Sepsis and Septic Shock

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Questions and Answers

Which statement best describes the underlying mechanism of sepsis?

  • A dysregulated host response to infection, causing widespread inflammation and tissue damage. (correct)
  • A localized immune response that damages the infected tissue.
  • A regulated immune response to infection, directly targeting the pathogen.
  • A suppressed immune response to infection, leading to opportunistic infections.

Septic shock is characterized by persistent hypotension requiring vasopressors and a serum lactate level above what value?

  • 1 mmol/L
  • 4 mmol/L
  • 3 mmol/L
  • 2 mmol/L (correct)

Which vessel provides the majority of blood flow to the liver, and what is the primary characteristic of this blood?

  • Hepatic artery; oxygen-rich
  • Hepatic vein; oxygen-poor
  • Hepatic portal vein; nutrient-rich, oxygen-poor (correct)
  • Hepatic artery; nutrient-poor, oxygen-rich

The hepatic artery supplies what percentage of blood to the liver?

<p>25% (D)</p> Signup and view all the answers

A patient has burns on their entire left arm and the front of their trunk. Using the Rule of Nines, what is the estimated percentage of total body surface area (TBSA) burned?

<p>27% (A)</p> Signup and view all the answers

Which burn estimation method relies on comparing the patient's palm surface area to the burned area?

<p>Palmar surface method (D)</p> Signup and view all the answers

What is a key difference between the Lund-Browder chart and the Rule of Nines in estimating burn area?

<p>The Lund-Browder chart adjusts for age-related changes in body surface area. (C)</p> Signup and view all the answers

Why is the Surface Area Graphic Evaluation (SAGE) method considered advantageous in burn area estimation?

<p>It uses digital imaging for potentially more accurate burn size assessment. (D)</p> Signup and view all the answers

Which of the following statements accurately differentiates disinfection from sterilization?

<p>Disinfection selectively eliminates some unwanted microorganisms, while sterilization destroys all microorganisms and spores. (D)</p> Signup and view all the answers

A hospital uses a chemical agent to clean a surface, aiming to reduce the number of pathogenic organisms to a safe level. This process is best described as:

<p>Disinfection (C)</p> Signup and view all the answers

What is the critical distinction between disinfection and antisepsis?

<p>Disinfection is used on inanimate objects, while antisepsis is used on living tissue. (A)</p> Signup and view all the answers

Why is sterilization considered a more rigorous process than disinfection in healthcare settings?

<p>Sterilization eliminates all forms of microbial life, including spores. (A)</p> Signup and view all the answers

The cystic duct directly connects which two anatomical structures?

<p>Gallbladder and common bile duct (D)</p> Signup and view all the answers

Where does the bile, after exiting the cystic duct, ultimately drain into?

<p>Duodenum (B)</p> Signup and view all the answers

What is the functional consequence of the cystic duct merging with the common hepatic duct?

<p>Formation of the common bile duct (D)</p> Signup and view all the answers

What is the primary role of the common bile duct (CBD)?

<p>To transport bile from the gallbladder and liver to the duodenum (C)</p> Signup and view all the answers

If the cystic duct is blocked by a gallstone, which of the following would likely occur?

<p>Impaired bile storage and potential gallbladder inflammation (B)</p> Signup and view all the answers

What type of blood does the hepatic portal vein carry, and where does it originate?

<p>Nutrient-rich blood from the small intestines. (C)</p> Signup and view all the answers

What is a key difference between the blood supplied by the hepatic artery and the hepatic portal vein?

<p>The hepatic artery supplies oxygenated blood while the portal vein supplies deoxygenated blood. (D)</p> Signup and view all the answers

What primarily happens to the blood (from the hepatic portal vein) within the liver?

<p>It is filtered and processed to remove nutrients, toxins and other unwanted agents. (C)</p> Signup and view all the answers

Flashcards

Sepsis

Life-threatening condition; dysregulated host response to infection. Widespread inflammation causes tissue and organ damage

Septic Shock

Severe sepsis stage; vasodilatory/distributive shock. Requires vasopressors (MAP >= 65mmHg) and lactate > 2 mmol/L.

Hepatic Portal Vein

Supplies ~75% of liver blood. Nutrient-rich, oxygen-poor blood from the small intestine.

Hepatic Artery

Supplies ~25% of liver blood. Oxygen-rich blood directly from the abdominal aorta.

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Burn Area Estimation Techniques

Estimates burn area: Rule of nines Palmar surface method Lund and Browder chart Surface area graphic evaluation (SAGE)

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Disinfection: Complete Microorganism Removal?

No, it selectively eliminates microorganisms acting on their structure or metabolism.

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Cystic Duct Drainage

Cystic duct drains into the common hepatic duct to form the common bile duct (CBD), which then drains into the duodenum.

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Study Notes

  • Sepsis is a life-threatening condition arising from a dysregulated host response to infection.
  • This dysregulation leads to widespread inflammation, causing tissue and organ damage.
  • Septic shock is the most critical stage of sepsis, characterized as a vasodilatory/distributive shock.
  • Septic shock has a higher mortality risk than sepsis.
  • Septic shock is defined by persistent hypotension requiring vasopressors.
  • Vasopressors are needed to maintain a Mean Arterial Pressure (MAP) of >= 65mmHg.
  • Septic shock also involves a serum lactate level of > 2 mmol/L.
  • The hepatic portal vein delivers approximately 75% of the liver's blood supply.
  • Blood from the hepatic portal vein is rich in nutrients absorbed from the small intestines.
  • This blood is mostly oxygen-poor due to oxygen consumption in the small intestine.
  • The hepatic artery provides the remaining 25% of blood to the liver.
  • Blood from the hepatic artery is oxygen-rich, coming directly from the abdominal aorta.
  • Techniques to evaluate burn area include:
    • Rule of nines
    • Palmar surface method
    • Lund and Browder chart
    • Surface Area Graphic Evaluation (SAGE)
  • Disinfection does not eliminate all microorganisms, but it selectively eliminates some unwanted ones.
  • Disinfection targets the structure or metabolism of microorganisms to prevent their transmission.
  • Sterilization is a process that destroys all microorganisms, including intra-organisms and spores.
  • The cystic duct drains into the common hepatic duct.
  • The cystic duct and the common hepatic duct merge to form the common bile duct (CBD).
  • Bile from the gallbladder drains through the cystic duct into the common hepatic duct.
  • The liver also contributes bile to the common hepatic duct.
  • Bile from both the gallbladder and liver flows through the common bile duct into the duodenum.

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