Podcast
Questions and Answers
Which of the following is NOT a general model of intracellular signaling discussed in the text?
Which of the following is NOT a general model of intracellular signaling discussed in the text?
- G-proteins
- Desensitization and adaptation
- Ionic and gaseous lipids (correct)
- Signal amplification
What is the key function of receptors in the cell membrane?
What is the key function of receptors in the cell membrane?
- Detecting intracellular signals
- Accumulating 2nd messengers
- Transforming extracellular signals into intracellular signals (correct)
- Modifying cell function
Where do some 2nd messengers accumulate in the cell?
Where do some 2nd messengers accumulate in the cell?
- In the cytoplasm (correct)
- In the nucleus
- In the mitochondria
- In the endoplasmic reticulum
Which of the following is NOT a function of the cell membrane in intracellular signaling?
Which of the following is NOT a function of the cell membrane in intracellular signaling?
What happens in an inactive intracellular signaling system?
What happens in an inactive intracellular signaling system?
What happens in an active intracellular signaling system?
What happens in an active intracellular signaling system?
According to the text, where can more detailed explorations of cell biology be found?
According to the text, where can more detailed explorations of cell biology be found?
Which enzyme is responsible for the conversion of ATP to cAMP?
Which enzyme is responsible for the conversion of ATP to cAMP?
Which enzyme is responsible for the conversion of cAMP to 5'-AMP?
Which enzyme is responsible for the conversion of cAMP to 5'-AMP?
Which G-protein mechanism stimulates adenylyl cyclase and increases cAMP production?
Which G-protein mechanism stimulates adenylyl cyclase and increases cAMP production?
Which G-protein mechanism inhibits adenylyl cyclase and decreases cAMP production?
Which G-protein mechanism inhibits adenylyl cyclase and decreases cAMP production?
What is the role of IP3 in the Gq GPCR signaling pathway?
What is the role of IP3 in the Gq GPCR signaling pathway?
What is the function of calmodulin in the Gq GPCR signaling pathway?
What is the function of calmodulin in the Gq GPCR signaling pathway?
What is the unique feature of the Gq GPCR signaling pathway compared to other G-protein mechanisms?
What is the unique feature of the Gq GPCR signaling pathway compared to other G-protein mechanisms?
Which of the following is true about G-protein coupled receptors (GPCRs)?
Which of the following is true about G-protein coupled receptors (GPCRs)?
What happens when a ligand binds to a receptor associated with a Gs G-protein?
What happens when a ligand binds to a receptor associated with a Gs G-protein?
What is the role of adenylyl cyclase in GPCR signaling?
What is the role of adenylyl cyclase in GPCR signaling?
What happens when cAMP binds to protein kinase A (PKA)?
What happens when cAMP binds to protein kinase A (PKA)?
What happens when the alpha subunit of a G-protein hydrolyzes GTP?
What happens when the alpha subunit of a G-protein hydrolyzes GTP?
What is the role of the beta-gamma subunit in GPCR signaling?
What is the role of the beta-gamma subunit in GPCR signaling?
What is the main function of GPCRs in intracellular signaling?
What is the main function of GPCRs in intracellular signaling?
Which molecule can modulate the activity of many other effectors?
Which molecule can modulate the activity of many other effectors?
What is the Nernst potential for K+?
What is the Nernst potential for K+?
What is the effect of opening a channel that allows sodium to enter the cell?
What is the effect of opening a channel that allows sodium to enter the cell?
What is the effect of opening a channel that allows more potassium to leave the cell?
What is the effect of opening a channel that allows more potassium to leave the cell?
What is the effect of opening a channel that allows calcium to enter the cytosol?
What is the effect of opening a channel that allows calcium to enter the cytosol?
What is the cytosolic calcium concentration compared to the extracellular calcium concentration at rest?
What is the cytosolic calcium concentration compared to the extracellular calcium concentration at rest?
What is the role of Gi-α inactivating adenylyl cyclase?
What is the role of Gi-α inactivating adenylyl cyclase?
What is the role of Gi-βγ?
What is the role of Gi-βγ?
What is the role of the Na+/K+-ATPase and K+ channels in the cell membrane?
What is the role of the Na+/K+-ATPase and K+ channels in the cell membrane?
Which class of receptors has intrinsic enzyme activity?
Which class of receptors has intrinsic enzyme activity?
What happens when a ligand binds to a receptor associated with a RTK?
What happens when a ligand binds to a receptor associated with a RTK?
What is the main function of RTKs in intracellular signaling?
What is the main function of RTKs in intracellular signaling?
Which signaling pathway involves the activation of phospholipase C?
Which signaling pathway involves the activation of phospholipase C?
What is the role of Ras in the Ras cascade signaling pathway?
What is the role of Ras in the Ras cascade signaling pathway?
Which ligand is NOT an example of a ligand that binds to RTKs?
Which ligand is NOT an example of a ligand that binds to RTKs?
What happens when a ligand binds to a receptor monomer associated with an RTK?
What happens when a ligand binds to a receptor monomer associated with an RTK?
Which G-protein mechanism inhibits adenylyl cyclase and decreases cAMP production?
Which G-protein mechanism inhibits adenylyl cyclase and decreases cAMP production?
What is the role of the beta-gamma subunit in GPCR signaling?
What is the role of the beta-gamma subunit in GPCR signaling?
What is the effect of opening a channel that allows calcium to enter the cytosol?
What is the effect of opening a channel that allows calcium to enter the cytosol?
Which of the following is the key pathway for many growth factors?
Which of the following is the key pathway for many growth factors?
What is the role of PIP3 in the PI3K-Akt pathway?
What is the role of PIP3 in the PI3K-Akt pathway?
What is the function of Akt in the PI3K-Akt pathway?
What is the function of Akt in the PI3K-Akt pathway?
Which molecule is produced from GTP by guanylyl cyclase in the nitric oxide-mediated pathway?
Which molecule is produced from GTP by guanylyl cyclase in the nitric oxide-mediated pathway?
What is the effect of elevated cytosolic cGMP in the nitric oxide-mediated pathway?
What is the effect of elevated cytosolic cGMP in the nitric oxide-mediated pathway?
What is the role of nitric oxide synthase (NOs) in the nitric oxide-mediated pathway?
What is the role of nitric oxide synthase (NOs) in the nitric oxide-mediated pathway?
Which of the following is NOT a characteristic of nitric oxide (NO)?
Which of the following is NOT a characteristic of nitric oxide (NO)?
What is the role of Ras in the Ras-Raf-MAP kinase pathway?
What is the role of Ras in the Ras-Raf-MAP kinase pathway?
What is the unique signaling mechanism of the PI3K-Akt pathway?
What is the unique signaling mechanism of the PI3K-Akt pathway?
What is the role of PDK1 in the PI3K-Akt pathway?
What is the role of PDK1 in the PI3K-Akt pathway?
