SAA, Familial Mediterranean Fever, and Amyloidosis Quiz
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Questions and Answers

What is the role of serum amyloid A (SAA) in Familial Mediterranean Fever (FMF)?

  • It is an acute phase reactant increased in FMF (correct)
  • It leads to localized amyloidosis in FMF patients
  • It is decreased in FMF
  • It causes dysfunction of neutrophils
  • Which clinical finding is NOT a classic presentation of systemic amyloidosis?

  • Nephrotic syndrome
  • Tongue enlargement
  • Joint pain (correct)
  • Restrictive cardiomyopathy
  • What is required for the diagnosis of amyloidosis?

  • Tissue biopsy (correct)
  • MRI scan
  • Urinalysis
  • Blood test
  • In which condition does senile cardiac amyloidosis typically occur?

    <p>Individuals over 80 years old</p> Signup and view all the answers

    What is the main organ involved in nephrotic syndrome associated with amyloidosis?

    <p>Kidney</p> Signup and view all the answers

    What is the relationship between the stress placed on an organ and growth adaptations?

    <p>An increase, decrease, or change in stress can result in growth adaptations.</p> Signup and view all the answers

    What is the major cause of localized cardiac amyloidosis?

    <p>Mutated serum transthyretin deposition</p> Signup and view all the answers

    Which process involves an increase in organ size through the number of cells?

    <p>Hyperplasia</p> Signup and view all the answers

    What contributes to hyperplasia but not hypertrophy?

    <p>Increase in cell number</p> Signup and view all the answers

    Which type of necrosis is characterized by necrotic damage to the blood vessel wall and results in bright pink staining of the wall microscopically?

    <p>Fibrinoid necrosis</p> Signup and view all the answers

    Which process involves the deposition of calcium on dead tissues, as seen in necrotic adipose tissue with a chalky-white appearance?

    <p>Saponification</p> Signup and view all the answers

    Metastatic calcification differs from dystrophic calcification in that it occurs when high serum levels of what lead to calcium deposition in normal tissues?

    <p>Phosphate</p> Signup and view all the answers

    What type of necrosis is characteristic of trauma to fat tissues like the breast and pancreatitis-mediated damage to peripancreatic fat?

    <p>Fat necrosis</p> Signup and view all the answers

    In which condition does saponification occur, leading to the chalky-white appearance of necrotic adipose tissue?

    <p>Pancreatitis</p> Signup and view all the answers

    Which of the following conditions can lead to metastatic calcification where high serum levels cause calcium deposition in normal tissues?

    <p>Hyperparathyroidism</p> Signup and view all the answers

    Which protein is an inactive proinflammatory protein that is activated upon exposure to subendothelial or tissue collagen?

    <p>Hageman factor (Factor XII)</p> Signup and view all the answers

    What causes the redness and warmth associated with inflammation?

    <p>Histamine, prostaglandins, and bradykinin</p> Signup and view all the answers

    What is the function of MAC in the inflammatory response?

    <p>Lyses microbes by creating a hole in the cell membrane</p> Signup and view all the answers

    What sensitizes sensory nerve endings to cause pain during inflammation?

    <p>Prostaglandin E2 (PGE2)</p> Signup and view all the answers

    Which condition is characterized by a lack of thymus, lack of parathyroids, and abnormalities of the heart, great vessels, and face?

    <p>22q11 microdeletion</p> Signup and view all the answers

    Which etiology of Severe Combined Immunodeficiency (SCID) is characterized by the necessity of cytokine signaling for B and T cell proliferation and maturation?

    <p>Cytokine receptor defects</p> Signup and view all the answers

    Which immunodeficiency condition is caused by a mutation in Bruton tyrosine kinase?

    <p>X-linked Agammaglobulinemia</p> Signup and view all the answers

    A condition characterized by susceptibility to fungal, viral, bacterial, and protozoal infections, including opportunistic infections and live vaccines, is most likely:

    <p>Severe Combined Immunodeficiency (SCID)</p> Signup and view all the answers

    Which condition is characterized by a complete lack of immunoglobulin due to disordered B-cell maturation?

    <p>X-linked Agammaglobulinemia</p> Signup and view all the answers

    What is the characteristic feature of Common Variable Immunodeficiency (CVID) related to immunoglobulin?

    <p>Low immunoglobulin due to B-cell or helper T-cell defects</p> Signup and view all the answers

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