Lecture 22 – Protein in action: Myoglobin and hemoglobin

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Questions and Answers

What is the primary function of hemoglobin in the blood?

  • To transport carbon dioxide
  • To carry oxygen (correct)
  • To facilitate glucose metabolism
  • To regulate blood pH

How much oxygen is typically carried in solution in blood?

  • 1%
  • 5% (correct)
  • 20%
  • 50%

At what partial pressure of oxygen (torr) does hemoglobin release oxygen most effectively?

  • 10 torr
  • 20 torr (correct)
  • 100 torr
  • 60 torr

What is the saturation of myoglobin in metabolizing tissue at 20 torr?

<p>91% (B)</p> Signup and view all the answers

What type of binding does hemoglobin exhibit?

<p>Cooperative binding (B)</p> Signup and view all the answers

What is the structure of myoglobin?

<p>Monomer (B)</p> Signup and view all the answers

How many α-helices are present in the structure of myoglobin?

<p>8 (C)</p> Signup and view all the answers

What is the role of heme in myoglobin and hemoglobin?

<p>It binds oxygen. (B)</p> Signup and view all the answers

What is the difference between the tetrameric structure of hemoglobin and myoglobin?

<p>Hemoglobin has four binding sites; myoglobin has one. (B)</p> Signup and view all the answers

What are the two conformational states of hemoglobin?

<p>T and R (B)</p> Signup and view all the answers

What effect does 2,3-bisphosphoglycerate (BPG) have on hemoglobin?

<p>It decreases the affinity for oxygen. (B)</p> Signup and view all the answers

What does the term "sigmoidal binding curve" indicate?

<p>Cooperative binding (B)</p> Signup and view all the answers

What is the primary sequence similarity between hemoglobin and myoglobin?

<p>17% identical residues (B)</p> Signup and view all the answers

What is the Bohr effect?

<p>Decreased oxygen affinity at lower pH (A)</p> Signup and view all the answers

What happens to the iron atom in heme when oxygen binds?

<p>It is pulled into the plane of the heme. (C)</p> Signup and view all the answers

What type of protein is myoglobin classified as?

<p>Transport protein (C)</p> Signup and view all the answers

What is the quaternary structure of hemoglobin described as?

<p>Tetrameric (C)</p> Signup and view all the answers

How does the T state of hemoglobin differ from the R state?

<p>T state has low affinity for oxygen; R state has high affinity. (B)</p> Signup and view all the answers

Which of the following stabilizes the T state of hemoglobin?

<p>Low pH and CO2 binding (B)</p> Signup and view all the answers

What structural feature allows myoglobin to effectively bind oxygen?

<p>The heme group (C)</p> Signup and view all the answers

What happens to hemoglobin's affinity for oxygen at high altitudes?

<p>It increases due to lower oxygen levels. (A)</p> Signup and view all the answers

What is the significance of the proximal histidine in hemoglobin and myoglobin?

<p>It coordinates the iron in heme. (B)</p> Signup and view all the answers

What is the role of distal histidine in heme?

<p>It stabilizes oxygen binding. (A)</p> Signup and view all the answers

What is the effect of fetal hemoglobin (HbF) compared to adult hemoglobin (HbA)?

<p>HbF has a higher affinity for oxygen. (C)</p> Signup and view all the answers

What is the primary function of myoglobin in muscle tissue?

<p>To store oxygen (B)</p> Signup and view all the answers

What happens to the binding of oxygen to hemoglobin when the first oxygen molecule binds?

<p>The affinity for oxygen in neighboring subunits increases. (C)</p> Signup and view all the answers

How does the presence of CO2 affect hemoglobin's oxygen affinity?

<p>Decreases it (B)</p> Signup and view all the answers

Which model describes the binding of oxygen to hemoglobin as a series of sequential changes in conformation?

<p>Sequential model (B)</p> Signup and view all the answers

What is the primary difference between the T state and R state in terms of oxygen binding?

<p>R state has higher affinity for oxygen. (D)</p> Signup and view all the answers

Why is myoglobin not suitable for oxygen transport?

<p>It binds oxygen too tightly. (C)</p> Signup and view all the answers

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