erythematosus (SLE) in Caucasians?
0.03%
What is the gender distribution among affected patients of systemic lupus erythematosus (SLE)?
90% female
What genetic factors are strongly associated with systemic lupus erythematosus (SLE)?
Polymorphic variants at the HLA locus
What is the prevalence of systemic lupus erythematosus (SLE) in Afro-Caribbeans?
0.2%
What is the characteristic feature of systemic lupus erythematosus (SLE) from an immunological standpoint?
Autoantibody production
Which age group has the peak age at onset for systemic lupus erythematosus (SLE)?
20-30 years
What is the cause of SLE from an immunological standpoint?
Defects in apoptosis
Which genetic factor is strongly associated with systemic lupus erythematosus (SLE)?
HLA locus
What is the gender distribution among affected patients of systemic lupus erythematosus (SLE)?
90% female, 10% male
What is the prevalence of systemic lupus erythematosus (SLE) in Afro-Caribbeans?
0.2%
What is the main cause of the increased mortality in SLE patients?
Premature cardiovascular disease
What is the role of genetic factors in systemic lupus erythematosus (SLE)?
Genetic factors play an important role in SLE.
What is the characteristic feature of SLE from an immunological standpoint?
Autoantibody production
What may cause SLE due to defects in apoptosis or in the clearance of apoptotic cells?
Inappropriate exposure of intracellular antigens on the cell surface
Learn about the prevalence, demographics, and impact of systemic lupus erythematosus (SLE) on patients. Understand the associated morbidity and mortality risks.
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