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Rheumatoid Arthritis Diagnostic Markers

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Questions and Answers

What type of modification occurs to arginine residues in citrullinated peptides?

Citrullination (correct)

Deamination

Phosphorylation

Methylation

What are autoantibodies in Rheumatoid Arthritis primarily directed against?

Glycated peptides

Modified citrullinated peptides (correct)

Native peptides

Oxidized peptides

What is the significance of citrullination in Rheumatoid Arthritis?

It is involved in antigen presentation

It is a post-translational modification in citrullinated peptides (correct)

It promotes inflammation

It reduces immune response

What is the target of autoantibodies in Rheumatoid Arthritis?

Citrullinated peptides Signup and view all the answers

What is the role of post-translational modifications in Rheumatoid Arthritis?

They modify antigens Signup and view all the answers

What type of cells predominantly secrete cytokines that induce inflammation in RA?

CD4+ T cells Signup and view all the answers

What is a hallmark of autoimmune diseases like RA?

Autoantibodies against self antigens Signup and view all the answers

What contributes to the pathogenesis of RA?

Autoantibodies against self antigens and inflammation induced by chemokines Signup and view all the answers

Which of the following is NOT a characteristic feature of RA?

Cytokine imbalance in favor of anti-inflammatory cytokines Signup and view all the answers

Which type of cells play a crucial role in the pathogenesis of RA?

CD4+ T cells Signup and view all the answers

What is the approximate percentage of RA patients in which ACPAs are detected in their serum?

70% Signup and view all the answers

What is the primary function of ACPAs in the diagnosis of RA?

To detect the presence of RA Signup and view all the answers

In what bodily fluid are ACPAs typically detected?

Serum Signup and view all the answers

What type of antibodies are ACPAs?

Autoantibodies Signup and view all the answers

What is the disease associated with the presence of ACPAs?

Rheumatoid Arthritis Signup and view all the answers

Study Notes

Rheumatoid Arthritis (RA) Diagnostic Markers

Anti-citrullinated peptide antibodies (ACPAs) are detected in serum of up to 70% of RA patients.
ACPAs are involved in autoantibody production against citrullinated peptides (CCPs).

Characteristics of Autoantibodies in RA

Autoantibodies are produced against self-antigens.
Autoantibodies are triggered by inflammation induced by cytokines.
Cytokines are predominantly secreted by CD4+ T cells.
Arginine residues are post-translationally converted to citrulline in citrullinated peptides.

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Description

This quiz covers the diagnostic markers for Rheumatoid Arthritis (RA), including Anti-Citrullinated Peptide Antibodies (ACPAs). ACPAs are detected in the serum of up to 70% of RA patients. Test your knowledge of RA diagnosis and treatment.