Role of CD47 in Phagocytosis and Immune Checkpoint
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Questions and Answers

What is the name of the syndrome associated with inflammasome mutations that features infantile enterocolitis?

  • Muckle-Wells syndrome (MWS)
  • NOMID
  • Autoinflammation with infantile enterocolitis (AIFEC) (correct)
  • Familial cold induced autoinflammatory syndrome (FCAS)

    • Which of the following diseases is NOT related to inflammasomes according to the text?

  • Parkinson (correct)
  • Amyloidosis
  • Alzheimer
  • Atherosclerosis

    • Which receptors are associated with the cGAS-STING pathway in innate immune recognition?

  • C-type lectin receptors (CLRs)
  • NLRs
  • Toll-like receptors (TLRs)
  • RLRs (correct)

    • What is the 'dirty little secret' of vaccines mentioned in the text?

    <p>Presence of adjuvants</p> Signup and view all the answers

    Which protein acts as the Mitochondrial Anti-Viral Signaling Protein for viral evasion strategies?

    <p>MAVS</p> Signup and view all the answers

    What are the main targets for viral interference with adaptive immunity highlighted in the text?

    <p>RLRs</p> Signup and view all the answers

    Which syndrome is NOT listed as an auto-inflammatory syndrome associated with inflammasome mutations?

    <p>NAIAD</p> Signup and view all the answers

    What is a characteristic feature of prokaryotic RNA that can be detected by TLR8 according to the text?

    <p>Cyclic dinucleotides</p> Signup and view all the answers

    What is detected by DNA/RNA-sensing PRRs that leads to IRF3/IRF7 activation according to the text?

    <p>Viral-derived RNA</p> Signup and view all the answers

    What is the name of the enzyme that is involved in IL-1 and IL-18 production?

    <p>ICE</p> Signup and view all the answers

    Which process involves the induction of pro-proteins followed by proteolytic cleavage?

    <p>Inflammasome activation</p> Signup and view all the answers

    Which molecule triggers pore formation allowing extracellular NLRP3 agonists to engage NLRP3?

    <p>ATP</p> Signup and view all the answers

    What is the primary function of alum (aluminium hydroxide) in vaccines?

    <p>Creating a depot for antigens</p> Signup and view all the answers

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