Rheumatic Diseases Quiz
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Questions and Answers

What is the complication of gouty arthritis?

  • Group A streptococcal infection
  • Inadequate renal excretion of uric acid (correct)
  • Autoimmune destruction of joint collagen
  • Excessive production of urea

    • What is a clinical finding consistent with a diagnosis of rheumatoid arthritis?

  • Localized pain in weight-bearing joints
  • Reduced excretion of uric acid by the kidney
  • Firm, crystallized nodules or 'tophi' at the affected joints
  • Systemic manifestations of inflammation (correct)

    • What does the presence of rheumatoid factor autoantibodies indicate about rheumatoid arthritis?

  • An infective process
  • An autoimmune process (correct)
  • Caused by bacterial infection
  • Because of an enzymatic defect

    • What is the cause of gouty arthritis?

    <p>Inadequate renal excretion of uric acid</p> Signup and view all the answers

    What causes firm, crystallized nodules or 'tophi' at the affected joints?

    <p>Gout</p> Signup and view all the answers

    What is the clinical finding consistent with rheumatoid arthritis?

    <p>Systemic manifestations of inflammation</p> Signup and view all the answers

    What is not a causative factor in rheumatoid arthritis?

    <p>Uric acid</p> Signup and view all the answers

    What is the causative factor in gouty arthritis?

    <p>Inadequate renal excretion of uric acid</p> Signup and view all the answers

    What is the likely cause of rheumatoid arthritis?

    <p>Autoimmune process</p> Signup and view all the answers

    What is the cause of firm, crystallized nodules or 'tophi' at the affected joints?

    <p>Gout</p> Signup and view all the answers

    What is a clinical finding consistent with rheumatoid arthritis?

    <p>Systemic manifestations of inflammation</p> Signup and view all the answers

    What is not a causative factor in rheumatoid arthritis?

    <p>Uric acid</p> Signup and view all the answers

    What is the classic presentation of systemic lupus erythematosus (SLE)?

    <p>A butterfly pattern rash on the face</p> Signup and view all the answers

    What is the earliest manifestation of scleroderma?

    <p>Raynaud phenomenon with blanching of the digits in response to cold</p> Signup and view all the answers

    What is the most common presenting sign/symptom with rheumatic fever?

    <p>Polyarthritis</p> Signup and view all the answers

    What is ankylosing spondylitis characterized by?

    <p>Inflammation, stiffness, and fusion of spinal joints</p> Signup and view all the answers

    What does a positive antinuclear antibody test help confirm the diagnosis of?

    <p>Systemic lupus erythematosus (SLE)</p> Signup and view all the answers

    What is rheumatoid factor autoantibodies not indicative of?

    <p>Infection, infective process, or enzymatic defect</p> Signup and view all the answers

    What is rheumatoid arthritis associated with?

    <p>Systemic aching in the musculoskeletal system, debilitating joint pain and stiffness, and changes in daily activities</p> Signup and view all the answers

    What does prosthetic joint infection often result from?

    <p>Bacterial spread to the joint via the bloodstream</p> Signup and view all the answers

    What is systemic lupus erythematosus (SLE) attributed to?

    <p>Autoimmune mechanisms</p> Signup and view all the answers

    What should patients with SLE avoid to prevent the progression of cutaneous lesions?

    <p>Sun exposure</p> Signup and view all the answers

    What does scleroderma involve?

    <p>Fibrosis of connective tissue</p> Signup and view all the answers

    Which of the following is a characteristic of nonarticular rheumatism ('growing pain')?

    <p>During the night</p> Signup and view all the answers

    What causes rheumatoid arthritis?

    <p>Autoimmune injury</p> Signup and view all the answers

    Which of the following is a systemic disorder?

    <p>Rheumatoid arthritis</p> Signup and view all the answers

    What are tophi in the context of gout?

    <p>Deposits of urate crystals in tissues</p> Signup and view all the answers

    Which of the following is a characteristic of ankylosing spondylitis?

    <p>Presents with bamboo spine</p> Signup and view all the answers

    What is the cause of scleroderma?

    <p>Excessive collagen deposition in skin and organs</p> Signup and view all the answers

    What is the classic presentation of systemic lupus erythematosus (SLE)?

    <p>Butterfly rash and joint pain</p> Signup and view all the answers

    What is the causative factor in gouty arthritis?

    <p>Deposits of urate crystals in tissues</p> Signup and view all the answers

    What does adhesive capsulitis involve?

    <p>Painful restriction of shoulder movement</p> Signup and view all the answers

    What is the complication of gouty arthritis?

    <p>Tophi formation</p> Signup and view all the answers

    What is not a systemic disease?

    <p>Osteoarthritis</p> Signup and view all the answers

    What is the likely cause of rheumatoid arthritis?

    <p>Autoimmune injury to synovial joints</p> Signup and view all the answers

    Which condition involves the accumulation of immune cells in pannus and destruction of articular cartilage?

