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Questions and Answers
What is the complication of gouty arthritis?
What is a clinical finding consistent with a diagnosis of rheumatoid arthritis?
What does the presence of rheumatoid factor autoantibodies indicate about rheumatoid arthritis?
What is the cause of gouty arthritis?
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What causes firm, crystallized nodules or 'tophi' at the affected joints?
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What is the clinical finding consistent with rheumatoid arthritis?
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What is not a causative factor in rheumatoid arthritis?
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What is the causative factor in gouty arthritis?
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What is the likely cause of rheumatoid arthritis?
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What is the cause of firm, crystallized nodules or 'tophi' at the affected joints?
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What is a clinical finding consistent with rheumatoid arthritis?
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What is not a causative factor in rheumatoid arthritis?
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What is the classic presentation of systemic lupus erythematosus (SLE)?
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What is the earliest manifestation of scleroderma?
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What is the most common presenting sign/symptom with rheumatic fever?
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What is ankylosing spondylitis characterized by?
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What does a positive antinuclear antibody test help confirm the diagnosis of?
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What is rheumatoid factor autoantibodies not indicative of?
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What is rheumatoid arthritis associated with?
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What does prosthetic joint infection often result from?
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What is systemic lupus erythematosus (SLE) attributed to?
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What should patients with SLE avoid to prevent the progression of cutaneous lesions?
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What does scleroderma involve?
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Which of the following is a characteristic of nonarticular rheumatism ('growing pain')?
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What causes rheumatoid arthritis?
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Which of the following is a systemic disorder?
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What are tophi in the context of gout?
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Which of the following is a characteristic of ankylosing spondylitis?
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What is the cause of scleroderma?
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What is the classic presentation of systemic lupus erythematosus (SLE)?
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What is the causative factor in gouty arthritis?
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What does adhesive capsulitis involve?
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What is the complication of gouty arthritis?
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What is not a systemic disease?
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What is the likely cause of rheumatoid arthritis?
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Which condition involves the accumulation of immune cells in pannus and destruction of articular cartilage?
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What is the final chronic stage of gout characterized by crystalline deposits in cartilage, synovial membranes, and soft tissue called?
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Which condition causes joint fibrosis, ossification, and fusion, most commonly of the intervertebral and sacroiliac joints?
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What are the chief pathologic features of osteoarthritis?
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What is a characteristic manifestation of osteoarthritis?
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What is the likely cause of gout?
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What is a characteristic of gout?
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What are the manifestations of ankylosing spondylitis?
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What is a characteristic finding in Lyme disease?
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What is the earliest stage of gout?
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What is the pain pattern in osteoarthritis?
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What is a characteristic feature of gouty arthritis?
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Study Notes
Rheumatic Diseases and Their Characteristics
- Rheumatoid factor autoantibodies do not indicate infection, infective process, or enzymatic defect.
- Rheumatoid arthritis is associated with systemic aching in the musculoskeletal system, debilitating joint pain and stiffness, and changes in daily activities.
- Systemic lupus erythematosus (SLE) is attributed to autoimmune mechanisms, not wear and tear on weight-bearing joints or septic joint inflammation.
- SLE leads to numerous complications due to immune injury to basement membranes.
- A positive antinuclear antibody test helps confirm the diagnosis of SLE.
- Patients with SLE should avoid sun exposure to prevent the progression of cutaneous lesions.
- The classic presentation of SLE includes a butterfly pattern rash on the face, not lesions on the palms and soles, dry scaly patches, or cracked scaly areas.
- Ankylosing spondylitis is characterized by inflammation, stiffness, and fusion of spinal joints.
- Prosthetic joint infection is often due to bacterial spread to the joint via the bloodstream, not defective replacement material, joint injury, or arthritis.
- Scleroderma involves fibrosis of connective tissue, not autoantibodies against acetylcholine receptors, infection by beta-hemolytic streptococcus, or inflammation caused by antigens.
- The earliest manifestation of scleroderma is Raynaud phenomenon with blanching of the digits in response to cold.
- The most common presenting sign/symptom with rheumatic fever is polyarthritis, not cardiac murmur or rash.
Pathophysiology of Gout, Rheumatoid Arthritis, Ankylosing Spondylitis, and Osteoarthritis
- The final chronic stage of gout is called tophaceous gout characterized by crystalline deposits in cartilage, synovial membranes, and soft tissue.
- In rheumatoid arthritis, immune cells accumulate in pannus and destroy articular cartilage.
- Gout occurs when uric acid crystals form in joints; calcium phosphate and beta-hydroxybutyric acid do not lead to crystal formation in gout.
- Ankylosing spondylitis causes joint fibrosis, ossification, and fusion, most commonly of the intervertebral and sacroiliac joints.
- The chief pathologic features of osteoarthritis are degeneration of articular cartilage, destruction of the bone under the cartilage, and thickening of the synovium.
- Osteoarthritis involves a complex interaction between osteoclasts, osteoblasts, chondrocytes, and synoviocytes that eventually destroy cartilage and damage subchondral bone.
- Characteristics of gout include disturbed uric acid metabolism, crystalline deposits in bony and connective tissue, and cardiac and renal involvement.
- Manifestations of osteoarthritis include nodules on joints of the hands, crepitus with joint movement, and narrowing of joint spaces.
- Signs/symptoms of Lyme disease include fever and chills, arthritic pain, headache, and myalgia, but not migratory rash.
- Gouty arthritis and complicated gout are not the final stages of gout; asymptomatic hyperuricemia is the first stage of gout.
- In ankylosing spondylitis, there is no costal cartilage degeneration, instability of synovial joints, or temporomandibular joint degeneration.
- The pain in osteoarthritis is worse with activity and is relieved with rest; stiffness is relieved with joint use.
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Description
Test your knowledge of rheumatic diseases and their distinguishing characteristics with this informative quiz. From rheumatoid arthritis to systemic lupus erythematosus and ankylosing spondylitis, challenge yourself to identify the key features and symptoms of these conditions.
