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Rheumatoid Factor (RF) Quiz

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Questions and Answers

What is the role of the complement system in the immune system?

It produces antibodies against foreign substances.

It helps in blood clotting.

It regulates hormonal balance in the body.

It provides a defense mechanism against microbial invaders. (correct)

Why is ANA testing not suitable as a screening test for rheumatic or nonrheumatic diseases in asymptomatic individuals?

It is expensive.

It is time-consuming.

It requires specialized equipment.

It has low specificity. (correct)

Which diseases can result in hypocomplementemia due to the formation of immune complexes?

Diabetes and hypertension

SLE and RA (correct)

Osteoarthritis and gout

Influenza and common cold

Why should new complement test results be compared with previous test results rather than reference ranges?

Reference ranges are relatively wide. Signup and view all the answers

What does the CH50 test measure?

The ability of serum to lyse 50% of a standard suspension of sheep erythrocytes. Signup and view all the answers

Which complement protein appears to be more sensitive to small changes in complement activation?

C4 Signup and view all the answers

What is the normal value for Rheumatoid factor (RF)?

< 1:20 or less than 20 international units / mL Signup and view all the answers

What does a titer of > 1:20 or a conc > 20 international units / mL generally indicate?

A positive result for RF Signup and view all the answers

Which part of IgG do Rheumatoid factors (RFs) abnormally target?

Fraction crystallizable (Fc) portion Signup and view all the answers

What is the most common disease associated with Rheumatoid factors (RFs)?

Rheumatoid arthritis (RA) Signup and view all the answers

What is the significance of having both positive RF and positive anti-CCP antibody?

99.5% specificity for RA Signup and view all the answers

What is the normal value for anti-CCP antibodies?

< 20 EU/mL (Eliza unite) Signup and view all the answers