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Questions and Answers

What is the goal of schizophrenia treatment?

  • Suppression of acute episodes
  • Prevention of acute exacerbations
  • Maintenance of functioning
  • All of the above (correct)

    • First-generation antipsychotics can cause irreversible tardive dyskinesia.

    True

    What type of antipsychotics is known for a lower risk of EPS?

    Second-generation antipsychotics

    Chlorpromazine, haloperidol, thioridazine, and pimozide can cause fatal ______.

    <p>dysrhythmias</p> Signup and view all the answers

    Which antipsychotic is known to improve positive, negative, and cognitive symptoms?

    <p>Clozapine</p> Signup and view all the answers

    Depot antipsychotics are used for long-term therapy.

    <p>True</p> Signup and view all the answers

    Patients must enroll in the REMS program prior to receiving ______.

    <p>Clozapine</p> Signup and view all the answers

    What are the common adverse effects of Clozapine?

    <p>All of the above</p> Signup and view all the answers

    What should be done if a patient's white blood cell count falls below normal while on Clozapine?

    <p>The drug must be stopped and blood count monitored for 4 weeks.</p> Signup and view all the answers

    What are the 5 major classes of antidepressants?

    <p>Selective Serotonin Reuptake Inhibitors (SSRIs)</p> Signup and view all the answers

    SSRIs can cause hypotension and sedation.

    <p>False</p> Signup and view all the answers

    What is a common adverse effect of SSRIs?

    <p>Sexual Dysfunction</p> Signup and view all the answers

    Which medications may be added to SSRIs to manage sexual dysfunction?

    <p>Bupropion, Nefazodone, and Mirtazapine</p> Signup and view all the answers

    Fluoxetine can elevate plasma levels of _____ and _____ due to high protein binding.

    <p>TCAs, Lithium</p> Signup and view all the answers

    MAOIs should be stopped two weeks prior to starting SSRIs.

    <p>True</p> Signup and view all the answers

    What is a potential side effect of the antidepressant Bupropion?

    <p>Seizures</p> Signup and view all the answers

    What is Sertraline known for in relation to breastfeeding?

    <p>It is the safest option for breastfeeding.</p> Signup and view all the answers

    Brexanolone is the first FDA approved option for _____, infused over 60 hours in a hospital.

    <p>Postpartum Depression</p> Signup and view all the answers

    What drug class does Venlafaxine belong to?

    <p>Serotonin-Norepinephrine Reuptake Inhibitors</p> Signup and view all the answers

    What are the preferred mood stabilizers for bipolar disorder?

    <p>Lithium</p> Signup and view all the answers

    What is the plasma level range for lithium?

    <p>0.8-1.4</p> Signup and view all the answers

    The drug that is the drug of choice for bipolar disorder is _____.

    <p>lithium</p> Signup and view all the answers

    Clozapine is safe for long-term use without any monitoring.

    <p>False</p> Signup and view all the answers

    Which of the following medications can cause respiratory depression when combined with other CNS depressants?

    <p>All of the above</p> Signup and view all the answers

    Which sedative is known for not having limitations on how long to use?

    <p>eszopiclone</p> Signup and view all the answers

    Ramelteon has no effect on prolactin or testosterone levels.

    <p>False</p> Signup and view all the answers

    What is the main side effect to watch for with alprazolam?

    <p>Dependence</p> Signup and view all the answers

    Long-term maintenance for mood stabilization can be achieved with ______.

    <p>lamotrigine</p> Signup and view all the answers

    Which of the following SSRIs are approved for the treatment of generalized anxiety disorder?

    <p>Escitalopram</p> Signup and view all the answers

    What are the first-choice medications for acute anxiety?

    <p>Benzodiazepines</p> Signup and view all the answers

    Buspirone can intensify the effects of other CNS depressants.

    <p>False</p> Signup and view all the answers

    List two SSRIs used for panic disorder.

