Podcast
Questions and Answers
What is the primary function of Micro RNA (miRNA)?
What is the primary function of Micro RNA (miRNA)?
- To synthesise protein molecules
- To regulate endogenous gene expression (correct)
- To regulate exogenous gene expression
- To activate RNAi silencing pathway
What is the role of Drosha in miRNA biogenesis?
What is the role of Drosha in miRNA biogenesis?
- To export pre-miRNA to the cytoplasm
- To cleave pri-miRNA to produce pre-miRNA (correct)
- To cleave the terminal loop of pre-miRNA
- To bind to the double-stranded RNA binding protein DGCR8
What is the function of Exportin 5 in miRNA biogenesis?
What is the function of Exportin 5 in miRNA biogenesis?
- To bind to pre-miRNA and transport it to the cytoplasm (correct)
- To cleave pri-miRNA to produce pre-miRNA
- To bind to the double-stranded RNA binding protein DGCR8
- To select the guide strand of miRNA
What is the role of Dicer in miRNA biogenesis?
What is the role of Dicer in miRNA biogenesis?
What is the function of the RISC loading complex?
What is the function of the RISC loading complex?
What is the mechanism of miRNA-mediated gene regulation?
What is the mechanism of miRNA-mediated gene regulation?
What is the characteristic of RNAase III enzymes?
What is the characteristic of RNAase III enzymes?
What is the purpose of miRNA sequencing?
What is the purpose of miRNA sequencing?
What is the consequence of a mutation in miR-96?
What is the consequence of a mutation in miR-96?
What is the potential application of RNAi in therapy?
What is the potential application of RNAi in therapy?
What is the primary site of pre-miRNA processing?
What is the primary site of pre-miRNA processing?
Which complex is responsible for the cleavage of pri-miRNA?
Which complex is responsible for the cleavage of pri-miRNA?
What is the purpose of the double-stranded RNA-binding domain (dsRBD) in RNAase III enzymes?
What is the purpose of the double-stranded RNA-binding domain (dsRBD) in RNAase III enzymes?
What is the consequence of a mutation in miR-184?
What is the consequence of a mutation in miR-184?
What is the function of TRBP in miRNA biogenesis?
What is the function of TRBP in miRNA biogenesis?
What is the purpose of miRNA sequencing?
What is the purpose of miRNA sequencing?
Which of the following is NOT a characteristic of RNAase III enzymes?
Which of the following is NOT a characteristic of RNAase III enzymes?
What is the purpose of the RISC loading complex?
What is the purpose of the RISC loading complex?
What is the consequence of down-regulating VEGF using siRNA?
What is the consequence of down-regulating VEGF using siRNA?
What is the function of Exportin 5 in miRNA biogenesis?
What is the function of Exportin 5 in miRNA biogenesis?
Which of the following is a characteristic of Class I RNAase III enzymes?
Which of the following is a characteristic of Class I RNAase III enzymes?
What is the purpose of the microprocessor complex in miRNA biogenesis?
What is the purpose of the microprocessor complex in miRNA biogenesis?
What is the function of the passenger strand in the RISC loading complex?
What is the function of the passenger strand in the RISC loading complex?
What is the consequence of a mutation in the DICER gene?
What is the consequence of a mutation in the DICER gene?
What is the purpose of miRNA arrays?
What is the purpose of miRNA arrays?
How does miRNA-mediated gene regulation occur?
How does miRNA-mediated gene regulation occur?
What is the function of the double-stranded RNA-binding domain (dsRBD) in RNAase III enzymes?
What is the function of the double-stranded RNA-binding domain (dsRBD) in RNAase III enzymes?
What is the consequence of injecting siRNA that down-regulates VEGF into the eye?
What is the consequence of injecting siRNA that down-regulates VEGF into the eye?
What is the function of TRBP in miRNA biogenesis?
What is the function of TRBP in miRNA biogenesis?
What is the characteristic of the RISC loading complex?
What is the characteristic of the RISC loading complex?