Role of CD47 in Phagocytosis and Immune Checkpoint
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Questions and Answers

What is the name of the syndrome associated with inflammasome mutations that features infantile enterocolitis?

  • Muckle-Wells syndrome (MWS)
  • NOMID
  • Autoinflammation with infantile enterocolitis (AIFEC) (correct)
  • Familial cold induced autoinflammatory syndrome (FCAS)

Which of the following diseases is NOT related to inflammasomes according to the text?

  • Parkinson (correct)
  • Amyloidosis
  • Alzheimer
  • Atherosclerosis

Which receptors are associated with the cGAS-STING pathway in innate immune recognition?

  • C-type lectin receptors (CLRs)
  • NLRs
  • Toll-like receptors (TLRs)
  • RLRs (correct)

What is the 'dirty little secret' of vaccines mentioned in the text?

<p>Presence of adjuvants (D)</p> Signup and view all the answers

Which protein acts as the Mitochondrial Anti-Viral Signaling Protein for viral evasion strategies?

<p>MAVS (D)</p> Signup and view all the answers

What are the main targets for viral interference with adaptive immunity highlighted in the text?

<p>RLRs (C)</p> Signup and view all the answers

Which syndrome is NOT listed as an auto-inflammatory syndrome associated with inflammasome mutations?

<p>NAIAD (B)</p> Signup and view all the answers

What is a characteristic feature of prokaryotic RNA that can be detected by TLR8 according to the text?

<p>Cyclic dinucleotides (D)</p> Signup and view all the answers

What is detected by DNA/RNA-sensing PRRs that leads to IRF3/IRF7 activation according to the text?

<p>Viral-derived RNA (A)</p> Signup and view all the answers

What is the name of the enzyme that is involved in IL-1 and IL-18 production?

<p>ICE (B)</p> Signup and view all the answers

Which process involves the induction of pro-proteins followed by proteolytic cleavage?

<p>Inflammasome activation (C)</p> Signup and view all the answers

Which molecule triggers pore formation allowing extracellular NLRP3 agonists to engage NLRP3?

<p>ATP (C)</p> Signup and view all the answers

What is the primary function of alum (aluminium hydroxide) in vaccines?

<p>Creating a depot for antigens (B)</p> Signup and view all the answers
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