Podcast
Questions and Answers
Which statement about the mechanism of action of SNRIs is correct?
Which statement about the mechanism of action of SNRIs is correct?
- SNRIs inhibit the synthesis of both norepinephrine and serotonin in the presynaptic neuron.
- SNRIs selectively block the reuptake of serotonin into the presynaptic nerve terminal.
- SNRIs cause enhanced noradrenergic neurotransmission but have no effect on serotonergic neurotransmission.
- SNRIs block the reuptake of both norepinephrine (NE) and serotonin (5-HT) into the presynaptic nerve terminal. (correct)
Which of the following SNRIs has high protein binding?
Which of the following SNRIs has high protein binding?
- Venlafaxine
- Desvenlafaxine
- Duloxetine (correct)
- Levomilnacipran
Which of the following adverse effects is commonly associated with lithium therapy?
Which of the following adverse effects is commonly associated with lithium therapy?
- Tardive dyskinesia
- Postural hand tremor (correct)
- Akathisia
- Agranulocytosis
Which of the following EKG changes is associated with lithium toxicity?
Which of the following EKG changes is associated with lithium toxicity?
Which of the following statements about lithium-induced nephrogenic diabetes insipidus is correct?
Which of the following statements about lithium-induced nephrogenic diabetes insipidus is correct?
Which of the following statements about the pharmacokinetics of SNRIs is correct?
Which of the following statements about the pharmacokinetics of SNRIs is correct?
Which of the following is the MOST important consideration when transitioning a patient from an SSRI to an MAOI?
Which of the following is the MOST important consideration when transitioning a patient from an SSRI to an MAOI?
Which SSRI is considered the most potent inhibitor of the CYP450 enzyme system?
Which SSRI is considered the most potent inhibitor of the CYP450 enzyme system?
Which of the following best describes the metabolism of fluoxetine (Prozac)?
Which of the following best describes the metabolism of fluoxetine (Prozac)?
Which CYP450 enzyme is primarily involved in the metabolism of most SSRIs?
Which CYP450 enzyme is primarily involved in the metabolism of most SSRIs?
What is the MOST important drug interaction to consider when prescribing an SSRI concurrently with a monoamine oxidase inhibitor (MAOI)?
What is the MOST important drug interaction to consider when prescribing an SSRI concurrently with a monoamine oxidase inhibitor (MAOI)?
Which SSRI has the LOWEST risk of causing serotonin discontinuation syndrome when abruptly discontinued?
Which SSRI has the LOWEST risk of causing serotonin discontinuation syndrome when abruptly discontinued?
Which of the following drugs, when combined with an SSRI, can increase the risk of serotonin syndrome?
Which of the following drugs, when combined with an SSRI, can increase the risk of serotonin syndrome?
Which SSRI is the LEAST likely to cause anticholinergic adverse effects like dry mouth?
Which SSRI is the LEAST likely to cause anticholinergic adverse effects like dry mouth?
Which SNRI has a slightly higher incidence of anticholinergic side effects compared to other SNRIs?
Which SNRI has a slightly higher incidence of anticholinergic side effects compared to other SNRIs?
Which of the following is the MOST important adverse effect to monitor for when a patient is taking an SSRI and an antiplatelet or anticoagulant medication concurrently?
Which of the following is the MOST important adverse effect to monitor for when a patient is taking an SSRI and an antiplatelet or anticoagulant medication concurrently?
What response should be anticipated when giving a direct-acting or indirect-acting sympathomimetic to a patient recently started on a tricyclic antidepressant (TCA)?
What response should be anticipated when giving a direct-acting or indirect-acting sympathomimetic to a patient recently started on a tricyclic antidepressant (TCA)?
Why are smaller than usual doses of direct-acting sympathomimetics recommended when co-administered with TCAs?
Why are smaller than usual doses of direct-acting sympathomimetics recommended when co-administered with TCAs?
In patients chronically treated with TCAs, why may conventional sympathomimetics be ineffective in restoring systemic blood pressure?
In patients chronically treated with TCAs, why may conventional sympathomimetics be ineffective in restoring systemic blood pressure?
How should the initial dose of a sympathomimetic be adjusted in patients on TCA therapy for more than 6 weeks?
How should the initial dose of a sympathomimetic be adjusted in patients on TCA therapy for more than 6 weeks?
Why may patients on TCA therapy exhibit complex and unpredictable systemic blood pressure effects when administered sympathomimetics?