    <p>Fluoxetine, Paroxetine, Sertraline</p> Signup and view all the answers

    Which of the following is an SNRI approved for PTSD?

    <p>Venlafaxine</p> Signup and view all the answers

    The primary treatment for ADHD is __________.

    <p>stimulants</p> Signup and view all the answers

    Name one non-stimulant medication used to treat ADHD.

    <p>Atomoxetine</p> Signup and view all the answers

    Methylphenidate has a potential for abuse and is classified as a Schedule II drug.

    <p>True</p> Signup and view all the answers

    Which of the following can increase the levels of Atomoxetine?

    <p>CYP inhibitors</p> Signup and view all the answers

    Which compound is primarily part of CNS stimulants for ADHD?

    <p>Dextroamphetamine</p> Signup and view all the answers

    Which of the following medications is used to decrease craving for alcohol?

    <p>Naltrexone</p> Signup and view all the answers

    Disulfiram causes unpleasant effects if alcohol is ingested.

    <p>True</p> Signup and view all the answers

    What is the treatment of choice for opioid overdose?

    <p>Naloxone</p> Signup and view all the answers

    Which medication should not be used by truck/bus drivers, pilots, or air traffic controllers?

    <p>Varenicline</p> Signup and view all the answers

    The syndrome caused by disulfiram when alcohol is ingested is called __________.

    <p>acetaldehyde syndrome</p> Signup and view all the answers

    What is the low potential abuse medication safer than methadone?

    <p>Buprenorphine</p> Signup and view all the answers

    What are the adverse effects associated with nicotine gum?

    <p>Mouth and throat soreness</p> Signup and view all the answers

    Study Notes

    Schizophrenia Treatment Goals

    • Suppress acute episodes
    • Prevent acute exacerbations
    • Maintain functioning

    First-Generation Antipsychotics

    • Block dopamine receptors, causing extrapyramidal symptoms (EPS)
    • Examples: chlorpromazine, haloperidol, thioridazine, pimozide
    • Adverse Effects (AE):
      • Overdose: hypotension, CNS depression, EPS
      • Tardive dyskinesia (can be irreversible)
      • Dystonia: spasm of tongue, face, neck, or back, oculogyric crisis, opisthotonos
      • Joint dislocation
      • Antipsychotic parkinsonism
      • Akathisia
      • Neuroleptic malignant syndrome (treat with dantrolene and bromocriptine)
    • Initial treatment: anticholinergics (benztopine, diphenhydramine)

    Haloperidol

    • Can be used in children
    • AE: galactorrhea, gynecomastia, menstrual irregularities, prolong QT

    Second-Generation Antipsychotics

    • Block dopamine and serotonin receptors, reducing EPS risk
    • AE:
      • Weight gain
      • Diabetes mellitus (DM)
      • Dyslipidemia

    Clozapine

    • Most effective, improves positive, negative, and cognitive symptoms
    • AE:
      • Agranulocytosis (enroll in REMS program, monitor WBC and neutrophil count)
      • Myocarditis (black box warning)
      • Interactions: cancer drugs, phenytoin, ketoconazole

    Depot Antipsychotics

    • Injectable formulation for long-term therapy
    • Lower rate of relapse
    • Better for patients with adherence difficulty
    • Slow, steady absorption, constant plasma levels between doses
    • Dosing: every 2-4 weeks
    • Examples: asenapine (SGA, available in sublingual), loxapine (available in 10mg inhaled powder, 1 inhalation/24 hrs)

    Treatment Duration

    • Continue therapy for at least 12 months after control of an acute episode

    Antidepressants

    • Depression is caused by the functional insufficiency of monoamine neurotransmitters norepinephrine, serotonin, or both, according to the monoamine deficiency hypothesis.