    <p>Rheumatoid arthritis</p> Signup and view all the answers

    What is the final chronic stage of gout characterized by crystalline deposits in cartilage, synovial membranes, and soft tissue called?

    <p>Tophaceous gout</p> Signup and view all the answers

    Which condition causes joint fibrosis, ossification, and fusion, most commonly of the intervertebral and sacroiliac joints?

    <p>Ankylosing spondylitis</p> Signup and view all the answers

    What are the chief pathologic features of osteoarthritis?

    <p>Degeneration of articular cartilage</p> Signup and view all the answers

    What is a characteristic manifestation of osteoarthritis?

    <p>Crepitus with joint movement</p> Signup and view all the answers

    What is the likely cause of gout?

    <p>Formation of uric acid crystals in joints</p> Signup and view all the answers

    What is a characteristic of gout?

    <p>Cardiac and renal involvement</p> Signup and view all the answers

    What are the manifestations of ankylosing spondylitis?

    <p>Instability of synovial joints</p> Signup and view all the answers

    What is a characteristic finding in Lyme disease?

    <p>Migratory rash</p> Signup and view all the answers

    What is the earliest stage of gout?

    <p>Asymptomatic hyperuricemia</p> Signup and view all the answers

    What is the pain pattern in osteoarthritis?

    <p>Worse with activity and relieved with rest</p> Signup and view all the answers

    What is a characteristic feature of gouty arthritis?

    <p>Nodules on joints of the hands</p> Signup and view all the answers

    Study Notes

    Rheumatic Diseases and Their Characteristics

    • Rheumatoid factor autoantibodies do not indicate infection, infective process, or enzymatic defect.
    • Rheumatoid arthritis is associated with systemic aching in the musculoskeletal system, debilitating joint pain and stiffness, and changes in daily activities.
    • Systemic lupus erythematosus (SLE) is attributed to autoimmune mechanisms, not wear and tear on weight-bearing joints or septic joint inflammation.
    • SLE leads to numerous complications due to immune injury to basement membranes.
    • A positive antinuclear antibody test helps confirm the diagnosis of SLE.
    • Patients with SLE should avoid sun exposure to prevent the progression of cutaneous lesions.
    • The classic presentation of SLE includes a butterfly pattern rash on the face, not lesions on the palms and soles, dry scaly patches, or cracked scaly areas.
    • Ankylosing spondylitis is characterized by inflammation, stiffness, and fusion of spinal joints.
    • Prosthetic joint infection is often due to bacterial spread to the joint via the bloodstream, not defective replacement material, joint injury, or arthritis.
    • Scleroderma involves fibrosis of connective tissue, not autoantibodies against acetylcholine receptors, infection by beta-hemolytic streptococcus, or inflammation caused by antigens.
    • The earliest manifestation of scleroderma is Raynaud phenomenon with blanching of the digits in response to cold.
    • The most common presenting sign/symptom with rheumatic fever is polyarthritis, not cardiac murmur or rash.

    Pathophysiology of Gout, Rheumatoid Arthritis, Ankylosing Spondylitis, and Osteoarthritis

    • The final chronic stage of gout is called tophaceous gout characterized by crystalline deposits in cartilage, synovial membranes, and soft tissue.
    • In rheumatoid arthritis, immune cells accumulate in pannus and destroy articular cartilage.
    • Gout occurs when uric acid crystals form in joints; calcium phosphate and beta-hydroxybutyric acid do not lead to crystal formation in gout.
    • Ankylosing spondylitis causes joint fibrosis, ossification, and fusion, most commonly of the intervertebral and sacroiliac joints.
    • The chief pathologic features of osteoarthritis are degeneration of articular cartilage, destruction of the bone under the cartilage, and thickening of the synovium.
    • Osteoarthritis involves a complex interaction between osteoclasts, osteoblasts, chondrocytes, and synoviocytes that eventually destroy cartilage and damage subchondral bone.
    • Characteristics of gout include disturbed uric acid metabolism, crystalline deposits in bony and connective tissue, and cardiac and renal involvement.
    • Manifestations of osteoarthritis include nodules on joints of the hands, crepitus with joint movement, and narrowing of joint spaces.
    • Signs/symptoms of Lyme disease include fever and chills, arthritic pain, headache, and myalgia, but not migratory rash.
    • Gouty arthritis and complicated gout are not the final stages of gout; asymptomatic hyperuricemia is the first stage of gout.
    • In ankylosing spondylitis, there is no costal cartilage degeneration, instability of synovial joints, or temporomandibular joint degeneration.
    • The pain in osteoarthritis is worse with activity and is relieved with rest; stiffness is relieved with joint use.

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    Description

    Test your knowledge of rheumatic diseases and their distinguishing characteristics with this informative quiz. From rheumatoid arthritis to systemic lupus erythematosus and ankylosing spondylitis, challenge yourself to identify the key features and symptoms of these conditions.

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