Shingles and Varicella-Zoster Virus

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Questions and Answers

What causes shingles in individuals with a history of chickenpox?

  • Reactivation of the varicella-zoster virus (correct)
  • Initial infection with the varicella-zoster virus
  • Reinfection with chickenpox
  • Reactivation of the herpes simplex virus

Where does the dormant varicella-zoster virus reside in the body?

  • In the lymph nodes
  • In the dorsal nerve root ganglia (correct)
  • In the bloodstream
  • In the muscle tissues

Which method is NOT used for diagnosing shingles?

  • Tzanck smear
  • Blood culture (correct)
  • Visual examination
  • Viral culture

Who is at risk of contracting herpes zoster?

<p>Individuals who had no prior exposure to chickenpox (C)</p> Signup and view all the answers

What is a common symptom that may persist after herpes zoster lesions resolve?

<p>Severe pain known as postherpetic neuralgia (D)</p> Signup and view all the answers

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Study Notes

Shingles Overview

  • Shingles results from the reactivation of the varicella-zoster virus in individuals with a history of chickenpox.
  • Occurs during immunocompromised states, indicating a link between immune health and the likelihood of developing shingles.

Virus Dormancy

  • The varicella-zoster virus remains dormant in the dorsal nerve root ganglia of sensory cranial and spinal nerves after initial chickenpox infection.

Symptoms and Presentation

  • Herpes zoster manifests as painful eruptions in a segmental distribution along the skin area corresponding to the infected nerve, typically appearing after days of discomfort.

Diagnosis

  • Diagnosis involves visual examination, Tzanck smear to confirm herpes infection, and viral culture to identify the specific virus involved.

Postherpetic Neuralgia

  • After lesions heal, patients may continue to experience postherpetic neuralgia, characterized by severe pain in the affected area.

Contagion

  • Shingles is contagious to those who have never had chickenpox or have not been vaccinated, highlighting the importance of vaccination in preventing outbreaks.
  • Herpes simplex virus (HSV) includes type 1, mainly causing cold sores (usually on the lip), and type 2, linked to genital herpes, typically below the waist; both types are contagious and can co-occur.

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