Reverse Vaccinology: Identifying Vaccine Candidates
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Questions and Answers

What is the purpose of taking a small piece of DNA from a virus or bacterium?

  • To study the pathogen's genetic sequence
  • To create a toxin that fights the pathogen
  • To produce a protein antigen for vaccination (correct)
  • To create a clone of the pathogen

What type of cells are commonly used as heterologous hosts for expressing immunogenic proteins?

  • Yeast cells, bacteria, insect cells, plant cells, and mammalian cell lines (correct)
  • Plant cells and mammalian cell lines
  • Fungal cells and mammalian cells
  • Bacterial cells and insect cells

What is the term for the part of an antigen molecule that an antibody attaches to?

  • Vaccine
  • Epitope (correct)
  • Antigen
  • Immunogen

How does the yeast cell contribute to the production of the Hepatitis B surface antigen (HBsAg)?

<p>It performs post-translational modifications, including glycosylation (B)</p> Signup and view all the answers

What is the form in which the HBsAg assembles after expression in yeast cells?

<p>Virus-like particles (VLPs) (D)</p> Signup and view all the answers

What is the advantage of producing HBsAg in yeast cells?

<p>All of the above (D)</p> Signup and view all the answers

What is the term for the process of using a part of the pathogen's DNA to produce a vaccine?

<p>Recombinant protein vaccine production (D)</p> Signup and view all the answers

What is the purpose of transforming the recombinant plasmids into yeast cells?

<p>To produce the desired antigen (B)</p> Signup and view all the answers

What is the benefit of using yeast cells for the production of HBsAg?

<p>They allow for high expression levels and easy purification (A)</p> Signup and view all the answers

What is the term for the study of the epitopes of a pathogen to identify potential vaccine targets?

<p>Reverse vaccinology (D)</p> Signup and view all the answers

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