Questions and Answers
Which skin layer prevents the body from water loss?
Stratum corneum
Which skin layer is mostly apparent in the scalp?
Scalp
Why is mucous membrane generally more permeable than skin?
It lacks keratin
How long does a cell need to reach the stratum corneum?
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What is the weakest part of the basement membrane zone (BMZ)?
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What causes mechanical traction of the skin?
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Where are transient-amplifying cells found in normal skin?
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Which of the following is NOT true about nodules?
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Which keratin pair is characteristic of differentiated epidermal keratinocytes?
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What type of collagen is most prevalent in humans?
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How is the proliferation of keratinocytes increased?
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Which cell is characterized by a binuclear rounded cytoplasmic shape?
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What organelle is definitive of melanophages?
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At what degrees does melanocyte destruction due to cooling occur?
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What condition is parakeratosis NOT typical of?
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Study Notes
Skin Layers and Functions
- The stratum corneum prevents the body from water loss.
Skin Structure
- The stratum compactum is mostly apparent in the scalp.
Mucous Membrane vs Skin
- Mucous membrane is generally more permeable than skin due to its function of absorption and secretion.
Skin Cell Development
- It takes approximately 28 days for a cell to reach the stratum corneum.
- Transient-amplifying cells are found in the germinative layer of normal skin.
Basement Membrane Zone (BMZ)
- The weakest part of the BMZ is the anchoring fibrils.
Skin Traction
- Mechanical traction of the skin is caused by the contraction of underlying muscles.
Keratinocytes
- Keratin pair 1/10 is characteristic of differentiated epidermal keratinocytes.
- The proliferation of keratinocytes is increased by TGF-α and other growth factors.
Collagen
- Type I collagen is the most prevalent type in humans.
Melanocytes and Melanophages
- Melanophages are characterized by the presence of lysosomes.
- Melanocyte destruction due to cooling occurs at temperatures below -4°C to -7°C.
Skin Conditions
- Parakeratosis is not typical of ichthyosis.
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