13 Questions
What is the name of the syndrome associated with inflammasome mutations that features infantile enterocolitis?
Autoinflammation with infantile enterocolitis (AIFEC)
Which of the following diseases is NOT related to inflammasomes according to the text?
Parkinson
Which receptors are associated with the cGAS-STING pathway in innate immune recognition?
RLRs
What is the 'dirty little secret' of vaccines mentioned in the text?
Presence of adjuvants
Which protein acts as the Mitochondrial Anti-Viral Signaling Protein for viral evasion strategies?
MAVS
What are the main targets for viral interference with adaptive immunity highlighted in the text?
RLRs
Which syndrome is NOT listed as an auto-inflammatory syndrome associated with inflammasome mutations?
NAIAD
What is a characteristic feature of prokaryotic RNA that can be detected by TLR8 according to the text?
Cyclic dinucleotides
What is detected by DNA/RNA-sensing PRRs that leads to IRF3/IRF7 activation according to the text?
Viral-derived RNA
What is the name of the enzyme that is involved in IL-1 and IL-18 production?
ICE
Which process involves the induction of pro-proteins followed by proteolytic cleavage?
Inflammasome activation
Which molecule triggers pore formation allowing extracellular NLRP3 agonists to engage NLRP3?
ATP
What is the primary function of alum (aluminium hydroxide) in vaccines?
Creating a depot for antigens
Explore the significance of CD47 in the recognition and removal of dead cells by phagocytes, as well as its involvement in the 'don't eat me signal' mechanism to protect healthy cells. Learn about the CD47-SIRPα immune checkpoint and its relevance in cancer cell evasion from phagocytosis.
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