Rheumatoid Factor (RF) Quiz
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Questions and Answers

What is the role of the complement system in the immune system?

  • It produces antibodies against foreign substances.
  • It helps in blood clotting.
  • It regulates hormonal balance in the body.
  • It provides a defense mechanism against microbial invaders. (correct)

Why is ANA testing not suitable as a screening test for rheumatic or nonrheumatic diseases in asymptomatic individuals?

  • It is expensive.
  • It is time-consuming.
  • It requires specialized equipment.
  • It has low specificity. (correct)

Which diseases can result in hypocomplementemia due to the formation of immune complexes?

  • Diabetes and hypertension
  • SLE and RA (correct)
  • Osteoarthritis and gout
  • Influenza and common cold

Why should new complement test results be compared with previous test results rather than reference ranges?

<p>Reference ranges are relatively wide. (A)</p> Signup and view all the answers

What does the CH50 test measure?

<p>The ability of serum to lyse 50% of a standard suspension of sheep erythrocytes. (B)</p> Signup and view all the answers

Which complement protein appears to be more sensitive to small changes in complement activation?

<p>C4 (D)</p> Signup and view all the answers

What is the normal value for Rheumatoid factor (RF)?

<p>&lt; 1:20 or less than 20 international units / mL (C)</p> Signup and view all the answers

What does a titer of > 1:20 or a conc > 20 international units / mL generally indicate?

<p>A positive result for RF (D)</p> Signup and view all the answers

Which part of IgG do Rheumatoid factors (RFs) abnormally target?

<p>Fraction crystallizable (Fc) portion (A)</p> Signup and view all the answers

What is the most common disease associated with Rheumatoid factors (RFs)?

<p>Rheumatoid arthritis (RA) (B)</p> Signup and view all the answers

What is the significance of having both positive RF and positive anti-CCP antibody?

<p>99.5% specificity for RA (C)</p> Signup and view all the answers

What is the normal value for anti-CCP antibodies?

<p>&lt; 20 EU/mL (Eliza unite) (C)</p> Signup and view all the answers

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