Rosalind Franklin and DNA Structure
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Questions and Answers

What crucial piece of information did Photograph 51 reveal about the structure of DNA?

  • It demonstrated that DNA had a triple helix structure.
  • It showed that the backbone of the DNA molecule was on the interior.
  • It revealed the precise sequence of base pairs in DNA.
  • It confirmed the helical structure and double-stranded nature of DNA. (correct)

    • What was Rosalind Franklin's key contribution to understanding DNA?

  • Building the first 3D model of DNA.
  • Identifying the specific base pairing rules in DNA.
  • Developing the theoretical framework for DNA replication.
  • Capturing Photograph 51, which revealed the helical structure of DNA. (correct)

    • How was Maurice Wilkins involved in the discovery of DNA's structure?

  • He collaborated with Franklin, but shared her work without her knowledge. (correct)
  • He developed the X-ray diffraction techniques used by Franklin.
  • He played a primary role in interpreting Photograph 51 and deducing the double helix.
  • He independently confirmed Franklin's findings using different methods.

    • What was the primary contribution of Watson and Crick to the understanding of DNA?

    <p>Constructing a 3D model of DNA based in part on Franklin's findings. (D)</p> Signup and view all the answers

    In what year did Watson and Crick publish their DNA model?

    <p>1953 (D)</p> Signup and view all the answers

    What significant event related to DNA research occurred in 1958?

    <p>Rosalind Franklin passed away. (C)</p> Signup and view all the answers

    What was Rosalind Franklin's area of expertise?

    <p>X-ray diffraction (D)</p> Signup and view all the answers

    Which scientist received a Nobel Prize for research on DNA structure?

    <p>Maurice Wilkins (A)</p> Signup and view all the answers

    What did Franklin focus on after her work at King's College?

    <p>Studying the structure of viruses (A)</p> Signup and view all the answers

    When was the crystalline structure of the polio virus confirmed?

    <p>1959 (B)</p> Signup and view all the answers

    Flashcards

    Photograph 51

    The first clear image of the DNA structure taken by Rosalind Franklin using X-ray diffraction.

    Rosalind Franklin

    Key scientist who produced Photograph 51, revealing DNA's helical structure.

    Helical structure

    The spiral shape of DNA, identified through X-ray techniques.

    DNA backbone

    The exterior structure of DNA, proposed by Franklin, consisting of sugar and phosphate.

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    James Watson & Francis Crick

    Scientists who created a 3D model of DNA in 1953, inspired by Franklin’s work.

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    Maurice Wilkins

    Collaborated with Franklin and received a Nobel Prize, but shared Franklin’s work without her consent.

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    1952

    The year Rosalind Franklin produced Photograph 51.

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    Nobel Prize

    Award received by Wilkins, Watson, and Crick for DNA research.

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    Tobacco mosaic virus

    A virus that Franklin studied to produce a model of its crystalline structure.

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    Significance of Franklin's work

    Recognized posthumously for fundamentally influencing modern biology and understanding DNA structure.

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    Study Notes

    X-Ray Photographs of DNA

    • Photograph 51, taken in 1952, was the first clear image of DNA's crystalline structure
    • This image revealed DNA's helical (spiral) structure, composed of two strands
    • The photograph was taken by Rosalind Franklin
    • It took 60 hours to produce the X-ray image
    • Franklin's work was crucial in determining DNA's structure, but her contributions were not immediately recognized

    Rosalind Franklin's Contributions

    • Franklin refined X-ray techniques, leading to the clear image of DNA
    • She proposed that DNA's backbone lay outside the molecule
    • Her work on viruses, like the tobacco mosaic virus (TMV), demonstrated her skills in crystallography
    • She shifted to studying virus structure after 1953 at Birkbeck College

    Maurice Wilkins

    • Wilkins shared a Nobel Prize for the work on DNA structure, along with Crick and Watson
    • Wilkins used X-ray imaging to study DNA structure
    • He later became a professor at King's College

    Funding and Recognition

    • Rosalind Franklin received a grant of $13,000 to study the polio virus
    • She bequeathed $4,000 to a colleague (Aaron Klug)
    • Franklin's contributions were essential yet were not appropriately recognized during her lifetime

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    Description

    Test your knowledge on the significant contributions of Rosalind Franklin in the discovery of DNA's structure through X-ray photography. Learn about the critical moments surrounding Photograph 51 and how her work shaped modern genetics. Delve into the impact of her research and the recognition she received posthumously.

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