17 Questions
Which of the following is a screening test for assessing deficiencies in factors II, V, VII, and X?
Prothrombin time
In which disorder is the platelet aggregation abnormal in response to ristocetin?
von Willebrand disease (VWD)
Which of the following is a hereditary coagulopathy that manifests during infancy or early in life?
Hemophilia A
In which disorder is clot retraction absent?
Bernard-Soulier syndrome (BSS)
Which of the following tests assesses for hypofibrinogenemia and dysfibrinogenemia?
Thrombin time
Which of the following is an acquired coagulopathy that manifests during adulthood?
Disseminated intravascular coagulation (DIC)
What is the main function of secondary hemostasis in the body?
To reinforce the unstable platelet plug with chemically stable fibrin
Which enzyme is responsible for transforming soluble fibrinogen to insoluble fibrin in secondary hemostasis?
Thrombin
What components are involved in determining the equilibrium between bleeding and clotting in hemostasis?
Platelets, vascular endothelial cells, and coagulation proteins
In secondary hemostasis, what is the role of thrombin?
Generates fibrin from fibrinogen to stabilize the platelet plug
Which phase of hemostasis involves clot (fibrin) dissolution and vessel repair?
Primary hemostasis
What is the endpoint of the enzyme-mediated reactions in secondary hemostasis?
Generation of thrombin
What is the usual clinical sign of vascular disorders?
Tendency to bruise easily or bleed spontaneously
Which laboratory studies are usually normal in patients with vascular disorders?
Both platelets and blood coagulation
What is the basis for diagnosing hereditary hemorrhagic telangiectasia?
Family history of a similar disorder
Which condition is characterized by obvious hemorrhages into the skin and mucous membranes?
Purpura
Which vascular disorder is associated with cherry-red hemangiomas, ataxia-telangiectasia, and chronic actinic telangiectasia?
Hereditary hemorrhagic telangiectasia
Test your knowledge on secondary hemostasis principles and applications based on the concepts covered in the lecture by Mr. Raphael Enrique G. Tiongco. Questions are derived from 'Rodak’s Hematology: Clinical Principles and Applications' by Keohane, E., Smith, L., & Walenga, J. (2019).
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