Routes of Drug Administration Part 2: Physiological Considerations

Play an AI-generated podcast conversation about this lesson

What is a significant influence on the ultimate drug deposition patterns in pulmonary drug administration?

Drug concentration

Temperature of the drug

Color of the drug

Particle size (correct)

What is the average optimal particle size for deep lung drug deposition in pulmonary drug administration?

15μm (correct)

5μm

20μm

10μm

Which type of drug administration can result in both local and systemic effects depending on drug deposition?

Pulmonary Drug Administration (correct)

Oral Drug Administration

Nasal Drug Administration

Dermal Drug Administration

How do pulmonary pathological conditions affect drug deposition patterns?

They can affect the deposition patterns Signup and view all the answers

Which factor plays a crucial role in differentiating formulations and devices for pulmonary drug administration?

Physiological factors Signup and view all the answers

What is a key advantage of drugs absorbed from the lungs?

They avoid hepatic first-pass metabolism Signup and view all the answers

Why must formulations intended for parenteral administration be sterile, nonimmunogenic, and pyrogen free?

To prevent infections as they bypass skin defenses Signup and view all the answers

Which factor influences the rate and extent of systemic drug availability following parenteral administration?

Drug physicochemical properties Signup and view all the answers

How do intradermal and subcutaneous injections differ in terms of drug absorption?

Subcutaneous injections can be absorbed by the lymphatic system Signup and view all the answers

Why might some insulin formulations slow the rate of drug release after subcutaneous administration?

To address unpredictable and erratic drug concentrations Signup and view all the answers

What is the optimal average particle size for drug deposition in the deep lung during pulmonary drug administration?

15 μm Signup and view all the answers

Which factor plays a crucial role in determining the differences between formulations and devices used in pulmonary drug administration?

Particle size Signup and view all the answers

How can pulmonary drug administration lead to systemic effects?

Through absorption into the bloodstream Signup and view all the answers

What type of delivery does pulmonary drug administration involve?

Inhaled delivery Signup and view all the answers

How are inhaled drugs typically administered to the respiratory system?

As fine liquid droplets or solid particles Signup and view all the answers

Why is it essential for formulations intended for parenteral administration to be sterile, nonimmunogenic, and pyrogen free?

To avoid immune reactions and infections upon administration Signup and view all the answers

What distinguishes intradermal (ID) injections from subcutaneous (SC) injections in terms of drug administration?

Depth of penetration into the skin layers Signup and view all the answers

Which factor contributes to the unpredictable systemic drug concentrations after subcutaneous (SC) drug administration?

Drainage into the lymphatic system Signup and view all the answers

Why do drugs absorbed from the lungs avoid hepatic first-pass metabolism?

Due to direct entry into the systemic circulation Signup and view all the answers

How does drug absorption after intravenous (IV) administration differ from other routes?

Leads to immediate and direct systemic distribution Signup and view all the answers