Rodak's Hematology: Hemostasis Part I Quiz

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Questions and Answers

Which of the following is a screening test for assessing deficiencies in factors II, V, VII, and X?

  • Platelet count
  • Prothrombin time (correct)
  • Partial thromboplastin time
  • Thrombin time

In which disorder is the platelet aggregation abnormal in response to ristocetin?

  • Bernard-Soulier syndrome (BSS)
  • Glanzmann's thrombasthenia
  • von Willebrand disease (VWD) (correct)
  • Storage pool defect

Which of the following is a hereditary coagulopathy that manifests during infancy or early in life?

  • Hemophilia A (correct)
  • Disseminated intravascular coagulation (DIC)
  • Vitamin K deficiency
  • Acquired hemophilia

In which disorder is clot retraction absent?

<p>Bernard-Soulier syndrome (BSS) (B)</p> Signup and view all the answers

Which of the following tests assesses for hypofibrinogenemia and dysfibrinogenemia?

<p>Thrombin time (A)</p> Signup and view all the answers

Which of the following is an acquired coagulopathy that manifests during adulthood?

<p>Disseminated intravascular coagulation (DIC) (C)</p> Signup and view all the answers

What is the main function of secondary hemostasis in the body?

<p>To reinforce the unstable platelet plug with chemically stable fibrin (A)</p> Signup and view all the answers

Which enzyme is responsible for transforming soluble fibrinogen to insoluble fibrin in secondary hemostasis?

<p>Thrombin (A)</p> Signup and view all the answers

What components are involved in determining the equilibrium between bleeding and clotting in hemostasis?

<p>Platelets, vascular endothelial cells, and coagulation proteins (B)</p> Signup and view all the answers

In secondary hemostasis, what is the role of thrombin?

<p>Generates fibrin from fibrinogen to stabilize the platelet plug (C)</p> Signup and view all the answers

Which phase of hemostasis involves clot (fibrin) dissolution and vessel repair?

<p>Primary hemostasis (B)</p> Signup and view all the answers

What is the endpoint of the enzyme-mediated reactions in secondary hemostasis?

<p>Generation of thrombin (C)</p> Signup and view all the answers

What is the usual clinical sign of vascular disorders?

<p>Tendency to bruise easily or bleed spontaneously (D)</p> Signup and view all the answers

Which laboratory studies are usually normal in patients with vascular disorders?

<p>Both platelets and blood coagulation (D)</p> Signup and view all the answers

What is the basis for diagnosing hereditary hemorrhagic telangiectasia?

<p>Family history of a similar disorder (D)</p> Signup and view all the answers

Which condition is characterized by obvious hemorrhages into the skin and mucous membranes?

<p>Purpura (D)</p> Signup and view all the answers

Which vascular disorder is associated with cherry-red hemangiomas, ataxia-telangiectasia, and chronic actinic telangiectasia?

<p>Hereditary hemorrhagic telangiectasia (A)</p> Signup and view all the answers

Flashcards

Prothrombin Time (PT)

Assesses deficiencies in factors II, V, VII, and X.

von Willebrand Disease (VWD)

Platelet aggregation is abnormal in response to Ristocetin

Hemophilia A

A hereditary coagulopathy manifesting in infancy or early life.

Bernard-Soulier Syndrome (BSS)

Absence of clot retraction.

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Thrombin Time (TT)

Assesses for hypofibrinogenemia and dysfibrinogenemia.

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Disseminated Intravascular Coagulation (DIC)

An acquired coagulopathy manifesting in adulthood.

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Main Function of Secondary Hemostasis

To reinforce the unstable platelet plug with chemically stable fibrin.

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Role of Thrombin

Transforms soluble fibrinogen to insoluble fibrin.

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Components Determining Hemostatic Equilibrium

Platelets, vascular endothelial cells, and coagulation proteins.

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Thrombin's Role in Secondary Hemostasis

Generates fibrin from fibrinogen to stabilize the platelet plug.

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Primary Hemostasis

Clot (fibrin) dissolution and vessel repair.

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Endpoint of Enzyme-Mediated Reactions in Secondary Hemostasis

Generation of thrombin.

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Clinical Sign of Vascular Disorders

Tendency to bruise easily or bleed spontaneously.

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Normal Lab Studies in Vascular Disorders

Both platelets and blood coagulation.

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Diagnosing Hereditary Hemorrhagic Telangiectasia

Family history of a similar disorder.

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Purpura

Obvious hemorrhages into the skin and mucous membranes.

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Hereditary Hemorrhagic Telangiectasia

Cherry-red hemangiomas, ataxia-telangiectasia, and chronic actinic telangiectasia.

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