18 Questions
What is a benefit of using synthetic peptides in vaccine development?
They eliminate the possibility of reversion to virulence.
What is the main advantage of edible vaccines?
They offer a cost-effective way of delivering vaccines.
What is the principle behind naked DNA vaccines?
The injection of plasmids carrying the gene for the protein of interest into host cells.
What is the advantage of using recombinant DNA techniques in vaccine development?
They allow for the production of vaccines that are cheaper than traditional methods.
What is a challenge of using synthetic peptides in vaccine development?
The immune response induced is considerably weaker than that induced by intact proteins.
What is a goal of the approaches mentioned in the text?
To improve vaccine safety by avoiding the incorporation of viral nucleic acid.
What is the genetic basis of the attenuation of most viral vaccines?
The genetic basis is not known because it was selected empirically.
What is a characteristic of killed-virus vaccines prepared from whole virions?
They stimulate the development of circulating antibody against the coat proteins of the virus.
What is a difference between killed-virus vaccines and live-virus vaccines?
Killed-virus vaccines use virus mutants that antigenically overlap with wild-type virus.
What is a disadvantage of killed-virus vaccines?
They do not provide lifelong immunity to the virus strain.
What is the purpose of mild formalin treatment in vaccine development?
To kill the virus and render it non-infectious.
What is the advantage of live-virus vaccines compared to killed-virus vaccines?
They act more like a natural infection with regard to their effect on immunity.
What is the primary mechanism of action of enfuvirtide in treating viral infections?
It blocks the conformational change that initiates membrane fusion
What is the advantage of valacyclovir over acyclovir?
It can be taken orally and is metabolized to acyclovir
What is the primary target of ganciclovir in treating CMV infections?
DNA polymerase
What is the primary role of the immune response in preventing viral disease?
To recognize and respond to specific antigens on the surface of virus particles
What is a characteristic of enveloped viruses that is important for vaccine development?
The presence of surface glycoproteins
What is the primary goal of viral vaccine development?
To use the adaptive immune response of the host to prevent viral disease
Explore the latest approaches in vaccine development, including the use of synthetic peptides to avoid viral nucleic acid and improve safety. Learn about the ongoing efforts in this field and their potential success.
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