10 Questions
What is the purpose of taking a small piece of DNA from a virus or bacterium?
To produce a protein antigen for vaccination
What type of cells are commonly used as heterologous hosts for expressing immunogenic proteins?
Yeast cells, bacteria, insect cells, plant cells, and mammalian cell lines
What is the term for the part of an antigen molecule that an antibody attaches to?
Epitope
How does the yeast cell contribute to the production of the Hepatitis B surface antigen (HBsAg)?
It performs post-translational modifications, including glycosylation
What is the form in which the HBsAg assembles after expression in yeast cells?
Virus-like particles (VLPs)
What is the advantage of producing HBsAg in yeast cells?
All of the above
What is the term for the process of using a part of the pathogen's DNA to produce a vaccine?
Recombinant protein vaccine production
What is the purpose of transforming the recombinant plasmids into yeast cells?
To produce the desired antigen
What is the benefit of using yeast cells for the production of HBsAg?
They allow for high expression levels and easy purification
What is the term for the study of the epitopes of a pathogen to identify potential vaccine targets?
Reverse vaccinology
Learn how reverse vaccinology is used to identify vaccine candidates through the use of computer algorithms, protein cloning, and immunogenicity screening. Discover the advantages of this approach in vaccine development.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
