Rivaroxaban Flashcards

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Questions and Answers

What is the trade name for rivaroxaban?

Aspirin

Dabigatran

Warfarin

Xarelto (correct)

What is the classification of rivaroxaban?

Anticoagulant

What is the mechanism of action for rivaroxaban?

Direct Xa inhibitor/antagonist

How does rivaroxaban work?

Bind directly with the active center of factor Xa and thereby inhibits production of thrombin Signup and view all the answers

What are the indications for the use of rivaroxaban?

Deep vein thrombosis and pulmonary embolism Signup and view all the answers

What does DVT stand for?

Deep vein thrombosis Signup and view all the answers

What does PE stand for?

Pulmonary embolism Signup and view all the answers

What precautions should be taken with rivaroxaban?

Renal impairment, hepatic impairment, and pregnancy Signup and view all the answers

What is the risk associated with renal impairment and rivaroxaban?

Can delay excretion of rivaroxaban and increase the risk of bleeding Signup and view all the answers

Why should rivaroxaban not be used in patients with hepatic impairment?

It should not be used in people with moderate to severe hepatic impairment Signup and view all the answers

What are some risks of using rivaroxaban during pregnancy?

Increased risk of pregnancy-related hemorrhage and may have detrimental effects on the fetus Signup and view all the answers

What are the advantages of rivaroxaban over warfarin?

All of the above Signup and view all the answers

What should patients taking rivaroxaban be monitored for?

Signs of bleeding Signup and view all the answers

What are some drug interactions with rivaroxaban?

Dabigatran, aspirin, warfarin, fluoxetine Signup and view all the answers

What is the effect of taking dabigatran and rivaroxaban together?

Increase the risk of bleeding including sometimes fatal hemorrhage Signup and view all the answers

What is the effect of taking aspirin and rivaroxaban together?

Increase risk of bleeding including fatal hemorrhage Signup and view all the answers

What is the effect of taking warfarin and rivaroxaban together?

Increased risk of bleeding including sometimes fatal hemorrhage Signup and view all the answers

What is the effect of fluoxetine and rivaroxaban?

May increase risk of bleeding, bigger if elderly or have kidney or liver disease Signup and view all the answers

What are some adverse drug reactions to rivaroxaban?

Bleeding and spinal/epidural hematoma Signup and view all the answers

Study Notes

Rivaroxaban Overview

Trade name: Xarelto
Classification: Anticoagulant

Mechanism of Action

Acts as a direct Xa inhibitor, blocking Factor Xa activity.
Inhibits thrombin production by binding at the active site of Factor Xa.

Indications for Use

Approved for treating Deep Vein Thrombosis (DVT).
Used in the management of Pulmonary Embolism (PE).

Key Terms

DVT stands for Deep Vein Thrombosis.
PE stands for Pulmonary Embolism.

Precautions

Caution in patients with renal impairment, hepatic impairment, and those who are pregnant.
Renal impairment may delay the drug's excretion, increasing bleeding risks.
Not recommended for individuals with moderate to severe hepatic impairment.
Increased risk of pregnancy-related hemorrhage and possible fetal harm.

Advantages Over Warfarin

Rapid onset of action.
Fixed dosing regimen without the need for INR monitoring.
Lower risk of bleeding complications.
Fewer drug interactions compared to warfarin.

Monitoring Requirements

Patients on rivaroxaban should be monitored for signs of bleeding, which can occur due to its anticoagulant effects.

Drug Interactions

Significant interactions with dabigatran, aspirin, warfarin, and fluoxetine.
Combining dabigatran with rivaroxaban heightens bleeding risks, potentially leading to fatal hemorrhages.
Concurrent use of aspirin or warfarin similarly raises bleeding risk.
Fluoxetine can increase bleeding risk, especially in elderly patients or those with renal or liver disease.

Adverse Drug Reactions

Common adverse effects include bleeding events.
Risk of spinal or epidural hematoma is a serious concern.

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Description

Test your knowledge on rivaroxaban with these flashcards. Covering its trade name, classification, mechanism of action, and indications for use, this quiz will enhance your understanding of this important anticoagulant. Perfect for students and professionals in healthcare fields.