Rheumatoid Arthritis Diagnostic Markers
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Questions and Answers

What type of modification occurs to arginine residues in citrullinated peptides?

  • Citrullination (correct)
  • Deamination
  • Phosphorylation
  • Methylation
  • What are autoantibodies in Rheumatoid Arthritis primarily directed against?

  • Glycated peptides
  • Modified citrullinated peptides (correct)
  • Native peptides
  • Oxidized peptides
  • What is the significance of citrullination in Rheumatoid Arthritis?

  • It is involved in antigen presentation
  • It is a post-translational modification in citrullinated peptides (correct)
  • It promotes inflammation
  • It reduces immune response
  • What is the target of autoantibodies in Rheumatoid Arthritis?

    <p>Citrullinated peptides</p> Signup and view all the answers

    What is the role of post-translational modifications in Rheumatoid Arthritis?

    <p>They modify antigens</p> Signup and view all the answers

    What type of cells predominantly secrete cytokines that induce inflammation in RA?

    <p>CD4+ T cells</p> Signup and view all the answers

    What is a hallmark of autoimmune diseases like RA?

    <p>Autoantibodies against self antigens</p> Signup and view all the answers

    What contributes to the pathogenesis of RA?

    <p>Autoantibodies against self antigens and inflammation induced by chemokines</p> Signup and view all the answers

    Which of the following is NOT a characteristic feature of RA?

    <p>Cytokine imbalance in favor of anti-inflammatory cytokines</p> Signup and view all the answers

    Which type of cells play a crucial role in the pathogenesis of RA?

    <p>CD4+ T cells</p> Signup and view all the answers

    What is the approximate percentage of RA patients in which ACPAs are detected in their serum?

    <p>70%</p> Signup and view all the answers

    What is the primary function of ACPAs in the diagnosis of RA?

    <p>To detect the presence of RA</p> Signup and view all the answers

    In what bodily fluid are ACPAs typically detected?

    <p>Serum</p> Signup and view all the answers

    What type of antibodies are ACPAs?

    <p>Autoantibodies</p> Signup and view all the answers

    What is the disease associated with the presence of ACPAs?

    <p>Rheumatoid Arthritis</p> Signup and view all the answers

    Study Notes

    Rheumatoid Arthritis (RA) Diagnostic Markers

    • Anti-citrullinated peptide antibodies (ACPAs) are detected in serum of up to 70% of RA patients.
    • ACPAs are involved in autoantibody production against citrullinated peptides (CCPs).

    Characteristics of Autoantibodies in RA

    • Autoantibodies are produced against self-antigens.
    • Autoantibodies are triggered by inflammation induced by cytokines.
    • Cytokines are predominantly secreted by CD4+ T cells.
    • Arginine residues are post-translationally converted to citrulline in citrullinated peptides.

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    Description

    This quiz covers the diagnostic markers for Rheumatoid Arthritis (RA), including Anti-Citrullinated Peptide Antibodies (ACPAs). ACPAs are detected in the serum of up to 70% of RA patients. Test your knowledge of RA diagnosis and treatment.

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