Podcast
Questions and Answers
What is the therapeutic class of Rocephin (ceftriaxone)?
What is the therapeutic class of Rocephin (ceftriaxone)?
- Antipyretics
- Antivirals
- Analgesics
- Anti-infectives (correct)
What pharmacologic class does Rocephin (ceftriaxone) belong to?
What pharmacologic class does Rocephin (ceftriaxone) belong to?
- Third generation cephalosporins (correct)
- First generation cephalosporins
- Second generation cephalosporins
- Macrolides
List some indications for Rocephin (ceftriaxone).
List some indications for Rocephin (ceftriaxone).
Treatment of skin and skin structure infections, bone and joint infections, complicated and uncomplicated UTI, uncomplicated gynecological infections including gonorrhea, lower respiratory tract infections, intra-abdominal infections, septicemia, meningitis, otitis media, and perioperative prophylaxis.
What is the mechanism of action (MOA) of Rocephin (ceftriaxone)?
What is the mechanism of action (MOA) of Rocephin (ceftriaxone)?
What is the therapeutic effect of Rocephin (ceftriaxone)?
What is the therapeutic effect of Rocephin (ceftriaxone)?
What assessments should be made for a patient receiving Rocephin (ceftriaxone)?
What assessments should be made for a patient receiving Rocephin (ceftriaxone)?
What laboratory results may occur with Rocephin (ceftriaxone) use?
What laboratory results may occur with Rocephin (ceftriaxone) use?
What should patients be taught regarding Rocephin (ceftriaxone)?
What should patients be taught regarding Rocephin (ceftriaxone)?
What are some side effects of Rocephin (ceftriaxone)?
What are some side effects of Rocephin (ceftriaxone)?
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Study Notes
Rocephin (ceftriaxone) Overview
- Rocephin is classified as an anti-infective, used to treat various bacterial infections.
- It belongs to the third generation of cephalosporins, offering broad-spectrum coverage.
Indications for Use
- Effective against a range of infections, including:
- Skin and skin structure infections
- Bone and joint infections
- Both complicated and uncomplicated urinary tract infections (UTIs)
- Uncomplicated gynecological infections, notably gonorrhea
- Lower respiratory tract infections
- Intra-abdominal infections
- Septicemia and meningitis
- Otitis media
- Used for perioperative prophylaxis to prevent surgical infections
Mechanism of Action
- Works by binding to the bacterial cell wall membrane, leading to cell death and bactericidal effects.
Therapeutic Effects
- Exhibits a strong bactericidal action against susceptible bacteria, making it effective for serious infections.
Assessment Prior to Administration
- Monitor vital signs, wound appearance, sputum, urine, and stool for signs of infection.
- Check for history of allergic reactions to penicillin or cephalosporins, along with signs of anaphylaxis.
- Evaluate bowel function; report any signs of Clostridium difficile-associated colitis such as diarrhea and abdominal cramping.
Laboratory Considerations
- May lead to false positives in Coombs' test.
- Can cause increased levels of liver enzymes (AST, ALT), alkaline phosphatase, bilirubin, LDH, BUN, and creatinine.
- Rarely associated with blood disorders like leukopenia and thrombocytopenia.
Patient Education
- Instruct patients to report any signs of superinfection, such as unusual growth in the mouth or changes in bowel habits.
- Advise to notify healthcare provider if fever or diarrhea develops, especially if accompanied by blood or mucus.
Side Effects
- Serious, though rare, side effects include anaphylaxis, seizures, and Clostridium difficile-associated diarrhea (CDAD).
- Common side effects may include pain at the IM injection site and phlebitis at the IV site.
- Other potential issues involve acute renal failure and bleeding complications.
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