    Classes of Antidepressants

    • 5 major classes of antidepressants:
      • Selective serotonin reuptake inhibitors (SSRIs)
      • Serotonin-norepinephrine reuptake inhibitors (SNRIs)
      • Tricyclic antidepressants (TCAs)
      • Monoamine oxidase inhibitors (MAOIs)
      • Atypical antidepressants

    Selective Serotonin Reuptake Inhibitors (SSRIs)

    • Examples: citalopram, escitalopram, fluvoxamine, paroxetine, and sertraline
    • Do not cause hypotension, sedation, or anticholinergic effects
    • Fluoxetine causes CNS excitation rather than sedation
    • Adverse effects (AE):
      • Sexual dysfunction (can lower dose or take holidays or add a medication)
      • Weight gain
      • Bruxism, vivid dreams, bleeding disorders, and increased perspiration
      • Birth defects are low
    • Serotonin syndrome is possible AE 2-72 hours after treatment, symptoms resolve once the drug is stopped
    • Risk of serotonin syndrome if given with MAOIs

    Monoamine Oxidase Inhibitors (MAOIs)

    • Increases 5-HT availability
    • Reserved for patients who have not responded to other medications due to hazards
    • Administered orally
    • Examples: isocarboxazid, phenelzine, and tranylcypromine
    • Can cause hypertensive crisis triggered by foods rich in tyramine
    • Do not dispense to those who cannot follow dietary restrictions
    • Treatment for hypertensive crisis: vasodilators (nitro, phentolamine, and labetalol)

    Selegilin (Transdermal MAOI)

    • Bypasses first-pass effect, preserving MAO-A in the intestines, with a low risk with tyramine-rich foods
    • Adverse effect: rash
    • Contraindications: carbamazepine and oxcarbazepine raise levels of selegilin

    Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)

    • Examples: venlafaxine, desvenlafaxine, duloxetine, levomilnacipran, and milnacipran
    • Milnacipran: treats fibromyalgia and sleep
    • Duloxetine: off-label for chemo-induced neuropathy and stress urinary incontinence
    • Desvenlafaxine: approved for adults, off-label for hot flashes in menopause, and causes weight gain
    • Venlafaxine: blocks NE and 5-HT, fetal withdrawal in late pregnancy, and suicide in young

    Tricyclic Antidepressants (TCAs)

    • Block reuptake of two monoamine transmitters, NE, and serotonin
    • Adverse effects:
      • Sedation
      • Orthostatic hypotension
      • Anticholinergic effect
      • Cardiac toxicity
    • Lethal if overdose, bicarbonate for dysrhythmias
    • Long half-lives, single daily dose
    • TCA with MAOI: severe hypertension
    • If sedation is warranted: doxepin
    • If it's not: desipramine
    • Elderly sensitive to anticholinergic effects: nortriptyline

    Atypical Antidepressants

    • Bupropion:
      • Weight loss
      • Increases sexual desire
      • Can be used with SSRIs
      • Uses: major depressive disorder, prevention of seasonal affective disorder, and stop smoking
      • Adverse effects:
        • Seizures
        • Avoid doses above 450mg/day
        • Rapid dosage titration
        • Patients with seizure risk factors
        • Anorexia and drugs that inhibit CYP (increases bupropion levels)
      • Interactions: sertraline, fluoxetine, paroxentine, and MAOIs
    • Mirtazapine:
      • Blocks histamine receptors, promotes sedation and weight gain
      • Adverse effect: somnolence

    Postpartum Depression

    • Fluoxetine, sertraline, and venlafaxine
    • SSRIs are the first choice: tolerated and low risk for toxicity with overdose
    • Prevent relapse: treatment should continue at least 6 months
    • Sertraline is the safest for breastfeeding
    • Brexanolone: first FDA-approved option for PPD, infused over 60 hours in the hospital

    Bipolar Disorder Treatment

    • Mood stabilizers, antipsychotics, and antidepressants are used to treat bipolar disorder, including bupropion, venlafaxine, and SSRIs (fluoxetine and sertraline).
    • Lithium and valproate are preferred, often combined with a 2nd generation (atypical) antipsychotic.