Why may patients on TCA therapy exhibit complex and unpredictable systemic blood pressure effects when administered sympathomimetics?
What is a potential consequence of administering a direct-acting or indirect-acting sympathomimetic to a patient recently started on a tricyclic antidepressant (TCA)?
What is a potential consequence of administering a direct-acting or indirect-acting sympathomimetic to a patient recently started on a tricyclic antidepressant (TCA)?
Why are smaller than usual doses of direct-acting sympathomimetics recommended when co-administered with TCAs?
Why are smaller than usual doses of direct-acting sympathomimetics recommended when co-administered with TCAs?
Which enzyme is primarily involved in the metabolism of most SSRIs?
Which enzyme is primarily involved in the metabolism of most SSRIs?
What response should be expected when giving a conventional sympathomimetic to a patient chronically treated with TCAs?
What response should be expected when giving a conventional sympathomimetic to a patient chronically treated with TCAs?
Which of the following is a potential consequence of administering a direct-acting or indirect-acting sympathomimetic to a patient recently started on a TCA?
Which of the following is a potential consequence of administering a direct-acting or indirect-acting sympathomimetic to a patient recently started on a TCA?
Which SNRI has the highest incidence of anticholinergic side effects compared to other SNRIs?
Which SNRI has the highest incidence of anticholinergic side effects compared to other SNRIs?
What happens to adrenergic receptors in patients chronically treated with TCAs?
What happens to adrenergic receptors in patients chronically treated with TCAs?
Which of the following is the MOST important drug interaction to consider when prescribing an SSRI concurrently with a monoamine oxidase inhibitor (MAOI)?
Which of the following is the MOST important drug interaction to consider when prescribing an SSRI concurrently with a monoamine oxidase inhibitor (MAOI)?
Which SSRI is considered the MOST potent inhibitor of the CYP450 enzyme system?
Which SSRI is considered the MOST potent inhibitor of the CYP450 enzyme system?
Which of the following best describes the metabolism of fluoxetine (Prozac)?
Which of the following best describes the metabolism of fluoxetine (Prozac)?
Which of the following drugs, when combined with an SSRI, can increase the risk of serotonin syndrome?
Which of the following drugs, when combined with an SSRI, can increase the risk of serotonin syndrome?
Which of the following is a potential consequence of administering a direct-acting or indirect-acting sympathomimetic to a patient recently started on a tricyclic antidepressant (TCA)?
Which of the following is a potential consequence of administering a direct-acting or indirect-acting sympathomimetic to a patient recently started on a tricyclic antidepressant (TCA)?
Which of the following is the LEAST likely to cause anticholinergic adverse effects like dry mouth when compared to other SSRIs?
Which of the following is the LEAST likely to cause anticholinergic adverse effects like dry mouth when compared to other SSRIs?
Which of the following statements regarding the interaction between SSRIs and monoamine oxidase inhibitors (MAOIs) is correct?
Which of the following statements regarding the interaction between SSRIs and monoamine oxidase inhibitors (MAOIs) is correct?
Which of the following statements regarding CYP2D6 inhibition by SSRIs is correct?
Which of the following statements regarding CYP2D6 inhibition by SSRIs is correct?
Which of the following statements regarding the metabolism of SSRIs is correct?
Which of the following statements regarding the metabolism of SSRIs is correct?
Which of the following SSRIs is considered the most potent inhibitor of the CYP450 enzyme system?
Which of the following SSRIs is considered the most potent inhibitor of the CYP450 enzyme system?
Which of the following drugs, when combined with an SSRI, can increase the risk of serotonin syndrome?
Which of the following drugs, when combined with an SSRI, can increase the risk of serotonin syndrome?
Which of the following statements regarding the interaction between SSRIs and antiplatelet or anticoagulant agents is correct?
Which of the following statements regarding the interaction between SSRIs and antiplatelet or anticoagulant agents is correct?
Which of the following statements regarding the metabolism of fluoxetine (Prozac) is correct?
Which of the following statements regarding the metabolism of fluoxetine (Prozac) is correct?
Which of the following drugs, when combined with an SSRI, can increase the risk of serotonin syndrome?
Which of the following drugs, when combined with an SSRI, can increase the risk of serotonin syndrome?
Which of the following statements regarding the interaction between SSRIs and CYP2D6 inhibitors is correct?
Which of the following statements regarding the interaction between SSRIs and CYP2D6 inhibitors is correct?
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