5 Questions
How is Rhinovirus typically transmitted?
Through inhalation of acid labile virus
What is the optimal temperature for Rhinovirus growth?
33°C
Why is it difficult to develop a vaccine against Rhinovirus?
Because it has a large number of serotypes
What is the primary mechanism by which Rhinovirus enters host cells?
By attaching to I-CAM1
What is the best way to prevent the spread of Rhinovirus?
Washing hands and disinfecting contaminated objects
Study Notes
Rhinovirus Structure and Characteristics
- Rhinovirus is a positive sense single-stranded RNA virus.
- It is a small pico virus.
Transmission and Prevention
- Rhinovirus is transmitted via inhalation, as it is acid labile.
- It can also be transmitted through fomites, which highlights the importance of washing hands.
- Handwashing and disinfection of contaminated objects are the best means of preventing the spread of the virus.
Mechanism of Infection
- Rhinovirus attaches to ICAM-1 to enter host cells.
Optimal Environment
- Rhinovirus grows best in the upper respiratory tract at a temperature of around 33°C.
- It needs to be kept at a cool temperature to thrive.
Clinical Significance
- Rhinovirus is the most common cause of the common cold and upper respiratory tract infections.
- There are a ridiculous number of serotypes, with 113 total, which makes it challenging to develop a vaccine.
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