18 Questions
What is the main function of GTP-binding proteins in protein activation and inactivation signalling mechanisms?
Regulate protein interactions by binding to GTP or GDP
Which of the following is NOT a main type of intracellular signalling complex?
Phosphorylation complex
What happens to a protein when it undergoes a conformational change in response to a biological signal?
It switches between active and inactive states
Which group of signalling interaction domains are commonly involved in protein-protein interactions that regulate cell signaling?
SH2 domains
Among the types of signal transduction proteins, which type typically function as enzymes that catalyze phosphorylation reactions?
Kinases
What determines the duration of a protein's active state in an intracellular signalling pathway?
Dephosphorylation
What defines the signalling function of signal transduction proteins?
Presence of catalytic activity
Which type of signal transduction proteins possess intrinsic enzyme activity?
Enzymes
What distinguishes adaptor proteins from enzymes in signal transduction?
Intrinsic enzyme activity
Which type of proteins contain unique DNA-binding domains among signal transduction proteins?
Gene regulatory proteins
What type of domain do gene regulatory proteins contain that is distinctive among signal transduction proteins?
DNA-binding domain
Which type of signal transduction protein possesses modular signalling domains but lacks intrinsic enzyme activity?
Adaptor proteins
What is the main function of protein kinases in intracellular signalling pathways?
Add phosphate group to activate intracellular signalling protein
Which type of proteins relay messages from G-protein coupled receptors?
Large trimeric GTP-binding proteins
What is the main function of protein phosphatases in cell signalling?
Remove phosphate group to deactivate intracellular signalling protein
Which mechanism can shut off intracellular signalling proteins by hydrolysing bound GTP to GDP?
GTPase cycle
Which type of proteins are often organized into phosphorylation cascades in cell signalling pathways?
Serine/Threonine Kinases
What are the two main types of interactions involved in the transduction of signals in intracellular signalling complexes?
Protein-2nd Messengers, Protein-Protein
Test your knowledge on the different types of signaling transduction proteins and their interactions between signaling domains and recognition motifs. Learn how these proteins relay signals downstream in the cell.
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