Second-Line Pharmacotherapy Options in Reproductive-Aged Women

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Questions and Answers

What is the ovulation rate of gonadotropins in reproductive-aged women?

  • 30%
  • 70% (correct)
  • 40%
  • 80%

Which type of FSH is initially considered for gonadotropin therapy?

  • Recombinant FSH (correct)
  • Luteinizing hormone
  • FSH combined with HCG
  • Urinary FSH

What treatment option is described as less complex with a lower ovulation rate but higher pregnancy rate compared to FSH alone?

  • HCG alone
  • Low dose step-up urinary FSH
  • Gonadotropins
  • HCG combined with FSH (correct)

In patients with PCOS, what has been used to induce ovulation in addition to FSH?

<p>Clomiphene (B)</p> Signup and view all the answers

What is the focus of treatment for PCOS patients?

<p>On presenting symptoms, appearance, reproductive concerns, and long-term health risks (D)</p> Signup and view all the answers

Why is treatment aimed solely at the singular symptom or presentation without considering underlying factors deemed ineffective?

<p>It may not address the root cause (C)</p> Signup and view all the answers

What is a potential disadvantage of using gonadotropins for ovulation induction in PCOS patients?

<p>Increased risk of multiple pregnancy (A)</p> Signup and view all the answers

Which therapy is most likely to be recommended for women with PCOS experiencing oligomenorrhoea and severe hirsutism?

<p>Metformin (A)</p> Signup and view all the answers

What is the primary effect of metformin in PCOS according to the text?

<p>Improving insulin resistance (D)</p> Signup and view all the answers

Why are glucocorticoids considered for treating PCOS according to the text?

<p>To inhibit androgen biosynthesis (D)</p> Signup and view all the answers

Which hormone's production is reduced by glucocorticoids in PCOS patients?

<p>Androgens (D)</p> Signup and view all the answers

What is the potential risk of using high doses of gonadotropins in PCOS patients?

<p>Sudden increase in estradiol (D)</p> Signup and view all the answers

What is a potential effect of metformin on testosterone levels in patients with PCOS?

<p>Reduce testosterone levels (C)</p> Signup and view all the answers

What is the rationale behind using metformin in PCOS therapy according to the text?

<p>To improve hyperinsulinaemia (A)</p> Signup and view all the answers

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