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Questions and Answers
Which gene is responsible for sickle cell anaemia?
Which gene is responsible for sickle cell anaemia?
- HbA
- HbS (correct)
- HbSHbS
- HbAHbS
What is the shape of the red blood cells in sickle cell anaemia?
What is the shape of the red blood cells in sickle cell anaemia?
- Circular
- Spherical
- C-shaped (correct)
- Triangular
Why do the misshapen blood cells in sickle cell anaemia not transport oxygen effectively?
Why do the misshapen blood cells in sickle cell anaemia not transport oxygen effectively?
- They cannot pass through small blood vessels (correct)
- They clump together and form blockages
- They are too large to pass through small blood vessels
- They cannot bind to oxygen molecules
What is the allele for normal haemoglobin?
What is the allele for normal haemoglobin?
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What is the term for individuals who have both normal and sickle red blood cells?
What is the term for individuals who have both normal and sickle red blood cells?
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Study Notes
Sickle Cell Anaemia
- The gene responsible for sickle cell anaemia is HBB (haemoglobin subunit beta).
Red Blood Cells
- In sickle cell anaemia, red blood cells are misshapen and crescent-shaped, rather than the normal disc shape.
Oxygen Transport
- The misshapen cells in sickle cell anaemia do not transport oxygen effectively because they get stuck in small blood vessels, blocking oxygen delivery to tissues and organs.
Haemoglobin Alleles
- The allele for normal haemoglobin is HbA (haemoglobin A).
Genetic Status
- Individuals who have both normal and sickle red blood cells are known as carriers or have sickle cell trait.
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