10 Questions
What is the product of the reaction between PEP and shikimic acid 3-phosphate?
3-Enolpyruvylshikimic acid 3-phosphate
Which enzyme is responsible for catalyzing the reaction between PEP and shikimic acid 3-phosphate?
EPSP synthase
What is the outcome of a plant's inability to synthesize aromatic amino acids?
Death of the plant
What is the mechanism by which EPSP is transformed into chorismic acid?
Elimination of the phosphate group
What is believed to be the binding site of glyphosate on the enzyme EPSP synthase?
PEP binding site
What is the function of EPSP synthase?
To catalyze the reaction between PEP and shikimic acid 3-phosphate
What is the effect of glyphosate on plants?
It inhibits the synthesis of aromatic amino acids, leading to plant death
What is the intermediate compound formed in the reaction between PEP and shikimic acid 3-phosphate?
3-enolpyruvylshikimic acid 3-phosphate (EPSP)
What is the result of the elimination of the phosphate group from EPSP?
Formation of chorismic acid
What is the type of reaction that forms EPSP from PEP and shikimic acid 3-phosphate?
Addition-elimination reaction
Study Notes
Shikimate Pathway
- Chorismic acid is an important branch-point compound in the shikimate pathway
- Shikimic acid 3-phosphate is produced through an ATP-dependent phosphorylation reaction
- PEP combines with shikimic acid 3-phosphate to form 3-enolpyruvylshikimate 3-phosphate (EPSP) through an addition-elimination reaction
- This reaction is catalyzed by the enzyme EPSP synthase
EPSP Synthase and Chorismic Acid
- EPSP is converted to chorismic acid after elimination of the phosphate group
- EPSP synthase is inhibited by the synthetic compound N-(phosphonomethyl)glycine derivative glyphosate
- Glyphosate binds to the PEP binding site on the enzyme EPSP synthase
Glyphosate and Its Effects
- Glyphosate is a broad-spectrum herbicide used extensively
- It causes plants to die by inhibiting their ability to synthesize aromatic amino acids
Shikimate Pathway
- Chorismic acid is an important branch-point compound in the shikimate pathway
- Shikimic acid 3-phosphate is produced through an ATP-dependent phosphorylation reaction
- PEP combines with shikimic acid 3-phosphate to form 3-enolpyruvylshikimate 3-phosphate (EPSP) through an addition-elimination reaction
- This reaction is catalyzed by the enzyme EPSP synthase
EPSP Synthase and Chorismic Acid
- EPSP is converted to chorismic acid after elimination of the phosphate group
- EPSP synthase is inhibited by the synthetic compound N-(phosphonomethyl)glycine derivative glyphosate
- Glyphosate binds to the PEP binding site on the enzyme EPSP synthase
Glyphosate and Its Effects
- Glyphosate is a broad-spectrum herbicide used extensively
- It causes plants to die by inhibiting their ability to synthesize aromatic amino acids
This quiz covers the synthesis of chorismic acid in the shikimate pathway, including the reaction of PEP and shikimic acid 3-phosphate, catalyzed by EPSP synthase. Learn about the formation of EPSP and its transformation into chorismic acid.
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