Podcast
Questions and Answers
What is required for T cell activation, survival, and proliferation?
What is required for T cell activation, survival, and proliferation?
- CD3 zeta chains
- Costimulation (correct)
- Zap-70 Kinase
- Lck kinase
Which receptors help in turning off T cell activation?
Which receptors help in turning off T cell activation?
- CD28 and CD3
- CD80 and CD86
- CTLA-4 and PD-1 (correct)
- Zap-70 Kinase and Lck kinase
What happens if a costimulatory signal is absent during T cell activation?
What happens if a costimulatory signal is absent during T cell activation?
- Increased proliferation
- Anergy (correct)
- Enhanced T cell response
- Downregulation of CD28
Which molecule becomes non-responsive if it encounters anergy?
Which molecule becomes non-responsive if it encounters anergy?
What is the role of CD28 in T cell signaling?
What is the role of CD28 in T cell signaling?
What is the function of Zap-70 Kinase in downstream signaling?
What is the function of Zap-70 Kinase in downstream signaling?
What modification plays a key role in signaling pathways according to the text?
What modification plays a key role in signaling pathways according to the text?
What leads to the recruitment of Lck kinase in intracellular signaling?
What leads to the recruitment of Lck kinase in intracellular signaling?
Which event triggers the phosphorylation of the CD28 receptor?
Which event triggers the phosphorylation of the CD28 receptor?
What happens to T cells when negative costimulation occurs?
What happens to T cells when negative costimulation occurs?
What is the key modification involved in signaling, as mentioned in the text?
What is the key modification involved in signaling, as mentioned in the text?
Which type of receptor signaling is initiated by recruitment of another kinase and dimerization followed by transphosphorylation?
Which type of receptor signaling is initiated by recruitment of another kinase and dimerization followed by transphosphorylation?
What type of domain can recognize phosphorylated tyrosine on other proteins?
What type of domain can recognize phosphorylated tyrosine on other proteins?
Which proteins are targeted for degradation by the proteasome or in lysosomes?
Which proteins are targeted for degradation by the proteasome or in lysosomes?
What are proteins that dephosphorylate other proteins called?
What are proteins that dephosphorylate other proteins called?
Which modification can function to both activate and inhibit signaling?
Which modification can function to both activate and inhibit signaling?
What is required for optimal T-cell activation and proliferation according to the text?
What is required for optimal T-cell activation and proliferation according to the text?
In which signal does TCR binding initiate signaling?
In which signal does TCR binding initiate signaling?
What is the role of CD28 in T cell signaling?
What is the role of CD28 in T cell signaling?
In T cell signaling, what happens if the costimulatory signal is absent?
In T cell signaling, what happens if the costimulatory signal is absent?
What function does CTLA-4 serve in T cell activation?
What function does CTLA-4 serve in T cell activation?
What event triggers the recruitment of Lck kinase in intracellular signaling?
What event triggers the recruitment of Lck kinase in intracellular signaling?
Which modification plays a vital role in turning off T cell activation according to the text?
Which modification plays a vital role in turning off T cell activation according to the text?
What is the result of clonal anergy in T cells?
What is the result of clonal anergy in T cells?
How is signaling initiated in receptors with intrinsic kinase activity?
How is signaling initiated in receptors with intrinsic kinase activity?
What is the function of SH2 domain in molecular interactions?
What is the function of SH2 domain in molecular interactions?
Which protein modification targets proteins for degradation?
Which protein modification targets proteins for degradation?
What is the role of phosphatases in signaling pathways?
What is the role of phosphatases in signaling pathways?
Which signal directs T-cell differentiation into distinct effector cell types?
Which signal directs T-cell differentiation into distinct effector cell types?
What is required for optimal T-cell activation and proliferation?
What is required for optimal T-cell activation and proliferation?
What triggers the formation of multimolecular complexes around adaptor proteins?
What triggers the formation of multimolecular complexes around adaptor proteins?
What modification plays a key role in both activating and inhibiting signaling pathways?
What modification plays a key role in both activating and inhibiting signaling pathways?
Which event is crucial for turning off T-cell activation?
Which event is crucial for turning off T-cell activation?
What is the primary purpose of adaptor proteins in intracellular signaling?
What is the primary purpose of adaptor proteins in intracellular signaling?
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