Rhabdoviridae

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Questions and Answers

The Family Rhabdoviridae has four subfamilies. What are these subfamilies?

Alpharhabdovirinae, betarhabdovirinae, Deltarhabdovirinae, and gammarhabdovirinae

Which of the following best describes the genome of rhabdoviruses?

  • Double-stranded, circular DNA
  • Single-stranded, linear, negative-sense RNA (correct)
  • Single-stranded, linear, positive-sense RNA
  • Double-stranded, segmented RNA

Which of the following disinfectants is NOT effective against rhabdoviruses?

  • Detergent-based disinfectants
  • Iodine-containing solutions
  • Oxidizing agents
  • Alcohol-based hand sanitizers (correct)

Which animals are known to be important reservoirs of rabies in North America?

<p>Bats, skunks, raccoons, foxes, and wolves (A)</p> Signup and view all the answers

In which of the following regions is urban rabies, with dogs as the main reservoir, the predominant cycle?

<p>Africa, Asia, Central and South America (C)</p> Signup and view all the answers

In many parts of the world bats e.g. _________________ are reservoirs of the rabies virus

<p>Silver-haired bats</p> Signup and view all the answers

In central and South America rabies is transmitted to cattle by vampire bats

<p>True (A)</p> Signup and view all the answers

What are the two epidemiological cycles the rabies virus infection is maintained?

<p>Urban and sylvatic cycles</p> Signup and view all the answers

Who is the main reservoir in the urban rabies cycle?

<p>Dogs (C)</p> Signup and view all the answers

What is the incubation period of rabies, respectively?

<p>14-90 days (even years)</p> Signup and view all the answers

Which of the following behavioral changes is commonly observed in the prodromal phase of rabies?

<p>Aggressiveness in normally tame animals (B)</p> Signup and view all the answers

Which of the following behavioral changes is is also observed in the prodromal phase of rabies?

<p>Daytime activities in nocturnal animals (A), No fear of humans in wild animals (C)</p> Signup and view all the answers

What is a characteristic sign of the excitative (fury) phase of rabies in dogs?

<p>High-pitched barking sound and severe agitation (B), Aggressiveness (D)</p> Signup and view all the answers

Why do rabid dogs exhibit foaming saliva around the mouth in the paralytic phase of rabies?

<p>The inability to swallow leads to excessive salivation (B)</p> Signup and view all the answers

Which of the following is the final outcome of the paralytic (dumb) phase in rabies-infected animals?

<p>Complete paralysis followed by death (C)</p> Signup and view all the answers

In the paralytic (dumb) phase, some animals may develop paralysis beginning at the hind extremities

<p>True (A)</p> Signup and view all the answers

How does the rabies virus first gain access to the nervous system?

<p>By binding to acetylcholine receptors at neuromuscular junctions (B)</p> Signup and view all the answers

What part of the central nervous system does the rabies virus infect to cause the "furious" stage of the disease?

<p>Limbic system (B)</p> Signup and view all the answers

Which of the following is a hallmark histopathological feature of rabies infection?

<p>Intracytoplasmic eosinophilic inclusion bodies (Negri bodies) in neurons (A)</p> Signup and view all the answers

Where should tissue samples be taken from to diagnose rabies post-mortem?

<p>Brainstem and cerebellum (B)</p> Signup and view all the answers

The diagnosis of rabies is performed only in reference laboratories

<p>True (A)</p> Signup and view all the answers

What is considered the gold standard for diagnosing rabies in laboratory settings?

<p>Fluorescent antibody test (FAT) (D)</p> Signup and view all the answers

Which of the following is necessary for the confirmation of a positive rabies diagnosis in a laboratory setting?

<p>Demonstration of rabies viral antigen, nucleic acid, or viable virus (C)</p> Signup and view all the answers

How is rabies virus typically isolated in the laboratory?

<p>Through cell culture inoculation (Rabies Tissue Culture Infection Test - RTCIT) (C)</p> Signup and view all the answers

Which of the following is the correct post-exposure prophylaxis recommendation for a human bitten by a healthy dog, cat, or ferret that is available for a 10-day observation period?

<p>No vaccination unless the animal develops clinical signs of rabies (B)</p> Signup and view all the answers

What is the recommended evaluation and disposition for raccoons, skunks, foxes, bats, and most other wild carnivores after a potential rabies exposure?

<p>Consider the animal rabid unless proven negative by laboratory testing (B)</p> Signup and view all the answers

Flashcards

Rhabdoviridae subfamilies

Alpharhabdovirinae, Betarhabdovirinae, Deltarhabdovirinae, and Gammarhabdovirinae.

Rhabdovirus genome

Single-stranded, linear, negative-sense RNA.

Ineffective disinfectant

Alcohol-based hand sanitizers

Rabies reservoirs (North America)

Bats, skunks, raccoons, foxes, and wolves

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Urban rabies regions

Africa, Asia, Central and South America

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Bat reservoir example

Silver-haired bats

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Vampire bats transmit rabies to cattle

True

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Rabies epidemiological cycles

Urban and Sylvatic cycles

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Main reservoir in urban rabies

Dogs

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Rabies incubation period

14-90 days (even years)

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Prodromal phase behavioral change

Aggressiveness in normally tame animals

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Prodromal phase behavioral change

Daytime activities in nocturnal animals

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Excitative rabies sign in dogs

High-pitched barking sound and severe agitation

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Foaming saliva in rabid dogs

The inability to swallow leads to excessive salivation

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Outcome of paralytic rabies

Transition back to the excitative phase

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