    Lithium

    • Lithium is the drug of choice for bipolar disorder treatment.
    • Monitor blood levels regularly, as it has a short half-life and is excreted daily, requiring divided doses.
    • Kidneys excrete lithium, and low sodium levels can cause kidney retention, leading to toxicity.
    • Normal sodium intake is essential, and diuretics should be used with caution.
    • Plasma levels should be kept between 0.8-1.4 and monitored every 2-3 days initially, then every 3-6 months.
    • Levels above 1.5 can cause GI symptoms, hand tremors, confusion, and muscle hyperirritability.
    • Levels above 2 can cause seizures, hypotension, coma, and death.
    • Lithium can also cause goiter and hypothyroidism.
    • Interactions with diuretics, NSAIDs, and anticholinergic drugs can occur due to urinary hesitancy.

    Antiepileptic Drugs

    • Divalproex, carbamazepine, and lamotrigine are used to treat bipolar disorder.
    • Carbamazepine has a trough level of 4-12.
    • Lamotrigine is used for long-term maintenance.

    Antipsychotics

    • Olanzapine, quetiapine, risperidone, aripiprazole, lurasidone, cariprazine, asenapine, and ziprasidone are used to treat bipolar disorder.
    • Clozapine can cause agranulocytosis.
    • Only aripiprazole, olanzapine, and ziprasidone are approved for long-term use to prevent mood episode recurrence.

    Sedatives/Hypnotics

    • Barbiturates are schedule III drugs that can cause tolerance and dependence, and are more powerful respiratory depressants that can be fatal in overdose.
    • Barbiturates have important applications in seizure and anesthesia, and should be withdrawn slowly.
    • Benzodiazepines are the first choice for treating insomnia and anxiety, but can cause confusion and anterograde amnesia.
    • Benzodiazepines are weak respiratory depressants, but caution is needed with COPD.
    • Alprazolam has a high risk of dependence.

    Benzo-like Drugs

    • Zolpidem, zaleplon, and eszopiclone are used to treat insomnia.
    • Eszopiclone has no limitation on duration of use and can help with sleep maintenance, but has a bitter aftertaste.
    • Zaleplon is used for short-term insomnia and helps with falling asleep.
    • Zolpidem is used for short-term insomnia and helps with falling asleep and staying asleep.

    Ramelteon

    • Ramelteon is a new hypnotic that can increase prolactin levels and reduce testosterone levels, leading to amenorrhea, galactorrhea, reduced libido, and fertility problems.
    • Fluvoxamine can increase ramelteon levels, and caution is needed with hepatic impairment.

    Suvorexant and Lemborexant

    • Suvorexant and lemborexant are used to treat chronic insomnia.
    • They should not be used with CYP inhibitors (ketoconazole, clarithromycin) or in patients with COPD, OSA, or narcolepsy.
    • They can increase digoxin levels.

    Trazadone

    • Trazadone is an atypical antidepressant with no tolerance.
    • Adverse effects include daytime grogginess and postural hypotension.

    Anxiety Disorders

    • SSRIs and SNRIs are the first-line treatment for generalized anxiety disorder, with only four antidepressants approved: venlafaxine and duloxetine (SNRIs), and paroxetine and escitalopram (SSRIs).
    • Benzodiazepines are the first choice for acute anxiety, with examples including alprazolam, lorazepam, chlordiazepoxide, clorazepate, diazepam, and oxazepam.
    • Sedation and psychomotor slowing caused by benzodiazepines will subside in 7-10 days.
    • Buspirone is an anxiolytic that is not a CNS depressant, has no abuse potential, and does not intensify the effects of other CNS depressants, but its anxiolytic effects are delayed.

    Panic Disorder

    • SSRIs are the first-line drugs for panic disorder, with examples including fluoxetine, paroxetine, and sertraline.

