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Questions and Answers
What is the trade name for rivaroxaban?
What is the trade name for rivaroxaban?
- Aspirin
- Dabigatran
- Warfarin
- Xarelto (correct)
What is the classification of rivaroxaban?
What is the classification of rivaroxaban?
Anticoagulant
What is the mechanism of action for rivaroxaban?
What is the mechanism of action for rivaroxaban?
Direct Xa inhibitor/antagonist
How does rivaroxaban work?
How does rivaroxaban work?
What are the indications for the use of rivaroxaban?
What are the indications for the use of rivaroxaban?
What does DVT stand for?
What does DVT stand for?
What does PE stand for?
What does PE stand for?
What precautions should be taken with rivaroxaban?
What precautions should be taken with rivaroxaban?
What is the risk associated with renal impairment and rivaroxaban?
What is the risk associated with renal impairment and rivaroxaban?
Why should rivaroxaban not be used in patients with hepatic impairment?
Why should rivaroxaban not be used in patients with hepatic impairment?
What are some risks of using rivaroxaban during pregnancy?
What are some risks of using rivaroxaban during pregnancy?
What are the advantages of rivaroxaban over warfarin?
What are the advantages of rivaroxaban over warfarin?
What should patients taking rivaroxaban be monitored for?
What should patients taking rivaroxaban be monitored for?
What are some drug interactions with rivaroxaban?
What are some drug interactions with rivaroxaban?
What is the effect of taking dabigatran and rivaroxaban together?
What is the effect of taking dabigatran and rivaroxaban together?
What is the effect of taking aspirin and rivaroxaban together?
What is the effect of taking aspirin and rivaroxaban together?
What is the effect of taking warfarin and rivaroxaban together?
What is the effect of taking warfarin and rivaroxaban together?
What is the effect of fluoxetine and rivaroxaban?
What is the effect of fluoxetine and rivaroxaban?
What are some adverse drug reactions to rivaroxaban?
What are some adverse drug reactions to rivaroxaban?
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Study Notes
Rivaroxaban Overview
- Trade name: Xarelto
- Classification: Anticoagulant
Mechanism of Action
- Acts as a direct Xa inhibitor, blocking Factor Xa activity.
- Inhibits thrombin production by binding at the active site of Factor Xa.
Indications for Use
- Approved for treating Deep Vein Thrombosis (DVT).
- Used in the management of Pulmonary Embolism (PE).
Key Terms
- DVT stands for Deep Vein Thrombosis.
- PE stands for Pulmonary Embolism.
Precautions
- Caution in patients with renal impairment, hepatic impairment, and those who are pregnant.
- Renal impairment may delay the drug's excretion, increasing bleeding risks.
- Not recommended for individuals with moderate to severe hepatic impairment.
- Increased risk of pregnancy-related hemorrhage and possible fetal harm.
Advantages Over Warfarin
- Rapid onset of action.
- Fixed dosing regimen without the need for INR monitoring.
- Lower risk of bleeding complications.
- Fewer drug interactions compared to warfarin.
Monitoring Requirements
- Patients on rivaroxaban should be monitored for signs of bleeding, which can occur due to its anticoagulant effects.
Drug Interactions
- Significant interactions with dabigatran, aspirin, warfarin, and fluoxetine.
- Combining dabigatran with rivaroxaban heightens bleeding risks, potentially leading to fatal hemorrhages.
- Concurrent use of aspirin or warfarin similarly raises bleeding risk.
- Fluoxetine can increase bleeding risk, especially in elderly patients or those with renal or liver disease.
Adverse Drug Reactions
- Common adverse effects include bleeding events.
- Risk of spinal or epidural hematoma is a serious concern.
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