Podcast
Questions and Answers
Which route of drug administration is suitable for drugs destroyed by gastrointestinal enzymes?
Which route of drug administration is suitable for drugs destroyed by gastrointestinal enzymes?
- Rectal route (correct)
- Gastric gavage
- Intravenous route
- Buccal route
What is the advantage of the buccal route of drug administration?
What is the advantage of the buccal route of drug administration?
- Delayed onset of action
- High bioavailability (correct)
- Disagreement with the body's metabolism
- First-pass metabolism
In which condition is the gastric gavage route commonly used?
In which condition is the gastric gavage route commonly used?
- Coma (correct)
- Vomiting
- Emergency situations
- Convulsions
Which route of drug administration offers 100% bioavailability?
Which route of drug administration offers 100% bioavailability?
What is the disadvantage of the oral route of drug administration?
What is the disadvantage of the oral route of drug administration?
Flashcards
Drug destroyed by GI enzymes?
Drug destroyed by GI enzymes?
Rectal route is best for drugs broken down by stomach/intestine enzymes.
Buccal route advantage?
Buccal route advantage?
High absorption rate into the bloodstream.
Gastric gavage use?
Gastric gavage use?
Used for patients that can't swallow medication (i.e., unconscious patients).
100% bioavailability route?
100% bioavailability route?
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Oral route disadvantage?
Oral route disadvantage?
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Study Notes
Routes of Drug Administration
- Parenteral route is suitable for drugs destroyed by gastrointestinal enzymes, as it bypasses the digestive system.
- The advantage of the buccal route of drug administration is that it allows for rapid absorption of the drug into the bloodstream, while avoiding hepatic first-pass metabolism.
- The gastric gavage route is commonly used in research involving animals, particularly in toxicology studies.
- The intravenous (IV) route offers 100% bioavailability, as the drug is directly injected into the bloodstream.
- The disadvantage of the oral route of drug administration is that it is susceptible to hepatic first-pass metabolism and degradation by gastrointestinal enzymes, which can reduce the bioavailability of the drug.
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