Podcast
Questions and Answers
What is the product of the reaction between PEP and shikimic acid 3-phosphate?
What is the product of the reaction between PEP and shikimic acid 3-phosphate?
Which enzyme is responsible for catalyzing the reaction between PEP and shikimic acid 3-phosphate?
Which enzyme is responsible for catalyzing the reaction between PEP and shikimic acid 3-phosphate?
What is the outcome of a plant's inability to synthesize aromatic amino acids?
What is the outcome of a plant's inability to synthesize aromatic amino acids?
What is the mechanism by which EPSP is transformed into chorismic acid?
What is the mechanism by which EPSP is transformed into chorismic acid?
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What is believed to be the binding site of glyphosate on the enzyme EPSP synthase?
What is believed to be the binding site of glyphosate on the enzyme EPSP synthase?
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What is the function of EPSP synthase?
What is the function of EPSP synthase?
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What is the effect of glyphosate on plants?
What is the effect of glyphosate on plants?
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What is the intermediate compound formed in the reaction between PEP and shikimic acid 3-phosphate?
What is the intermediate compound formed in the reaction between PEP and shikimic acid 3-phosphate?
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What is the result of the elimination of the phosphate group from EPSP?
What is the result of the elimination of the phosphate group from EPSP?
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What is the type of reaction that forms EPSP from PEP and shikimic acid 3-phosphate?
What is the type of reaction that forms EPSP from PEP and shikimic acid 3-phosphate?
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Study Notes
Shikimate Pathway
- Chorismic acid is an important branch-point compound in the shikimate pathway
- Shikimic acid 3-phosphate is produced through an ATP-dependent phosphorylation reaction
- PEP combines with shikimic acid 3-phosphate to form 3-enolpyruvylshikimate 3-phosphate (EPSP) through an addition-elimination reaction
- This reaction is catalyzed by the enzyme EPSP synthase
EPSP Synthase and Chorismic Acid
- EPSP is converted to chorismic acid after elimination of the phosphate group
- EPSP synthase is inhibited by the synthetic compound N-(phosphonomethyl)glycine derivative glyphosate
- Glyphosate binds to the PEP binding site on the enzyme EPSP synthase
Glyphosate and Its Effects
- Glyphosate is a broad-spectrum herbicide used extensively
- It causes plants to die by inhibiting their ability to synthesize aromatic amino acids
Shikimate Pathway
- Chorismic acid is an important branch-point compound in the shikimate pathway
- Shikimic acid 3-phosphate is produced through an ATP-dependent phosphorylation reaction
- PEP combines with shikimic acid 3-phosphate to form 3-enolpyruvylshikimate 3-phosphate (EPSP) through an addition-elimination reaction
- This reaction is catalyzed by the enzyme EPSP synthase
EPSP Synthase and Chorismic Acid
- EPSP is converted to chorismic acid after elimination of the phosphate group
- EPSP synthase is inhibited by the synthetic compound N-(phosphonomethyl)glycine derivative glyphosate
- Glyphosate binds to the PEP binding site on the enzyme EPSP synthase
Glyphosate and Its Effects
- Glyphosate is a broad-spectrum herbicide used extensively
- It causes plants to die by inhibiting their ability to synthesize aromatic amino acids
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Description
This quiz covers the synthesis of chorismic acid in the shikimate pathway, including the reaction of PEP and shikimic acid 3-phosphate, catalyzed by EPSP synthase. Learn about the formation of EPSP and its transformation into chorismic acid.
