ILAE

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Questions and Answers

Which of the following indicates a type of seizure with a specific origin?

  • Unknown onset
  • Systemic onset
  • Generalized onset
  • Focal onset (correct)

What is the main purpose of classifying the epilepsies?

  • For clinical diagnosis (correct)
  • To determine the severity of seizures
  • To identify all types of neurological disorders
  • To find the best treatment option

Which of the following is not a category of etiology for epilepsy?

  • Structural
  • Functional (correct)
  • Genetic
  • Infectious

Which scenario allows for the maximum level of diagnosis in epilepsy classification?

<p>When information is minimal leading to seizure type classification (A)</p> Signup and view all the answers

Which of the following correctly describes unknown onset seizures?

<p>Seizures whose onset cannot be classified as focal or generalized (A)</p> Signup and view all the answers

What is a characteristic feature of focal seizures?

<p>They originate from a specific area of the brain (B)</p> Signup and view all the answers

Which of the following comorbidities is associated with epilepsy classification?

<p>Mood disorders (C)</p> Signup and view all the answers

Which combination describes an epilepsy type that includes both generalized and focal seizures?

<p>Combined epilepsies (D)</p> Signup and view all the answers

What distinguishes Developmental and/or Epileptic Encephalopathies from other types of epilepsy in the ILAE classification?

<p>They involve substantial neurodevelopmental impact and can include epilepsy. (B)</p> Signup and view all the answers

Which of the following statements about the ILAE classification of epilepsies is true?

<p>It introduces a unified framework addressing all possible etiologies at each diagnostic stage. (D)</p> Signup and view all the answers

Which condition is classified under the Genetic Generalized Epilepsies according to ILAE?

<p>Idiopathic Generalized Epilepsies (C)</p> Signup and view all the answers

What is the primary impact of the new ILAE classification framework on clinical care?

<p>It changes the diagnostic approach and guides patient management effectively. (C)</p> Signup and view all the answers

How does the new ILAE classification reflect current scientific advances?

<p>By updating terminology to align with contemporary research findings. (D)</p> Signup and view all the answers

What is the primary distinction between genetic and idiopathic epilepsies?

<p>Genetic implies a hereditary predisposition while idiopathic relates to unknown origins. (C)</p> Signup and view all the answers

Which type of seizure is characterized by focal onset?

<p>Focal seizure. (B)</p> Signup and view all the answers

Which of the following syndromes does NOT fit the definition of idiopathic generalized epilepsies?

<p>Focal epilepsy. (A)</p> Signup and view all the answers

What does the term 'de novo mutations' imply in the context of genetic epilepsies?

<p>New mutations that occur for the first time in individuals. (C)</p> Signup and view all the answers

Which of the following is NOT a type of epilepsy mentioned?

<p>Structural epilepsy. (D)</p> Signup and view all the answers

What is the current stance on the use of the term 'malignant' in epilepsy classifications?

<p>It is no longer used in classification. (C)</p> Signup and view all the answers

Which of the following statements best describes developmental and/or epileptic encephalopathies?

<p>Seizures may worsen cognitive and behavioral impairments. (B)</p> Signup and view all the answers

What type of epilepsy is characterized by generalized onset?

<p>Juvenile myoclonic epilepsy. (D)</p> Signup and view all the answers

What was the finding regarding the onset of developmental issues in relation to seizure activity?

<p>Developmental delay can precede seizure onset. (C)</p> Signup and view all the answers

Which of the following statements best describes the critical problem of stigma regarding epilepsy?

<p>Stigma mostly arises from a lack of understanding and awareness. (B)</p> Signup and view all the answers

Which structural etiology is listed as a cause for seizure onset types?

<p>Infectious causes. (C)</p> Signup and view all the answers

What does 'CAE' in epilepsy refer to concerning psychosocial impacts?

<p>Childhood Absence Epilepsy. (D)</p> Signup and view all the answers

In the classification of epilepsy syndromes, which term is currently favored over 'malignant'?

<p>Self-limited. (B)</p> Signup and view all the answers

What is a common misconception regarding genetic testing for epilepsy?

<p>Diagnosis relies on clinical evidence rather than solely genetic information. (B)</p> Signup and view all the answers

Which of the following disorders can be a co-morbidity in developmental and/or epileptic encephalopathies?

<p>Cerebral palsy. (D)</p> Signup and view all the answers

What is a significant change in classification regarding benign epilepsies?

<p>They have been renamed to reflect their nature. (B)</p> Signup and view all the answers

Which of the following best describes the timeline of when epileptic encephalopathies can occur?

<p>At any age, including at birth. (D)</p> Signup and view all the answers

What is indicated by the term 'GENE encephalopathy'?

<p>It refers to a genetic component of encephalopathies. (D)</p> Signup and view all the answers

How has the classification of focal and generalized seizures evolved?

<p>There are distinct categories for complex and simple forms. (B)</p> Signup and view all the answers

What characterizes generalized seizures?

<p>They engage bilateral networks rapidly. (D)</p> Signup and view all the answers

What is a defining feature of focal seizures?

