Podcast
Questions and Answers
What type of modification occurs to arginine residues in citrullinated peptides?
What type of modification occurs to arginine residues in citrullinated peptides?
- Citrullination (correct)
- Deamination
- Phosphorylation
- Methylation
What are autoantibodies in Rheumatoid Arthritis primarily directed against?
What are autoantibodies in Rheumatoid Arthritis primarily directed against?
- Glycated peptides
- Modified citrullinated peptides (correct)
- Native peptides
- Oxidized peptides
What is the significance of citrullination in Rheumatoid Arthritis?
What is the significance of citrullination in Rheumatoid Arthritis?
- It is involved in antigen presentation
- It is a post-translational modification in citrullinated peptides (correct)
- It promotes inflammation
- It reduces immune response
What is the target of autoantibodies in Rheumatoid Arthritis?
What is the target of autoantibodies in Rheumatoid Arthritis?
What is the role of post-translational modifications in Rheumatoid Arthritis?
What is the role of post-translational modifications in Rheumatoid Arthritis?
What type of cells predominantly secrete cytokines that induce inflammation in RA?
What type of cells predominantly secrete cytokines that induce inflammation in RA?
What is a hallmark of autoimmune diseases like RA?
What is a hallmark of autoimmune diseases like RA?
What contributes to the pathogenesis of RA?
What contributes to the pathogenesis of RA?
Which of the following is NOT a characteristic feature of RA?
Which of the following is NOT a characteristic feature of RA?
Which type of cells play a crucial role in the pathogenesis of RA?
Which type of cells play a crucial role in the pathogenesis of RA?
What is the approximate percentage of RA patients in which ACPAs are detected in their serum?
What is the approximate percentage of RA patients in which ACPAs are detected in their serum?
What is the primary function of ACPAs in the diagnosis of RA?
What is the primary function of ACPAs in the diagnosis of RA?
In what bodily fluid are ACPAs typically detected?
In what bodily fluid are ACPAs typically detected?
What type of antibodies are ACPAs?
What type of antibodies are ACPAs?
What is the disease associated with the presence of ACPAs?
What is the disease associated with the presence of ACPAs?
Study Notes
Rheumatoid Arthritis (RA) Diagnostic Markers
- Anti-citrullinated peptide antibodies (ACPAs) are detected in serum of up to 70% of RA patients.
- ACPAs are involved in autoantibody production against citrullinated peptides (CCPs).
Characteristics of Autoantibodies in RA
- Autoantibodies are produced against self-antigens.
- Autoantibodies are triggered by inflammation induced by cytokines.
- Cytokines are predominantly secreted by CD4+ T cells.
- Arginine residues are post-translationally converted to citrulline in citrullinated peptides.
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Description
This quiz covers the diagnostic markers for Rheumatoid Arthritis (RA), including Anti-Citrullinated Peptide Antibodies (ACPAs). ACPAs are detected in the serum of up to 70% of RA patients. Test your knowledge of RA diagnosis and treatment.
