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Second-Line Pharmacotherapy Options in Reproductive-Aged Women

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Second-Line Pharmacotherapy Options in Reproductive-Aged Women

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Questions and Answers

What is the ovulation rate of gonadotropins in reproductive-aged women?

30%

70% (correct)

40%

80%

Which type of FSH is initially considered for gonadotropin therapy?

Recombinant FSH (correct)

Luteinizing hormone

FSH combined with HCG

Urinary FSH

What treatment option is described as less complex with a lower ovulation rate but higher pregnancy rate compared to FSH alone?

HCG alone

Low dose step-up urinary FSH

Gonadotropins

HCG combined with FSH (correct)

In patients with PCOS, what has been used to induce ovulation in addition to FSH?

Clomiphene Signup and view all the answers

What is the focus of treatment for PCOS patients?

On presenting symptoms, appearance, reproductive concerns, and long-term health risks Signup and view all the answers

Why is treatment aimed solely at the singular symptom or presentation without considering underlying factors deemed ineffective?

It may not address the root cause Signup and view all the answers

What is a potential disadvantage of using gonadotropins for ovulation induction in PCOS patients?

Increased risk of multiple pregnancy Signup and view all the answers

Which therapy is most likely to be recommended for women with PCOS experiencing oligomenorrhoea and severe hirsutism?

Metformin Signup and view all the answers

What is the primary effect of metformin in PCOS according to the text?

Improving insulin resistance Signup and view all the answers

Why are glucocorticoids considered for treating PCOS according to the text?

To inhibit androgen biosynthesis Signup and view all the answers

Which hormone's production is reduced by glucocorticoids in PCOS patients?

Androgens Signup and view all the answers

What is the potential risk of using high doses of gonadotropins in PCOS patients?

Sudden increase in estradiol Signup and view all the answers

What is a potential effect of metformin on testosterone levels in patients with PCOS?

Reduce testosterone levels Signup and view all the answers

What is the rationale behind using metformin in PCOS therapy according to the text?

To improve hyperinsulinaemia Signup and view all the answers