<p>They originate within networks limited to one hemisphere. (C)</p> Signup and view all the answers

Which seizure type is not defined with unique characteristics?

<p>Complex partial seizures (A)</p> Signup and view all the answers

Which of the following is an example of a combined epilepsy type?

<p>Dravet syndrome (D)</p> Signup and view all the answers

What describes cognitive seizures?

<p>They include impaired language and positive features like déjà vu. (A)</p> Signup and view all the answers

Which of the following is not considered a structural etiology for seizures?

<p>Cognitive impairments (C)</p> Signup and view all the answers

Which of these seizure types would not specify a level of awareness?

<p>Atonic seizures (B)</p> Signup and view all the answers

What term can be presumed when a seizure type begins with 'focal,' 'generalized,' or 'absence'?

<p>Onset (A)</p> Signup and view all the answers

What type of seizures encompasses both focal impaired awareness seizures and absence seizures?

<p>Combined epilepsies (A)</p> Signup and view all the answers

Which of the following seizure types could lead to feelings of anxiety or joy?

<p>Emotional seizures (B)</p> Signup and view all the answers

Flashcards

Focal Seizures

Seizures originating within one brain hemisphere; can be localized or broadly distributed.

Generalized Seizures

Seizures engaging bilaterally distributed brain networks, affecting cortical and subcortical structures on both sides.

Unknown Onset Seizures

Seizures whose onset type cannot be definitively categorized due to incomplete information.

Seizure Classification Importance

Categorization of seizures to aid the clinical diagnosis of epilepsy.

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Generalized Seizures impact

These involve both brain hemispheres, potentially affecting the entire cortex.

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Genetic Epilepsy

Epilepsy resulting from inherited or new (de novo) genetic mutations.

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Epileptic Encephalopathy

Epileptic activity that worsens cognitive and behavioral impairments.

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ILAE Classification Impact

Simplifies diagnosis and improves understanding; terminology reflects advances.

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Patient Management Focus

Focuses on tailoring care based on the specific epilepsy type and its underlying cause.

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Absence Seizure

A type of seizure that involves a brief loss of awareness, often without noticeable physical symptoms.

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Tonic-Clonic Seizure

A seizure that involves stiffening of the muscles (tonic phase) followed by jerking movements (clonic phase).

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Etiology

The underlying cause or origin of a disease or condition (e.g., structural, genetic, infectious).

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Seizure Etiologies

Underlying causes can be structural, genetic, infectious, metabolic, immune, or unknown.

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Idiopathic Epilepsy

A term for epilepsy where the underlying cause is presumed to be hereditary but not clearly defined.

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Developmental Impact

When epileptic activity can worsen cognitive and behavioral impairments.

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Study Notes

Seizure Classification

  • Classification assists in clinical diagnosis of epilepsy.
  • Seizure types categorized into focal, generalized, and unknown onset.
  • Etiologies include structural, genetic, infectious, metabolic, immune, and unknown origins.

Seizure Types

  • Focal seizures originate within one hemisphere and can be localized or broadly distributed.
  • Generalized seizures engage bilaterally distributed brain networks, affecting cortical and subcortical structures.
  • Unknown onset seizures cannot be categorized definitively.

Generalized and Focal Seizures

  • Generalized seizures involve both hemispheres, potentially engaging parts of the entire cortex.
  • Common examples include absence and tonic-clonic seizures.
  • Focal and generalized seizures can be combined in cases like Dravet syndrome.

Terminology Changes

  • Terms like complex partial, simple partial, and secondarily generalized tonic-clonic are no longer used.
  • Emphasis on using descriptive language rather than strict labels to characterize seizure features.

Epilepsy Types

  • Epilepsy is categorized as focal, generalized, or unknown.
  • Combined epilepsy types exist when definitive syndromal or etiologic diagnosis is not possible.
  • Many patients exhibit both focal impaired awareness and absences.

Genetic and Idiopathic Epilepsies

  • Genetic epilepsy includes inherited and de novo mutations, irrespective of family history.
  • Distinguisher between idiopathic (presumed hereditary) versus clearly defined genetic origins of epilepsy.
  • Stigma associated with epilepsy varies by region and is impacted by genetic understanding.

Developmental and Epileptic Encephalopathies

  • Epileptic activity can exacerbate cognitive and behavioral impairment.
  • Co-morbidities may include developmental delays and disorders like cerebral palsy.
  • Epileptic encephalopathy can arise at any age with potential for mitigative treatments.

Impact of New Classification Framework

  • The ILAE classification simplifies diagnosis and enhances clinical understanding.
  • Updated terminology reflects scientific advancements in the epilepsy field.
  • Emphasizes the importance of etiology and developmental considerations in clinical care.

Key Historical Notes

  • Previously termed symptomatic generalized epilepsies now categorized under developmental and/or epileptic encephalopathies.
  • Historically significant names include childhood absence epilepsy and juvenile myoclonic epilepsy, which are now part of broader classifications.

Clinical and Management Implications

  • Classification changes guide patient management and treatment approaches in epilepsy care.
  • Focus on individualized care based on epilepsy type and etiology improves patient outcomes.

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