14 Questions
What is the ovulation rate of gonadotropins in reproductive-aged women?
70%
Which type of FSH is initially considered for gonadotropin therapy?
Recombinant FSH
What treatment option is described as less complex with a lower ovulation rate but higher pregnancy rate compared to FSH alone?
HCG combined with FSH
In patients with PCOS, what has been used to induce ovulation in addition to FSH?
Clomiphene
What is the focus of treatment for PCOS patients?
On presenting symptoms, appearance, reproductive concerns, and long-term health risks
Why is treatment aimed solely at the singular symptom or presentation without considering underlying factors deemed ineffective?
It may not address the root cause
What is a potential disadvantage of using gonadotropins for ovulation induction in PCOS patients?
Increased risk of multiple pregnancy
Which therapy is most likely to be recommended for women with PCOS experiencing oligomenorrhoea and severe hirsutism?
Metformin
What is the primary effect of metformin in PCOS according to the text?
Improving insulin resistance
Why are glucocorticoids considered for treating PCOS according to the text?
To inhibit androgen biosynthesis
Which hormone's production is reduced by glucocorticoids in PCOS patients?
Androgens
What is the potential risk of using high doses of gonadotropins in PCOS patients?
Sudden increase in estradiol
What is a potential effect of metformin on testosterone levels in patients with PCOS?
Reduce testosterone levels
What is the rationale behind using metformin in PCOS therapy according to the text?
To improve hyperinsulinaemia
Explore the pharmacotherapeutic options for inducing ovulation in reproductive-aged women beyond initial gonadotropin therapy. Learn about the effectiveness and cost considerations associated with second-line treatments like low dose step-up regimens. Test your knowledge on these advanced treatment modalities.
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