    Obsessive-Compulsive Disorder (OCD)

    • SSRIs are the first-line drugs for OCD, with examples including fluoxetine, fluvoxamine, paroxetine, and sertraline.
    • TCAs are the second-line treatment, with clomipramine being an example.

    Social Anxiety Disorder

    • SSRIs are the first-line drugs, with examples including paroxetine and sertraline.
    • Benzodiazepines or beta-blockers can also be used for performance anxiety.

    Post-Traumatic Stress Disorder (PTSD)

    • SSRIs are the first-line drugs, with examples including fluoxetine, paroxetine, and sertraline.
    • SNRIs, such as venlafaxine, can also be used.

    CNS Stimulants

    • Amphetamines are CNS stimulants used to treat ADHD and narcolepsy, and have a 50:50 compound of dextro and levo.
    • They release NE and dopamine, and inhibit reuptake, causing peripheral actions of cardiac stimulation and vasoconstriction.
    • They have a potential for abuse and side effects including CNS stimulation, weight loss, CV effects, and psychosis.
    • Methylphenidate is a CNS stimulant with side effects including insomnia, reduced appetite, emotional lability, and abuse (Schedule II).
    • Modafinil is a non-amphetamine stimulant that is absorbed in the GI, and has less abuse potential (Schedule IV).
    • Modafinil decreases the effects of birth control and cyclosporine.

    Attention Deficit Hyperactivity Disorder (ADHD)

    • Stimulants are the first-line treatment, with examples including methylphenidate, dexmethylphenidate, dextroamphetamine, and lisdexamfetamine.
    • Side effects of stimulants include insomnia and growth suppression, which can be reduced by taking smaller doses in the afternoon and administering during or after meals.
    • Non-stimulant treatments for ADHD include atomoxetine, which is an inhibitor of NE, and guanfacine and clonidine, which are not controlled substances and do not cause anorexia or insomnia.

    Drugs with Abuse Potential

    Alcohol

    • Naltrexone decreases craving for alcohol
    • Acamprosate reduces unpleasant feelings brought on by abstinence
    • Disulfiram helps to avoid drinking by causing unpleasant effects (acetaldehyde syndrome) if alcohol is ingested, and patients must avoid all forms of alcohol

    Smoking

    • Medications to help quit:
      • Lozenges
      • Nicoderm and nicotrol patches
      • Nicotine inhaler (not for patients with asthma)
      • Nicotine nasal spray
      • Nicotine gum (AE: mouth and throat soreness)
    • Nicotine gum: after 3 months without nicotine, patients should discontinue by tapering
    • Other medications:
      • Bupropion
      • Varenicline (AE: CV events; cannot use if truck/bus driver, pilot, or air traffic controllers)

    Opioids

    • Examples: heroin, oxycodone
    • Naloxone is the treatment of choice (autoinjector and nasal spray)
    • Medications for maintenance:
      • Opioid agonist (methadone) substituted for those not ready for detox
      • Opioid agonist-antagonist (buprenorphine) substituted for those not ready for detox
    • Naltrexone is used for discouragement after detox
    • Buprenorphine:
      • Can be prescribed in primary care offices with 8 hours of training and registration with SAMHSA
      • Low potential for abuse, safer than methadone
    • Methadone:
      • Suppressive therapy: giving addicts progressively larger doses until 120mg/day
      • AE: prolongs QT and respiratory depression
      • Prescribed in programs

    Barbiturates

    • Cross-dependency exists between barbiturates and other CNS depressants, but not with opioids
    • Phenobarbital can help with withdrawal

    Benzodiazepines

    • Flumazenil is used for overdose

    Methamphetamine

    • Treatment: bupropion and modafinil

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    Description

    This quiz covers the goals and treatment of schizophrenia, including the use of conventional antipsychotics, their potency, and potential side effects such as movement disorders and overdose symptoms.

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