15 Questions
What type of modification occurs to arginine residues in citrullinated peptides?
Citrullination
What are autoantibodies in Rheumatoid Arthritis primarily directed against?
Modified citrullinated peptides
What is the significance of citrullination in Rheumatoid Arthritis?
It is a post-translational modification in citrullinated peptides
What is the target of autoantibodies in Rheumatoid Arthritis?
Citrullinated peptides
What is the role of post-translational modifications in Rheumatoid Arthritis?
They modify antigens
What type of cells predominantly secrete cytokines that induce inflammation in RA?
CD4+ T cells
What is a hallmark of autoimmune diseases like RA?
Autoantibodies against self antigens
What contributes to the pathogenesis of RA?
Autoantibodies against self antigens and inflammation induced by chemokines
Which of the following is NOT a characteristic feature of RA?
Cytokine imbalance in favor of anti-inflammatory cytokines
Which type of cells play a crucial role in the pathogenesis of RA?
CD4+ T cells
What is the approximate percentage of RA patients in which ACPAs are detected in their serum?
70%
What is the primary function of ACPAs in the diagnosis of RA?
To detect the presence of RA
In what bodily fluid are ACPAs typically detected?
Serum
What type of antibodies are ACPAs?
Autoantibodies
What is the disease associated with the presence of ACPAs?
Rheumatoid Arthritis
Study Notes
Rheumatoid Arthritis (RA) Diagnostic Markers
- Anti-citrullinated peptide antibodies (ACPAs) are detected in serum of up to 70% of RA patients.
- ACPAs are involved in autoantibody production against citrullinated peptides (CCPs).
Characteristics of Autoantibodies in RA
- Autoantibodies are produced against self-antigens.
- Autoantibodies are triggered by inflammation induced by cytokines.
- Cytokines are predominantly secreted by CD4+ T cells.
- Arginine residues are post-translationally converted to citrulline in citrullinated peptides.
This quiz covers the diagnostic markers for Rheumatoid Arthritis (RA), including Anti-Citrullinated Peptide Antibodies (ACPAs). ACPAs are detected in the serum of up to 70% of RA patients. Test your knowledge of RA diagnosis and treatment.
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