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Questions and Answers
What is the primary role of receptor tyrosine kinases (RTKs)?
What is the primary role of receptor tyrosine kinases (RTKs)?
How does deregulation of tyrosine kinases (TKs) impact cell signaling?
How does deregulation of tyrosine kinases (TKs) impact cell signaling?
What is the main consequence of evading immune destruction through retroviral oncogenes hijacking normal genes?
What is the main consequence of evading immune destruction through retroviral oncogenes hijacking normal genes?
Which type of phosphorylation event is predominant among substrate proteins?
Which type of phosphorylation event is predominant among substrate proteins?
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How are receptor tyrosine kinases (RTKs) classified based on their structure?
How are receptor tyrosine kinases (RTKs) classified based on their structure?
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What percentage of the human genome is comprised of protein kinases?
What percentage of the human genome is comprised of protein kinases?
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What is the primary function of protein kinases?
What is the primary function of protein kinases?
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What is unique about the catalytic domain of tyrosine kinases?
What is unique about the catalytic domain of tyrosine kinases?
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What is the function of receptor tyrosine kinases (RTKs)?
What is the function of receptor tyrosine kinases (RTKs)?
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What percentage of oncogenes are tyrosine kinases?
What percentage of oncogenes are tyrosine kinases?
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What is the relative abundance of tyrosine phosphorylation compared to serine phosphorylation?
What is the relative abundance of tyrosine phosphorylation compared to serine phosphorylation?
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What is the main function of the extracellular domain in RTKs?
What is the main function of the extracellular domain in RTKs?
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Which of the following is NOT a function of the juxta-membrane domain in RTKs?
Which of the following is NOT a function of the juxta-membrane domain in RTKs?
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What is the result of ligand-mediated dimerisation of RTKs?
What is the result of ligand-mediated dimerisation of RTKs?
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Which of the following is an example of a growth factor that activates RTKs?
Which of the following is an example of a growth factor that activates RTKs?
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What is the purpose of the activation loop in RTK activation?
What is the purpose of the activation loop in RTK activation?
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What is the consequence of phosphorylating regulatory tyrosine residues in RTKs?
What is the consequence of phosphorylating regulatory tyrosine residues in RTKs?
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What is the primary function of the TK domain in tyrosine kinase-linked receptors?
What is the primary function of the TK domain in tyrosine kinase-linked receptors?
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What is the role of associated non-RTKs in the RTK activation paradigm?
What is the role of associated non-RTKs in the RTK activation paradigm?
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Which of the following is NOT a substrate of RTKs?
Which of the following is NOT a substrate of RTKs?
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What is the function of the PTB domain in RTK signaling?
What is the function of the PTB domain in RTK signaling?
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How do GF/cytokine receptors lacking intrinsic kinase domains become activated?
How do GF/cytokine receptors lacking intrinsic kinase domains become activated?
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What is the result of ligand binding in the RTK activation paradigm?
What is the result of ligand binding in the RTK activation paradigm?
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Which of the following best describes the role of kinases in receptor tyrosine kinases (RTKs)?
Which of the following best describes the role of kinases in receptor tyrosine kinases (RTKs)?
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Which of the following is NOT a characteristic of KINASE-LINKED RECEPTORS?
Which of the following is NOT a characteristic of KINASE-LINKED RECEPTORS?
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What is the functional difference between intrinsic and linked kinases in the context of kinase-linked receptors?
What is the functional difference between intrinsic and linked kinases in the context of kinase-linked receptors?
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Why are receptor tyrosine kinases currently the pharmaceutical industry's most popular drug target?
Why are receptor tyrosine kinases currently the pharmaceutical industry's most popular drug target?
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Which of the following processes does phosphorylation NOT regulate?
Which of the following processes does phosphorylation NOT regulate?
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How do multicellular organisms use cell-to-cell communication mechanisms?
How do multicellular organisms use cell-to-cell communication mechanisms?
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