20 Questions
What is a significant influence on the ultimate drug deposition patterns in pulmonary drug administration?
Particle size
What is the average optimal particle size for deep lung drug deposition in pulmonary drug administration?
15μm
Which type of drug administration can result in both local and systemic effects depending on drug deposition?
Pulmonary Drug Administration
How do pulmonary pathological conditions affect drug deposition patterns?
They can affect the deposition patterns
Which factor plays a crucial role in differentiating formulations and devices for pulmonary drug administration?
Physiological factors
What is a key advantage of drugs absorbed from the lungs?
They avoid hepatic first-pass metabolism
Why must formulations intended for parenteral administration be sterile, nonimmunogenic, and pyrogen free?
To prevent infections as they bypass skin defenses
Which factor influences the rate and extent of systemic drug availability following parenteral administration?
Drug physicochemical properties
How do intradermal and subcutaneous injections differ in terms of drug absorption?
Subcutaneous injections can be absorbed by the lymphatic system
Why might some insulin formulations slow the rate of drug release after subcutaneous administration?
To address unpredictable and erratic drug concentrations
What is the optimal average particle size for drug deposition in the deep lung during pulmonary drug administration?
15 μm
Which factor plays a crucial role in determining the differences between formulations and devices used in pulmonary drug administration?
Particle size
How can pulmonary drug administration lead to systemic effects?
Through absorption into the bloodstream
What type of delivery does pulmonary drug administration involve?
Inhaled delivery
How are inhaled drugs typically administered to the respiratory system?
As fine liquid droplets or solid particles
Why is it essential for formulations intended for parenteral administration to be sterile, nonimmunogenic, and pyrogen free?
To avoid immune reactions and infections upon administration
What distinguishes intradermal (ID) injections from subcutaneous (SC) injections in terms of drug administration?
Depth of penetration into the skin layers
Which factor contributes to the unpredictable systemic drug concentrations after subcutaneous (SC) drug administration?
Drainage into the lymphatic system
Why do drugs absorbed from the lungs avoid hepatic first-pass metabolism?
Due to direct entry into the systemic circulation
How does drug absorption after intravenous (IV) administration differ from other routes?
Leads to immediate and direct systemic distribution
This quiz covers the physiological aspects of common routes of drug administration, dosage forms, barriers to systemic drug absorption, and the pros and cons of different routes of drug administration. Topics discussed include pulmonary drug administration and parenteral drug administration.
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