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Questions and Answers
What is the typical time needed to reach maximum plasma concentration for both venlafaxine and duloxetine?
What is the typical time needed to reach maximum plasma concentration for both venlafaxine and duloxetine?
- 2 hours (correct)
- 3 hours
- 1 hour
- 4 hours
What is the approximate bioavailability of orally administered desvenlafaxine?
What is the approximate bioavailability of orally administered desvenlafaxine?
- 95%
- 50%
- 80% (correct)
- 65%
Which of the following SNRIs is metabolized primarily by CYP3A4?
Which of the following SNRIs is metabolized primarily by CYP3A4?
- Venlafaxine
- Duloxetine
- Milnacipran
- Levomilnacipran (correct)
What percentage of milnacipran is excreted unchanged in the urine?
What percentage of milnacipran is excreted unchanged in the urine?
Which SNRI has the longest half-life?
Which SNRI has the longest half-life?
Which SNRI has the highest protein binding?
Which SNRI has the highest protein binding?
Which SNRI is metabolized by both CYP2D6 and CYP1A2?
Which SNRI is metabolized by both CYP2D6 and CYP1A2?
What is the typical bioavailability of orally administered levomilnacipran?
What is the typical bioavailability of orally administered levomilnacipran?
Which SNRI is excreted mostly unchanged in the urine?
Which SNRI is excreted mostly unchanged in the urine?
Which SNRI has been found in breast milk?
Which SNRI has been found in breast milk?
What is the recommended initial dosage for desvenlafaxine in the treatment of major depressive disorder (MDD)?
What is the recommended initial dosage for desvenlafaxine in the treatment of major depressive disorder (MDD)?
If a patient does not respond to the initial dosage of desvenlafaxine after 6 weeks, what is the recommended course of action?
If a patient does not respond to the initial dosage of desvenlafaxine after 6 weeks, what is the recommended course of action?
Which of the following statements about duloxetine is true?
Which of the following statements about duloxetine is true?
Which of the following statements about venlafaxine is true?
Which of the following statements about venlafaxine is true?
What is the primary indication for milnacipran?
What is the primary indication for milnacipran?
Which of the following statements regarding patient education for serotonin-norepinephrine reuptake inhibitors (SNRIs) is true?
Which of the following statements regarding patient education for serotonin-norepinephrine reuptake inhibitors (SNRIs) is true?
What was the most common adverse effect of milnacipran reported in clinical trials?
What was the most common adverse effect of milnacipran reported in clinical trials?
Which of the following drugs may require an adjustment of levomilnacipran dosage due to a potential drug interaction?
Which of the following drugs may require an adjustment of levomilnacipran dosage due to a potential drug interaction?
What is the recommended initial dose of duloxetine for treating major depressive disorder?
What is the recommended initial dose of duloxetine for treating major depressive disorder?
Which of the following adverse effects is commonly reported by male patients taking milnacipran?
Which of the following adverse effects is commonly reported by male patients taking milnacipran?
What is the maximum recommended daily dose of levomilnacipran for the treatment of major depressive disorder?
What is the maximum recommended daily dose of levomilnacipran for the treatment of major depressive disorder?
Which of the following drugs may cause serotonin syndrome if used concurrently with milnacipran?
Which of the following drugs may cause serotonin syndrome if used concurrently with milnacipran?
What is the recommended dose of milnacipran for the treatment of fibromyalgia?
What is the recommended dose of milnacipran for the treatment of fibromyalgia?
Which of the following drugs may interact with venlafaxine by inhibiting the CYP2D6 enzyme?
Which of the following drugs may interact with venlafaxine by inhibiting the CYP2D6 enzyme?
Which of the following adverse effects is commonly associated with levomilnacipran?
Which of the following adverse effects is commonly associated with levomilnacipran?
What is the recommended initial dose of venlafaxine XR for treating major depressive disorder?
What is the recommended initial dose of venlafaxine XR for treating major depressive disorder?
Which SNRI was approved by the FDA to treat fibromyalgia?
Which SNRI was approved by the FDA to treat fibromyalgia?
Which SNRI has a Black Box Warning related to liver toxicity?
Which SNRI has a Black Box Warning related to liver toxicity?
At what year was levomilnacipran (Fetzima) approved for Major Depressive Disorder (MDD)?
At what year was levomilnacipran (Fetzima) approved for Major Depressive Disorder (MDD)?
Which SNRI predominantly affects serotonin reuptake at lower doses?
Which SNRI predominantly affects serotonin reuptake at lower doses?
What is the main mechanism of action of venlafaxine, duloxetine, and desvenlafaxine as SNRIs?
What is the main mechanism of action of venlafaxine, duloxetine, and desvenlafaxine as SNRIs?
Which SNRI is considered a more potent and equal serotonin and norepinephrine reuptake inhibitor than venlafaxine?
Which SNRI is considered a more potent and equal serotonin and norepinephrine reuptake inhibitor than venlafaxine?
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